2024-01-17
definition
IAO:0000233
external
term_tracker_item
true
true
term_tracker_item
term tracker item
IAO:0000700
external
has_ontology_root_term
true
true
has_ontology_root_term
has ontology root term
term replaced by
Rhea list of ChEBI terms representing the major species at pH 7.3.
Term not to be used for direct annotation
Term not to be used for direct manual annotation
AGR slim
Aspergillus GO slim
Candida GO slim
ChEMBL protein targets summary
Drosophila GO slim
FlyBase Drosophila GO ribbon slim
Generic GO slim
Metagenomics GO slim
Mouse GO slim
PIR GO slim
Plant GO slim
Fission yeast GO slim
GO subset for prokaryotes
synapse GO slim
Yeast GO slim
label approved by the SynGO project
Systematic synonym
subset_property
synonym_type_property
consider
has_alternative_id
has_broad_synonym
database_cross_reference
has_exact_synonym
has_narrow_synonym
has_obo_format_version
has_obo_namespace
has_related_synonym
has_scope
has_synonym_type
in_subset
shorthand
BFO:0000050
external
part_of
part_of
part of
BFO:0000051
external
has_part
has_part
has part
BFO:0000066
external
occurs_in
occurs_in
occurs in
RO:0002091
external
starts_during
starts_during
starts during
RO:0002092
external
happens_during
happens_during
happens during
RO:0002093
external
ends_during
ends_during
ends during
RO:0002211
external
regulates
regulates
regulates
RO:0002212
external
negatively_regulates
negatively_regulates
negatively regulates
RO:0002213
external
positively_regulates
positively_regulates
positively regulates
The directed movement of neurotransmitters into neurons or glial cells. This process leads to inactivation and recycling of neurotransmitters.
neurotransmitter recycling
neurotransmitter import
neurotransmitter import into glial cell
neurotransmitter import into neuron
biological_process
GO:0001504
neurotransmitter uptake
The directed movement of neurotransmitters into neurons or glial cells. This process leads to inactivation and recycling of neurotransmitters.
ISBN:0123668387
neurotransmitter import
GOC:dph
GOC:tb
The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
signal transmission across a synapse
synaptic transmission
Wikipedia:Neurotransmission
biological_process
neurotransmission
GO:0007268
chemical synaptic transmission
The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
GOC:jl
MeSH:D009435
neurotransmission
GOC:dph
The regulated release of neurotransmitter from the presynapse into the synaptic cleft via calcium-regulated exocytosis during synaptic transmission.
GO:0010554
neurotransmitter release
neurotransmitter secretory pathway
biological_process
GO:0007269
A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma-aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin.
neurotransmitter secretion
The regulated release of neurotransmitter from the presynapse into the synaptic cleft via calcium-regulated exocytosis during synaptic transmission.
GOC:dph
The aggregation, arrangement and bonding together of a set of components to form a synapse. This process ends when the synapse is mature (functional).
Wikipedia:Synaptogenesis
synapse biogenesis
synaptogenesis
biological_process
GO:0007416
synapse assembly
The aggregation, arrangement and bonding together of a set of components to form a synapse. This process ends when the synapse is mature (functional).
GOC:mah
synapse biogenesis
GOC:mah
synaptogenesis
GOC:mah
A secretory organelle, typically 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane.
NIF_Subcellular:sao1071221672
Wikipedia:Synaptic_vesicle
docked vesicle
cellular_component
GO:0008021
This term should not be confused with GO:0097547 'synaptic vesicle protein transport vesicle'. STVs and synaptic vesicles differ both functionally and morphologically. Functionally, STVs are transport vesicles that deliver synaptic vesicle proteins to synapses, while synaptic vesicles are responsible for transmitter release at synapses. Morphologically, synaptic vesicles are very homogeneous, while STVs are very heterogeneous in size and shape. STVs might be a precursor for synaptic vesicles.
synaptic vesicle
A secretory organelle, typically 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane.
PMID:10099709
PMID:12563290
docked vesicle
NIF_Subcellular:sao403156667
The process in which a neuronal cell in a multicellular organism interprets signals produced by potential target cells, with which it may form synapses.
neuronal targeting
biological_process
GO:0008039
synaptic target recognition
The process in which a neuronal cell in a multicellular organism interprets signals produced by potential target cells, with which it may form synapses.
GOC:mah
ISBN:0878932437
The directed movement of organelles or molecules along microtubules in neuron projections.
Wikipedia:Axoplasmic_transport
axon cargo transport
axonal transport
axoplasmic transport
biological_process
GO:0008088
axo-dendritic transport
The directed movement of organelles or molecules along microtubules in neuron projections.
ISBN:0815316194
The directed movement of organelles or molecules along microtubules from the cell body toward the cell periphery in nerve cell axons.
anterograde axon cargo transport
biological_process
GO:0008089
anterograde axonal transport
The directed movement of organelles or molecules along microtubules from the cell body toward the cell periphery in nerve cell axons.
ISBN:0815316194
The directed movement of organelles or molecules along microtubules from the cell periphery toward the cell body in nerve cell axons.
retrograde axon cargo transport
biological_process
GO:0008090
retrograde axonal transport
The directed movement of organelles or molecules along microtubules from the cell periphery toward the cell body in nerve cell axons.
ISBN:0815316194
Any process that modulates the frequency, rate or extent of synaptic vesicle priming. Synaptic vesicle priming is the formation of SNARE-containing complexes, bringing synaptic vesicle membrane and plasma membranes into close proximity and thereby facilitating membrane fusion.
biological_process
GO:0010807
regulation of synaptic vesicle priming
Any process that modulates the frequency, rate or extent of synaptic vesicle priming. Synaptic vesicle priming is the formation of SNARE-containing complexes, bringing synaptic vesicle membrane and plasma membranes into close proximity and thereby facilitating membrane fusion.
GOC:dph
GOC:kmv
GOC:tb
PMID:15489511
An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components.
pr
2013-07-02T09:44:28Z
GO:0097481
GO:0097483
NIF_Subcellular:sao1196688972
Wikipedia:Postsynaptic_density
neuronal postsynaptic density
post synaptic density
post-synaptic density
postsynaptic density of dendrite
cellular_component
GO:0014069
postsynaptic density
An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components.
GOC:BHF
GOC:dos
GOC:ef
GOC:jid
GOC:pr
GOC:sjp
PMID:14532281
Wikipedia:Postsynaptic_density
http://molneuro.kaist.ac.kr/psd
neuronal postsynaptic density
GO:0097481
Fusion of intracellular membrane-bounded vesicles with the pre-synaptic membrane of the neuronal cell resulting in release of neurotransmitter into the synaptic cleft.
biological_process
GO:0016079
synaptic vesicle exocytosis
Fusion of intracellular membrane-bounded vesicles with the pre-synaptic membrane of the neuronal cell resulting in release of neurotransmitter into the synaptic cleft.
GOC:jid
GOC:lmg
The initial (indirect) attachment of a synaptic vesicle membrane to the presynaptic active zone membrane, mediated by proteins protruding from the membrane and proteins of the presynaptic active zone cytoplasmic component. Synaptic vesicle tethering is the first step in this process.
synaptic vesicle docking involved in exocytosis
biological_process
synaptic vesicle docking during exocytosis
GO:0016081
Although this process can occur outside of synaptic transmission, by convention we treat it as a part of synaptic transmission (dos, pvn, fk synapse project 2015).
synaptic vesicle docking
The initial (indirect) attachment of a synaptic vesicle membrane to the presynaptic active zone membrane, mediated by proteins protruding from the membrane and proteins of the presynaptic active zone cytoplasmic component. Synaptic vesicle tethering is the first step in this process.
PMID:15217342
synaptic vesicle docking during exocytosis
GOC:dph
GOC:tb
A process that converts synaptic vesicles to a state of competence for calcium triggered fusion with the active zone membrane by bringing the two membranes into very close proximity. Priming typically (but not always) occurs after docking (Jahn and Fasshauer, 2012). Primed vesicles are also capable of spontaneously fusing with the active zone membrane.
biological_process
GO:0016082
Although this process can occur outside of synaptic transmission, by convention we treat it as a part of synaptic transmission. (dos, pvn, fk synapse project 2015)
synaptic vesicle priming
A process that converts synaptic vesicles to a state of competence for calcium triggered fusion with the active zone membrane by bringing the two membranes into very close proximity. Priming typically (but not always) occurs after docking (Jahn and Fasshauer, 2012). Primed vesicles are also capable of spontaneously fusing with the active zone membrane.
GOC:mah
PMID:15217342
PMID:23060190
Budding of synaptic vesicles during the formation of constitutive recycling vesicles from early endosomes.
synaptic vesicle budding involved in synaptic vesicle exocytosis
biological_process
endosome to synaptic vesicle budding
GO:0016182
synaptic vesicle budding from endosome
Budding of synaptic vesicles during the formation of constitutive recycling vesicles from early endosomes.
GOC:curators
PMID:10099709
PMID:24596248
synaptic vesicle budding involved in synaptic vesicle exocytosis
GOC:mah
endosome to synaptic vesicle budding
GOC:mah
The formation of clathrin coated pits in the presynaptic membrane endocytic zone, triggered by the presence of high concentrations of synaptic vesicle components. This process leads to, but does not include budding of the membrane to form new vesicles.
biological_process
GO:0016183
synaptic vesicle coating
The formation of clathrin coated pits in the presynaptic membrane endocytic zone, triggered by the presence of high concentrations of synaptic vesicle components. This process leads to, but does not include budding of the membrane to form new vesicles.
GOC:curators
PMID:10099709
PMID:20448150
Evagination of the presynaptic membrane, resulting in the formation of a new synaptic vesicle.
synaptic vesicle budding from pre-synaptic membrane
synaptic vesicle budding involved in synaptic vesicle endocytosis
biological_process
GO:0016185
synaptic vesicle budding from presynaptic endocytic zone membrane
Evagination of the presynaptic membrane, resulting in the formation of a new synaptic vesicle.
GOC:curators
PMID:10099709
PMID:20448150
synaptic vesicle budding involved in synaptic vesicle endocytosis
GOC:mah
Fusion of a synaptic vesicle with an endosome.
biological_process
GO:0016189
This covers fusion of synaptic vesicles trafficked to the synapse as well as fusion of endocytosed vesicles as part of recycling. It is there for not part of the synaptic vesicle cycle.
synaptic vesicle to endosome fusion
Fusion of a synaptic vesicle with an endosome.
GOC:curators
PMID:10099709
The removal of the protein coat on a synaptic vesicle following the pinching step at the end of budding from the presynaptic membrane.
synaptic vesicle coat depolymerization
synaptic vesicle coat protein depolymerization
biological_process
GO:0016191
synaptic vesicle uncoating
The removal of the protein coat on a synaptic vesicle following the pinching step at the end of budding from the presynaptic membrane.
GOC:curators
PMID:10099709
PMID:24596248
The directed movement of mitochondria along microtubules in nerve cell axons.
axon transport of mitochondria
biological_process
GO:0019896
axonal transport of mitochondrion
The directed movement of mitochondria along microtubules in nerve cell axons.
GOC:ai
The lipid bilayer surrounding a synaptic vesicle.
cellular_component
GO:0030672
synaptic vesicle membrane
The lipid bilayer surrounding a synaptic vesicle.
GOC:mah
Fusion of the membrane of a synaptic vesicle with the presynaptic active zone membrane, thereby releasing its cargo neurotransmitters into the synaptic cleft.
synaptic vesicle fusion
synaptic vesicle fusion to pre-synaptic membrane
synaptic vesicle fusion to presynaptic membrane
biological_process
GO:0031629
synaptic vesicle fusion to presynaptic active zone membrane
Fusion of the membrane of a synaptic vesicle with the presynaptic active zone membrane, thereby releasing its cargo neurotransmitters into the synaptic cleft.
GOC:aruk
GOC:bc
ISBN:0071120009
PMID:18618940
Any process that modulates the frequency, rate or extent of synaptic vesicle fusion to the presynaptic membrane.
regulation of synaptic vesicle fusion to pre-synaptic membrane
regulation of synaptic vesicle fusion to presynaptic membrane
biological_process
GO:0031630
regulation of synaptic vesicle fusion to presynaptic active zone membrane
Any process that modulates the frequency, rate or extent of synaptic vesicle fusion to the presynaptic membrane.
GOC:mah
The volume enclosed by the synaptic vesicle membrane.
cellular_component
GO:0034592
synaptic vesicle lumen
The volume enclosed by the synaptic vesicle membrane.
GOC:rph
Synaptic vesicle recycling where vesicles endocytosed via clathrin-coated pits re-acidify and refill with neurotransmitters after passing through an endosomal intermediate.
bf
2014-06-26T11:07:46Z
GO:0099090
recycling endosome localization within postsynapse
biological_process
GO:0036466
synaptic vesicle recycling via endosome
Synaptic vesicle recycling where vesicles endocytosed via clathrin-coated pits re-acidify and refill with neurotransmitters after passing through an endosomal intermediate.
GOC:PARL
GOC:aruk
GOC:bc
GOC:bf
GOC:dos
GOC:pad
PMID:15217342
A specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction; many synaptic junctions exhibit structural presynaptic characteristics, such as conical, electron-dense internal protrusions, that distinguish it from the remainder of the axon plasma membrane.
pre-synaptic membrane
presynaptic plasma membrane
cellular_component
GO:0042734
presynaptic membrane
A specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction; many synaptic junctions exhibit structural presynaptic characteristics, such as conical, electron-dense internal protrusions, that distinguish it from the remainder of the axon plasma membrane.
GOC:jl
ISBN:0815316194
The narrow gap that separates the presynaptic and postsynaptic membranes, into which neurotransmitter is released.
NIF_Subcellular:sao243541954
cellular_component
GO:0043083
synaptic cleft
The narrow gap that separates the presynaptic and postsynaptic membranes, into which neurotransmitter is released.
GOC:jl
http://synapses.mcg.edu/anatomy/chemical/synapse.stm
A small, membranous protrusion from a dendrite that forms a postsynaptic compartment, typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable:they can be thin, stubby, mushroom, or branched, with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity.
NIF_Subcellular:sao1799103720
Wikipedia:Dendritic_spine
dendrite spine
branched dendritic spine
mushroom dendritic spine
sessile dendritic spine
stubby dendritic spine
thin dendritic spine
cellular_component
GO:0043197
dendritic spine
A small, membranous protrusion from a dendrite that forms a postsynaptic compartment, typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable:they can be thin, stubby, mushroom, or branched, with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity.
GOC:nln
branched dendritic spine
NIF_Subcellular:sao965204139
mushroom dendritic spine
NIF_Subcellular:sao876577163
sessile dendritic spine
NIF_Subcellular:sao1536532595
stubby dendritic spine
NIF_Subcellular:sao317384566
thin dendritic spine
NIF_Subcellular:sao1232858786
The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.
NIF_Subcellular:sao914572699
Wikipedia:Chemical_synapse
synaptic junction
mixed synapse
cellular_component
electrotonic synapse
GO:0045202
synapse
The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.
GOC:aruk
ISBN:0198506732
PMID:24619342
PMID:29383328
PMID:31998110
mixed synapse
NIF_Subcellular:sao1506103497
electrotonic synapse
NIF_Subcellular:sao1311109124
A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane.
post-synaptic membrane
cellular_component
GO:0045211
postsynaptic membrane
A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane.
ISBN:0198506732
A vesicle-mediated transport process, in which the synaptic vesicle membrane constituents are retrieved from the presynaptic membrane on the axon terminal after neurotransmitter secretion by exocytosis. Synaptic vesicle endocytosis can occur via clathrin-dependent and clathrin-independent mechanisms.
https://github.com/geneontology/synapse/issues/230
GO:0008099
biological_process
synaptic vesicle retrieval
GO:0048488
synaptic vesicle endocytosis
A vesicle-mediated transport process, in which the synaptic vesicle membrane constituents are retrieved from the presynaptic membrane on the axon terminal after neurotransmitter secretion by exocytosis. Synaptic vesicle endocytosis can occur via clathrin-dependent and clathrin-independent mechanisms.
GOC:aruk
GOC:bc
GOC:jid
GOC:lmg
GOC:mah
PMID:20448150
PMID:26430111
The directed movement of synaptic vesicles.
GO:0016181
biological_process
synaptic vesicle fission
synaptic vesicle fusion
synaptic vesicle trafficking
GO:0048489
synaptic vesicle transport
The directed movement of synaptic vesicles.
GOC:aruk
GOC:bc
GOC:jid
GOC:lmg
GOC:pr
synaptic vesicle trafficking
PMID:15217342
The directed movement of synaptic vesicle along axonal microtubules from the cell body to the presynapse.
anterograde axonal transport of synaptic vesicle
biological_process
GO:0048490
anterograde synaptic vesicle transport
The directed movement of synaptic vesicle along axonal microtubules from the cell body to the presynapse.
GOC:jid
GOC:lmg
The directed movement of synaptic vesicle along axonal microtubules from the presynapse to the cell body.
retrograde axonal transport of synaptic vesicle
biological_process
GO:0048491
retrograde synaptic vesicle transport
The directed movement of synaptic vesicle along axonal microtubules from the presynapse to the cell body.
GOC:jid
GOC:lmg
PMID:24762653
A specialized region of the plasma membrane and cell cortex of a presynaptic neuron; encompasses a region of the plasma membrane where synaptic vesicles dock and fuse, and a specialized cortical cytoskeletal matrix.
NIF_Subcellular:sao792027222
pre-synaptic active zone
presynaptic specialization
pre-synaptic active zone component
cellular_component
GO:0048786
presynaptic active zone
A specialized region of the plasma membrane and cell cortex of a presynaptic neuron; encompasses a region of the plasma membrane where synaptic vesicles dock and fuse, and a specialized cortical cytoskeletal matrix.
GOC:dh
GOC:dl
GOC:ef
GOC:jid
GOC:pr
PMID:3152289
pre-synaptic active zone component
NIF_Subcellular:sao1911631652
The membrane portion of the presynaptic active zone; it is the site where docking and fusion of synaptic vesicles occurs for the release of neurotransmitters.
NIF_Subcellular:sao2038461087
active zone plasma membrane
active zone pre-synaptic plasma membrane
active zone presynaptic plasma membrane
pre-synaptic active zone membrane
cellular_component
GO:0048787
presynaptic active zone membrane
The membrane portion of the presynaptic active zone; it is the site where docking and fusion of synaptic vesicles occurs for the release of neurotransmitters.
PMID:12812759
PMID:12923177
PMID:3152289
active zone plasma membrane
NIF_Subcellular:sao2038461087
A process which maintains the organization and the arrangement of proteins at the active zone to ensure the fusion and docking of vesicles and the release of neurotransmitters.
maintenance of pre-synaptic active zone structure
biological_process
GO:0048790
maintenance of presynaptic active zone structure
A process which maintains the organization and the arrangement of proteins at the active zone to ensure the fusion and docking of vesicles and the release of neurotransmitters.
GOC:curators
GOC:dph
GOC:pr
Any process that modulates the frequency or amplitude of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. Amplitude, in this case, refers to the change in postsynaptic membrane potential due to a single instance of synaptic transmission.
modulation of synaptic transmission
regulation of chemical synaptic transmission
regulation of synaptic transmission
biological_process
GO:0050804
modulation of chemical synaptic transmission
Any process that modulates the frequency or amplitude of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. Amplitude, in this case, refers to the change in postsynaptic membrane potential due to a single instance of synaptic transmission.
GOC:ai
Any process that modulates the physical form of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell).
regulation of synapse organisation
regulation of synapse structure
biological_process
regulation of synapse organization and biogenesis
GO:0050807
regulation of synapse organization
Any process that modulates the physical form of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell).
GOC:ai
GOC:dph
GOC:tb
regulation of synapse organisation
GOC:mah
regulation of synapse organization and biogenesis
GOC:mah
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell).
synapse organisation
biological_process
synapse development
synapse morphogenesis
synapse organization and biogenesis
GO:0050808
synapse organization
synapse organization and biogenesis
GOC:mah
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell).
GOC:ai
GOC:pr
synapse development
GOC:aruk
synapse morphogenesis
GOC:BHF
Any process that modulates the frequency, rate or extent of the directed movement of a neurotransmitter into a neuron or glial cell.
regulation of neurotransmitter import
regulation of neurotransmitter reuptake
biological_process
GO:0051580
regulation of neurotransmitter uptake
Any process that modulates the frequency, rate or extent of the directed movement of a neurotransmitter into a neuron or glial cell.
GOC:ai
regulation of neurotransmitter import
GOC:dph
GOC:tb
Any process that modulates the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse.
regulation of synapse biogenesis
regulation of synaptogenesis
biological_process
GO:0051963
regulation of synapse assembly
Any process that modulates the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse.
GOC:ai
GOC:pr
The process that organizes a synapse so that it attains its fully functional state. Synaptic maturation plays a critical role in the establishment of effective synaptic connections in early development.
synaptic maturation
biological_process
GO:0060074
synapse maturation
The process that organizes a synapse so that it attains its fully functional state. Synaptic maturation plays a critical role in the establishment of effective synaptic connections in early development.
GOC:dph
GOC:ef
Any process that modulates the potential difference across a post-synaptic membrane.
regulation of post-synaptic membrane potential
biological_process
GO:0060078
regulation of postsynaptic membrane potential
Any process that modulates the potential difference across a post-synaptic membrane.
GOC:dph
GOC:ef
Any process that modulates the extent of synapse maturation, the process that organizes a synapse so that it attains its fully functional state.
tb
2009-12-07T03:00:58Z
biological_process
GO:0090128
regulation of synapse maturation
Any process that modulates the extent of synapse maturation, the process that organizes a synapse so that it attains its fully functional state.
GOC:ascb_2009
GOC:dph
GOC:tb
A specialized area of membrane on either the presynaptic or the postsynaptic side of a synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell.
pr
2011-06-07T11:22:09Z
cellular_component
GO:0097060
synaptic membrane
A specialized area of membrane on either the presynaptic or the postsynaptic side of a synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell.
GOC:BHF
PMID:20410104
The process that results in grouping synaptic vesicles in presynaptic structures.
https://github.com/geneontology/synapse/issues/163
pr
2011-07-04T01:48:24Z
biological_process
GO:0097091
synaptic vesicle clustering
The process that results in grouping synaptic vesicles in presynaptic structures.
GOC:ans
GOC:pr
PMID:19900895
PMID:7568108
The aggregation, arrangement and bonding together of a set of components to form a postsynaptic membrane, a specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft).
pr
2011-07-27T01:26:49Z
post-synaptic membrane assembly
biological_process
GO:0097104
postsynaptic membrane assembly
The aggregation, arrangement and bonding together of a set of components to form a postsynaptic membrane, a specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft).
GOC:BHF
GOC:sjp
PMID:21424692
The aggregation, arrangement and bonding together of a set of components to form a presynaptic membrane, including any proteins associated with the membrane, but excluding other cellular components. A presynaptic membrane is a specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction.
pr
2011-07-27T01:30:45Z
pre-synaptic membrane assembly
biological_process
GO:0097105
Note that 'presynaptic membrane' in this term should not be mistaken with 'presynaptic active zone'. The latter encompasses more than the former, as it also includes the specialized cortical cytoskeletal matrix in the cell cortex of a presynaptic neuron.
presynaptic membrane assembly
The aggregation, arrangement and bonding together of a set of components to form a presynaptic membrane, including any proteins associated with the membrane, but excluding other cellular components. A presynaptic membrane is a specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction.
GOC:BHF
GOC:pr
GOC:sjp
PMID:15797875
PMID:18550748
The aggregation, arrangement and bonding together of a set of components to form a postsynaptic density, a region that lies adjacent to the cytoplasmic face of the postsynaptic membrane at excitatory synapse.
pr
2011-07-27T05:21:39Z
PSD assembly
post synaptic density assembly
post-synaptic density assembly
biological_process
GO:0097107
postsynaptic density assembly
The aggregation, arrangement and bonding together of a set of components to form a postsynaptic density, a region that lies adjacent to the cytoplasmic face of the postsynaptic membrane at excitatory synapse.
GOC:BHF
GOC:sjp
PMID:21525273
The acidification of the synaptic vesicle lumen via transport of protons into the vesicle. The resulting electrochemical gradient powers neurotransmitter loading.
pr
2012-10-25T09:03:34Z
synaptic vesicle lumen pH reduction
synaptic vesicle proton loading
biological_process
GO:0097401
synaptic vesicle lumen acidification
The acidification of the synaptic vesicle lumen via transport of protons into the vesicle. The resulting electrochemical gradient powers neurotransmitter loading.
GOC:dsf
PMID:21172605
PMID:22875945
synaptic vesicle proton loading
A specialization of the endomembrane system found in some classes of dendritic spines consisting of two or more closely apposed lamellae with interspersed electron dense material. The endomembrane component is continuous with the smooth endoplasmic reticulum.
pr
2012-12-06T14:05:58Z
NIF_Subcellular:sao725931194
dense material
cellular_component
GO:0097444
spine apparatus
A specialization of the endomembrane system found in some classes of dendritic spines consisting of two or more closely apposed lamellae with interspersed electron dense material. The endomembrane component is continuous with the smooth endoplasmic reticulum.
NIF_Subcellular:sao725931194
PMID:20400711
PMID:8987748
dense material
NIF_Subcellular:sao1004601938
A synapse of a mossy fiber onto the dendrite of a granule cell; each mossy fiber can have up to 50 rosettes.
pr
2013-02-21T07:42:52Z
NIF_Subcellular:nlx_subcell_091021
cerebellar mossy fiber to granule cell synapse
cellular_component
GO:0097471
mossy fiber rosette
A synapse of a mossy fiber onto the dendrite of a granule cell; each mossy fiber can have up to 50 rosettes.
NIF_Subcellular:nlx_subcell_091021
Wikipedia:Mossy_fiber_(cerebellum)
cerebellar mossy fiber to granule cell synapse
The component of the neuronal dense core vesicle membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
dos
2017-01-17T16:20:56Z
cellular_component
GO:0098674
extrinsic component of neuronal dense core vesicle membrane
The component of the neuronal dense core vesicle membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
GOC:dos
A ribbon synpase of an auditory hair cell of the cochlear. These ribbon synapses contain spherical synaptic ribbons and lack and arciform density.
dos
2017-02-05T16:16:49Z
cellular_component
GO:0098683
cochlear hair cell ribbon synapse
A ribbon synpase of an auditory hair cell of the cochlear. These ribbon synapses contain spherical synaptic ribbons and lack and arciform density.
PMID:15626493
A ribbon synapse between a retinal photoreceptor cell (rod or cone) and a retinal bipolar cell. These contain a plate-like synaptic ribbon.
dos
2017-02-05T16:26:27Z
cellular_component
GO:0098684
photoreceptor ribbon synapse
A ribbon synapse between a retinal photoreceptor cell (rod or cone) and a retinal bipolar cell. These contain a plate-like synaptic ribbon.
PMID:15626493
A synapse between the Schaffer collateral axon of a CA3 pyramidal cell and a CA1 pyramidal cell.
dos
2017-02-05T16:29:43Z
cellular_component
GO:0098685
Schaffer collateral - CA1 synapse
A synapse between the Schaffer collateral axon of a CA3 pyramidal cell and a CA1 pyramidal cell.
PMID:16399689
One of the giant synapses that form between the mossy fiber axons of dentate gyrus granule cells and the large complex spines of CA3 pyramidal cells. It consists of a giant bouton known as the mossy fiber expansion, synapsed to the complex, multiheaded spine (thorny excresence) of a CA3 pyramidal cell.
dos
2017-02-05T16:29:58Z
cellular_component
GO:0098686
hippocampal mossy fiber to CA3 synapse
One of the giant synapses that form between the mossy fiber axons of dentate gyrus granule cells and the large complex spines of CA3 pyramidal cells. It consists of a giant bouton known as the mossy fiber expansion, synapsed to the complex, multiheaded spine (thorny excresence) of a CA3 pyramidal cell.
DOI:10.1002/1096-9861
PMID:13869693
PMID:23264762
An excitatory synapse formed by the parallel fibers of granule cells synapsing onto the dendrites of Purkinje cells.
dos
2017-02-21T18:32:05Z
cellular_component
GO:0098688
parallel fiber to Purkinje cell synapse
An excitatory synapse formed by the parallel fibers of granule cells synapsing onto the dendrites of Purkinje cells.
PMID:16623829
PMID:3209740
A synapse that uses glycine as a neurotransmitter.
dos
2017-03-07T14:50:33Z
cellular_component
GO:0098690
glycinergic synapse
A synapse that uses glycine as a neurotransmitter.
GOC:dos
A synapse that uses dopamine as a neurotransmitter.
dos
2017-03-07T14:51:52Z
cellular_component
GO:0098691
dopaminergic synapse
A synapse that uses dopamine as a neurotransmitter.
GOC:dos
Any process that modulates the frequency, rate or extent of the synaptic vesicle cycle.
dos
2017-03-21T16:06:48Z
biological_process
GO:0098693
regulation of synaptic vesicle cycle
Any process that modulates the frequency, rate or extent of the synaptic vesicle cycle.
GOC:dos
Any process that modulates the frequency, rate or extent of synaptic vesicle budding from presynaptic endocytic zone membrane.
dos
2017-04-04T17:03:29Z
biological_process
GO:0098694
regulation of synaptic vesicle budding from presynaptic endocytic zone membrane
Any process that modulates the frequency, rate or extent of synaptic vesicle budding from presynaptic endocytic zone membrane.
GOC:dos
Any inositol 1,4,5-trisphosphate receptor activity that is involved in regulation of postsynaptic cytosolic calcium ion concentration.
dos
2017-04-04T17:07:09Z
IP3 receptor activity involved in regulation of postsynaptic cytosolic calcium levels
molecular_function
GO:0098695
inositol 1,4,5-trisphosphate receptor activity involved in regulation of postsynaptic cytosolic calcium levels
Any inositol 1,4,5-trisphosphate receptor activity that is involved in regulation of postsynaptic cytosolic calcium ion concentration.
GOC:dos
Any process that modulates the frequency, rate or extent of neurotransmitter receptor localization to postsynaptic specialization membrane.
dos
2017-04-04T16:33:38Z
biological_process
GO:0098696
regulation of neurotransmitter receptor localization to postsynaptic specialization membrane
Any process that modulates the frequency, rate or extent of neurotransmitter receptor localization to postsynaptic specialization membrane.
GOC:dos
Any ryanodine-sensitive calcium-release channel activity that is involved in regulation of postsynaptic cytosolic calcium ion concentration.
dos
2017-04-04T17:11:38Z
molecular_function
GO:0098697
ryanodine-sensitive calcium-release channel activity involved in regulation of postsynaptic cytosolic calcium levels
Any ryanodine-sensitive calcium-release channel activity that is involved in regulation of postsynaptic cytosolic calcium ion concentration.
GOC:dos
The aggregation, arrangement and bonding together of a set of components to form a postsynaptic specialization, a region that lies adjacent to the cytoplasmic face of the postsynaptic membrane.
dos
2017-04-04T17:22:01Z
biological_process
GO:0098698
postsynaptic specialization assembly
The aggregation, arrangement and bonding together of a set of components to form a postsynaptic specialization, a region that lies adjacent to the cytoplasmic face of the postsynaptic membrane.
GOC:dos
The action of a molecule that contributes to the structural integrity of a presynaptic actin cytoskeleton.
dos
2017-06-09T18:33:07Z
molecular_function
GO:0098699
structural constituent of presynaptic actin cytoskeleton
The action of a molecule that contributes to the structural integrity of a presynaptic actin cytoskeleton.
GOC:dos
The active transport of neurotransmitters into a synaptic vesicle. This import is fuelled by an electrochemical gradient across the vesicle membrane, established by the action of proton pumps.
neurotransmitter import into synaptic vesicle
neurotransmitter uptake into synaptic vesicle
synaptic vesicle neurotransmitter loading
biological_process
GO:0098700
neurotransmitter loading into synaptic vesicle
The active transport of neurotransmitters into a synaptic vesicle. This import is fuelled by an electrochemical gradient across the vesicle membrane, established by the action of proton pumps.
GOC:PARL
GOC:bf
GOC:pad
PMID:10099709
PMID:15217342
neurotransmitter uptake into synaptic vesicle
PMID:15217342
synaptic vesicle neurotransmitter loading
The part of a synapse that is part of the presynaptic cell.
presynaptic terminal
cellular_component
GO:0098793
presynapse
The part of a synapse that is part of the presynaptic cell.
GOC:dos
The part of a synapse that is part of the post-synaptic cell.
cellular_component
GO:0098794
postsynapse
The part of a synapse that is part of the post-synaptic cell.
GOC:dos
The directed movement of neurotransmitter molecules from the extrasynaptic space into the presynaptic cytosol.
biological_process
GO:0098810
neurotransmitter reuptake
The directed movement of neurotransmitter molecules from the extrasynaptic space into the presynaptic cytosol.
GOC:dos
The low level of synaptic transmission that occurs via spontaneous neurotransmitter release into the synaptic cleft in the absence of a presynaptic action potential.
basal synaptic transmission
biological_process
GO:0098814
This is typically measured via detection of mini excitatory post-synaptic currents (mEPSCs).
spontaneous synaptic transmission
The low level of synaptic transmission that occurs via spontaneous neurotransmitter release into the synaptic cleft in the absence of a presynaptic action potential.
PMID:20200227
basal synaptic transmission
PMID:16899074
A protein complex that spans the synaptic cleft and has parts in both the pre- and post-synaptic membranes.
cellular_component
GO:0098820
trans-synaptic protein complex
A protein complex that spans the synaptic cleft and has parts in both the pre- and post-synaptic membranes.
PMID:20200227
An endosome present in the presynapse that fuses with endocytic vesicles arising in the presynaptic endocytic zone. This organelle is believed to be involved in regeneration of synaptic vesicles.
cellular_component
GO:0098830
As of 2015, there is still controversy over the nature of presynaptic endosomes and their relationship to regular endosomes. See Jahne et al., 2015 (PMID:25939282) for details.
presynaptic endosome
An endosome present in the presynapse that fuses with endocytic vesicles arising in the presynaptic endocytic zone. This organelle is believed to be involved in regeneration of synaptic vesicles.
PMID:20200227
PMID:25939282
A specialized region below the presynaptic membrane, characterized by electron-dense material, a specialized cytoskeletal matrix and accumulated (associated) synaptic vesicles.
cortex of presynaptic active zone
presynaptic zone cortex
cellular_component
GO:0098831
presynaptic active zone cytoplasmic component
A specialized region below the presynaptic membrane, characterized by electron-dense material, a specialized cytoskeletal matrix and accumulated (associated) synaptic vesicles.
GOC:dos
A specialized region of the plasma membrane and underlying cytoplasm which surround the the active zone, into which synaptic vesicle membranes are recycled following exocytosis. It is especially enriched in endocytic proteins following intense activity.
cellular_component
GO:0098833
May be identical to periactive zone?
presynaptic endocytic zone
A specialized region of the plasma membrane and underlying cytoplasm which surround the the active zone, into which synaptic vesicle membranes are recycled following exocytosis. It is especially enriched in endocytic proteins following intense activity.
PMID:17455288
The cytoplasmic component of the presynaptic endocytic zone.
cortex of presynaptic endocytic zone
cellular_component
GO:0098834
presynaptic endocytic zone cytoplasmic component
The cytoplasmic component of the presynaptic endocytic zone.
GOC:dos
The region of the presynaptic membrane that is part of the presynaptic endocytic zone - where synaptic vesicles are endocytosed and recycled following release.
cellular_component
GO:0098835
presynaptic endocytic zone membrane
The region of the presynaptic membrane that is part of the presynaptic endocytic zone - where synaptic vesicles are endocytosed and recycled following release.
GOC:dos
A recycling endosome of the postsynapse. In postsynaptic terminals with dendritic spines, it is typically located at the base of a dendritic spine. It is involved in recycling of neurotransmitter receptors to the postsynaptic membrane. In some cases at least, this recycling is activated by postsynaptic signaling and so can play a role in long term potentiation.
postsynaptic endosomal recycling compartment
postsynaptic recycling outpost
cellular_component
GO:0098837
postsynaptic recycling endosome
A recycling endosome of the postsynapse. In postsynaptic terminals with dendritic spines, it is typically located at the base of a dendritic spine. It is involved in recycling of neurotransmitter receptors to the postsynaptic membrane. In some cases at least, this recycling is activated by postsynaptic signaling and so can play a role in long term potentiation.
PMID:20820847
postsynaptic endosomal recycling compartment
PMID:20820847
postsynaptic recycling outpost
PMID:20820847
The membrane component of the postsynaptic density. This is the region of the postsynaptic membrane in which the population of neurotransmitter receptors involved in synaptic transmission are concentrated.
cellular_component
GO:0098839
postsynaptic density membrane
The membrane component of the postsynaptic density. This is the region of the postsynaptic membrane in which the population of neurotransmitter receptors involved in synaptic transmission are concentrated.
GOC:dos
An early endosome of the postsynapse. It acts as the major sorting station on the endocytic pathway, targeting neurotransmitter receptors for degregation or recycling.
cellular_component
GO:0098842
Commonly used markers for postsynaptic early endosomes include RAB5A and EEA1.
postsynaptic early endosome
An early endosome of the postsynapse. It acts as the major sorting station on the endocytic pathway, targeting neurotransmitter receptors for degregation or recycling.
PMID:19603039
PMID:20820847
PMID:24727350
A stably positioned site of clathrin adjacent and physically attached to the postsynaptic specialization, which is the site of endocytosis of post-synaptic proteins.
cellular_component
GO:0098843
postsynaptic endocytic zone
A stably positioned site of clathrin adjacent and physically attached to the postsynaptic specialization, which is the site of endocytosis of post-synaptic proteins.
PMID:17880892
The region of the postsynaptic membrane that is part of the postsynaptic endocytic zone. This region of membrane is associated with stable clathrin puncta.
cellular_component
GO:0098844
postsynaptic endocytic zone membrane
The region of the postsynaptic membrane that is part of the postsynaptic endocytic zone. This region of membrane is associated with stable clathrin puncta.
PMID:17880892
An endosomal compartment that is part of the post-synapse. Only early and recycling endosomes are typically present in the postsynapse.
cellular_component
GO:0098845
postsynaptic endosome
An endosomal compartment that is part of the post-synapse. Only early and recycling endosomes are typically present in the postsynapse.
PMID:20820847
The component of the synaptic vesicle membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
cellular_component
GO:0098850
extrinsic component of synaptic vesicle membrane
The component of the synaptic vesicle membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
GOC:dos
The actin cytoskeleton that is part of a postsynapse.
cellular_component
GO:0098871
postsynaptic actin cytoskeleton
The actin cytoskeleton that is part of a postsynapse.
GOC:dos
A G protein-coupled neurotransmitter receptor activity occurring in the postsynaptic membrane, that is involved in regulating the cytosolic concentration of calcium ions in the postsynapse.
G-protein coupled neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration
G-protein coupled neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium levels
molecular_function
GO:0098872
G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration
A G protein-coupled neurotransmitter receptor activity occurring in the postsynaptic membrane, that is involved in regulating the cytosolic concentration of calcium ions in the postsynapse.
GOC:dos
G-protein coupled neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium levels
The directed movement of neurotransmitter receptor to the plasma membrane in transport vesicles.
biological_process
GO:0098877
neurotransmitter receptor transport to plasma membrane
The directed movement of neurotransmitter receptor to the plasma membrane in transport vesicles.
GOC:dos
The action of a molecule that contributes to the structural integrity of a postsynaptic specialization.
molecular_function
GO:0098879
structural constituent of postsynaptic specialization
The action of a molecule that contributes to the structural integrity of a postsynaptic specialization.
GOC:dos
A process which maintains the organization and the arrangement of proteins in the presynaptic specialization.
biological_process
GO:0098880
maintenance of postsynaptic specialization structure
A process which maintains the organization and the arrangement of proteins in the presynaptic specialization.
GOC:dos
The exocytic fusion of neurotransmitter receptor-containing vesicles with plasma membrane, resulting in the integration of neurotransmitter receptors into the plasma membrane. This process includes tethering and docking steps that prepare vesicles for fusion.
neurotransmitter receptor insertion
biological_process
GO:0098881
exocytic insertion of neurotransmitter receptor to plasma membrane
The exocytic fusion of neurotransmitter receptor-containing vesicles with plasma membrane, resulting in the integration of neurotransmitter receptors into the plasma membrane. This process includes tethering and docking steps that prepare vesicles for fusion.
GOC:aruk
GOC:bc
PMID:19503082
The action of a molecule that contributes to the structural integrity of a presynaptic active zone.
structural constituent of active zone
molecular_function
GO:0098882
structural constituent of presynaptic active zone
The action of a molecule that contributes to the structural integrity of a presynaptic active zone.
GOC:dos
structural constituent of active zone
A cellular process that results in the controlled breakdown of synapse. After it starts the process is continuous until the synapse has disappeared.
synapse clearance
synapse disassembly
synapse elimination
synapse removal
biological_process
GO:0098883
synapse pruning
A cellular process that results in the controlled breakdown of synapse. After it starts the process is continuous until the synapse has disappeared.
GOC:dos
PMID:12062020
PMID:18083105
PMID:22632716
PMID:29844190
synapse clearance
GOC:aruk
GOC:bc
PMID:22632716
synapse disassembly
PMID:12062020
synapse elimination
GOC:aruk
GOC:bc
PMID:18083105
PMID:29844190
synapse removal
GOC:aruk
GOC:bc
PMID:22632716
A receptor-mediated endocytosis process that results in the internalization of a neurotransmitter receptor from the postsynaptic membrane endocytic zone into an endocytic vesicle.
https://github.com/geneontology/synapse/issues/230
postsynaptic neurotransmitter receptor endocytosis
biological_process
GO:0098884
postsynaptic neurotransmitter receptor internalization
A receptor-mediated endocytosis process that results in the internalization of a neurotransmitter receptor from the postsynaptic membrane endocytic zone into an endocytic vesicle.
GOC:dos
postsynaptic neurotransmitter receptor endocytosis
Any process that modifies the structure of a postsynaptic actin cytoskeleton.
postsynaptic actin cytoskeleton remodelling
biological_process
GO:0098885
This class does not cover assembly or disassembly of synapses, only the modification/remodelling of existing ones.
modification of postsynaptic actin cytoskeleton
Any process that modifies the structure of a postsynaptic actin cytoskeleton.
GOC:dos
The directed movement of neurotransmitter receptor from the postsynaptic endosome to the postsynaptic membrane in transport vesicles.
postsynaptic neurotransmitter receptor endosomal trafficking
biological_process
GO:0098887
neurotransmitter receptor transport, endosome to postsynaptic membrane
The directed movement of neurotransmitter receptor from the postsynaptic endosome to the postsynaptic membrane in transport vesicles.
GOC:dos
The component of the presynaptic membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
extrinsic component of presynaptic plasma membrane
cellular_component
GO:0098888
extrinsic component of presynaptic membrane
The component of the presynaptic membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
GOC:autophagy
GOC:mf
The component of the postsynaptic membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
cellular_component
GO:0098890
extrinsic component of postsynaptic membrane
The component of the postsynaptic membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
GOC:autophagy
GOC:mf
The component of the presynaptic active zone membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
cellular_component
GO:0098891
extrinsic component of presynaptic active zone membrane
The component of the presynaptic active zone membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
GOC:autophagy
GOC:mf
The component of the postsynaptic specialization membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
cellular_component
GO:0098892
extrinsic component of postsynaptic specialization membrane
The component of the postsynaptic specialization membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
GOC:autophagy
GOC:mf
The component of the postsynaptic endocytic zone membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
cellular_component
GO:0098893
extrinsic component of postsynaptic endocytic zone
The component of the postsynaptic endocytic zone membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
GOC:autophagy
GOC:mf
The component of the presynaptic endocytic zone membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
cellular_component
GO:0098894
extrinsic component of presynaptic endocytic zone membrane
The component of the presynaptic endocytic zone membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
GOC:autophagy
GOC:mf
The lipid bilayer surrounding a postsynaptic endosome.
cellular_component
GO:0098895
postsynaptic endosome membrane
The lipid bilayer surrounding a postsynaptic endosome.
GOC:pz
The lipid bilayer surrounding a postsynaptic early endosome.
cellular_component
GO:0098896
postsynaptic early endosome membrane
The lipid bilayer surrounding a postsynaptic early endosome.
GOC:pz
The lipid bilayer surrounding the spine apparatus.
cellular_component
GO:0098897
spine apparatus membrane
The lipid bilayer surrounding the spine apparatus.
GOC:mah
The volume enclosed by the spine apparatus membrane.
cellular_component
GO:0098899
spine apparatus lumen
The volume enclosed by the spine apparatus membrane.
GOC:dos
The action of a molecule that contributes to the structural integrity of a synapse.
molecular_function
GO:0098918
structural constituent of synapse
The action of a molecule that contributes to the structural integrity of a synapse.
GOC:dos
The action of a molecule that contributes to the structural integrity of a postsynaptic density.
molecular_function
GO:0098919
structural constituent of postsynaptic density
The action of a molecule that contributes to the structural integrity of a postsynaptic density.
GOC:dos
Cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by a lipid ligand.
biological_process
GO:0098920
retrograde trans-synaptic signaling by lipid
Cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by a lipid ligand.
GOC:dos
Cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by an endocannabinoid ligand.
biological_process
GO:0098921
retrograde trans-synaptic signaling by endocannabinoid
Cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by an endocannabinoid ligand.
GOC:dos
Cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by an soluble gas ligand.
biological_process
GO:0098923
retrograde trans-synaptic signaling by soluble gas
Cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by an soluble gas ligand.
GOC:dos
Cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by nitric oxide.
biological_process
GO:0098924
retrograde trans-synaptic signaling by nitric oxide
Cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by nitric oxide.
GOC:dos
Modulation of synaptic transmission by cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by nitric oxide.
biological_process
GO:0098925
Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
retrograde trans-synaptic signaling by nitric oxide, modulating synaptic transmission
Modulation of synaptic transmission by cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by nitric oxide.
GOC:dos
Signal transduction in which the initial step occurs in a postsynapse.
postsynaptic signaling pathway
biological_process
GO:0098926
postsynaptic signal transduction
Signal transduction in which the initial step occurs in a postsynapse.
GOC:dos
postsynaptic signaling pathway
Signal transduction in which the initial step occurs in a presynapse.
presynaptic signaling pathway
biological_process
GO:0098928
presynaptic signal transduction
Signal transduction in which the initial step occurs in a presynapse.
GOC:dos
presynaptic signaling pathway
The directed movement of organelles or molecules along microtubules in axons.
Wikipedia:Axoplasmic_transport
axon cargo transport
axoplasmic transport
biological_process
GO:0098930
axonal transport
The directed movement of organelles or molecules along microtubules in axons.
ISBN:0815316194
The directed movement of organelles or molecules along microtubules in a dendrite from the postsynapse towards the cell body.
biological_process
GO:0098934
retrograde dendritic transport
The directed movement of organelles or molecules along microtubules in a dendrite from the postsynapse towards the cell body.
GOC:dos
The directed movement of organelles or molecules along microtubules in dendrites.
dendrite cargo transport
biological_process
GO:0098935
dendritic transport
The directed movement of organelles or molecules along microtubules in dendrites.
ISBN:0815316194
The directed movement of organelles or molecules along microtubules from the cell body toward the postsynapse in dendrites.
biological_process
GO:0098937
anterograde dendritic transport
The directed movement of organelles or molecules along microtubules from the cell body toward the postsynapse in dendrites.
ISBN:0815316194
The actin cytoskeleton that is part of a dendritic spine.
cellular_component
GO:0098938
actin cytoskeleton of dendritic spine
The actin cytoskeleton that is part of a dendritic spine.
GOC:dos
The directed movement of mitochondria along microtubules in nerve cell dendrites.
biological_process
GO:0098939
dendritic transport of mitochondrion
The directed movement of mitochondria along microtubules in nerve cell dendrites.
GOC:ai
Cell-cell signaling from presynapse to postynapse, across the synaptic cleft, mediated by nitric oxide.
biological_process
GO:0098940
anterograde trans-synaptic signaling by nitric oxide
Cell-cell signaling from presynapse to postynapse, across the synaptic cleft, mediated by nitric oxide.
GOC:dos
Cell-cell signaling from presynapse to postynapse, across the synaptic cleft, mediated by a trans-synaptic protein complex.
biological_process
GO:0098941
anterograde trans-synaptic signaling by trans-synaptic protein complex
Cell-cell signaling from presynapse to postynapse, across the synaptic cleft, mediated by a trans-synaptic protein complex.
GOC:dos
Cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by trans-synaptic protein complex.
biological_process
GO:0098942
retrograde trans-synaptic signaling by trans-synaptic protein complex
Cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by trans-synaptic protein complex.
GOC:dos
The directed movement of neurotransmitter receptor from the postsynaptic endosome in tranpsort vesicles to the lysosome for degradation.
postsynaptic neurotransmitter receptor endosomal trafficking
biological_process
GO:0098943
neurotransmitter receptor transport, postsynaptic endosome to lysosome
The directed movement of neurotransmitter receptor from the postsynaptic endosome in tranpsort vesicles to the lysosome for degradation.
GOC:dos
The lipid bilayer surrounding a postsynaptic recycling endosome.
cellular_component
GO:0098944
postsynaptic recycling endosome membrane
The lipid bilayer surrounding a postsynaptic recycling endosome.
GOC:pz
The lipid bilayer surrounding a presynaptic endosome.
cellular_component
GO:0098954
presynaptic endosome membrane
The lipid bilayer surrounding a presynaptic endosome.
GOC:pz
The directed movement of mitochondria along microtubules in axons away from the cell body and towards the presynapse.
anterograde axon transport of mitochondria
biological_process
GO:0098957
anterograde axonal transport of mitochondrion
The directed movement of mitochondria along microtubules in axons away from the cell body and towards the presynapse.
GOC:dos
The directed movement of mitochondria along microtubules in axons towards the cell body and away from the presynapse.
retrograde axon transport of mitochondria
biological_process
GO:0098958
retrograde axonal transport of mitochondrion
The directed movement of mitochondria along microtubules in axons towards the cell body and away from the presynapse.
GOC:dos
The directed movement of mitochondria along microtubules in dendrites towards the cell body and away from the postsynapse.
retrograde dendrite transport of mitochondria
biological_process
GO:0098959
retrograde dendritic transport of mitochondrion
The directed movement of mitochondria along microtubules in dendrites towards the cell body and away from the postsynapse.
GOC:dos
The directed movement of a ribonucleoprotein complex along microtubules in nerve cell dendrites.
dendritic transport of RNP complex
biological_process
GO:0098961
dendritic transport of ribonucleoprotein complex
The directed movement of a ribonucleoprotein complex along microtubules in nerve cell dendrites.
GOC:dos
Any process that modulates the frequency, rate or extent of neurotransmitter receptor activity involved in synaptic transmission. Modulation may be via an effect on ligand affinity, or effector funtion such as ion selectivity or pore opening/closing in ionotropic receptors.
biological_process
GO:0098962
regulation of postsynaptic neurotransmitter receptor activity
Any process that modulates the frequency, rate or extent of neurotransmitter receptor activity involved in synaptic transmission. Modulation may be via an effect on ligand affinity, or effector funtion such as ion selectivity or pore opening/closing in ionotropic receptors.
GOC:dos
The directed movement of a messenger ribonucleoprotein complex along microtubules in nerve cell dendrites.
dendritic transport of mRNA RNP complex
biological_process
GO:0098963
dendritic transport of messenger ribonucleoprotein complex
The directed movement of a messenger ribonucleoprotein complex along microtubules in nerve cell dendrites.
GOC:dos
The directed movement of a messenger ribonucleoprotein complex along microtubules in nerve cell dendrites towards the postsynapse.
anterograde dendritic transport of mRNA RNP complex
biological_process
GO:0098964
anterograde dendritic transport of messenger ribonucleoprotein complex
The directed movement of a messenger ribonucleoprotein complex along microtubules in nerve cell dendrites towards the postsynapse.
GOC:dos
The portion of the extracellular matrix that lies within the synaptic cleft.
ECM of synaptic cleft
synaptic cleft ECM
cellular_component
GO:0098965
extracellular matrix of synaptic cleft
The portion of the extracellular matrix that lies within the synaptic cleft.
GOC:dos
The portion of the extracellular matrix that lies within the perisynaptic space.
extrasynaptic extracellular matrix
perisynaptic ECM
cellular_component
GO:0098966
perisynaptic extracellular matrix
The portion of the extracellular matrix that lies within the perisynaptic space.
GOC:dos
The exocytic fusion of neurotransmitter receptor containing vesicles with the postsynaptic membrane resulting in the integration of NT receptors, enabling them to participate in neurotransmitter reception. This process includes tethering and docking steps that prepare vesicles for fusion.
biological_process
GO:0098967
exocytic insertion of neurotransmitter receptor to postsynaptic membrane
The exocytic fusion of neurotransmitter receptor containing vesicles with the postsynaptic membrane resulting in the integration of NT receptors, enabling them to participate in neurotransmitter reception. This process includes tethering and docking steps that prepare vesicles for fusion.
PMID:19503082
Vesicle-mediated transport of a neurotransmitter receptor complex from the postsynaptic membrane to the postsynaptic early endosome.
biological_process
GO:0098968
neurotransmitter receptor transport postsynaptic membrane to endosome
Vesicle-mediated transport of a neurotransmitter receptor complex from the postsynaptic membrane to the postsynaptic early endosome.
GOC:dos
The directed movement of neurotransmitter receptor to the postsynaptic membrane in transport vesicles.
biological_process
GO:0098969
neurotransmitter receptor transport to postsynaptic membrane
The directed movement of neurotransmitter receptor to the postsynaptic membrane in transport vesicles.
GOC:dos
The process by which diffusing neurotransmitter receptor becomes trapped at the postsynaptic specialization membrane. This is typically due to interaction with components of the post-synaptic specialization.
biological_process
GO:0098970
postsynaptic neurotransmitter receptor diffusion trapping
The process by which diffusing neurotransmitter receptor becomes trapped at the postsynaptic specialization membrane. This is typically due to interaction with components of the post-synaptic specialization.
PMID:18832033
The directed movement of a neurotransmitter receptor complex along microtubules in nerve cell dendrites towards the postsynapse.
biological_process
GO:0098971
anterograde dendritic transport of neurotransmitter receptor complex
The directed movement of a neurotransmitter receptor complex along microtubules in nerve cell dendrites towards the postsynapse.
GOC:dos
The directed movement of mitochondria along microtubules in dendrites towards the postsynapse and away from the cell body.
biological_process
GO:0098972
anterograde dendritic transport of mitochondrion
The directed movement of mitochondria along microtubules in dendrites towards the postsynapse and away from the cell body.
GOC:dos
The action of a molecule that contributes to the structural integrity of a postsynaptic actin cytoskeleton.
molecular_function
GO:0098973
structural constituent of postsynaptic actin cytoskeleton
The action of a molecule that contributes to the structural integrity of a postsynaptic actin cytoskeleton.
GOC:dos
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins in the postsynaptic actin cytoskeleton.
biological_process
GO:0098974
postsynaptic actin cytoskeleton organization
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins in the postsynaptic actin cytoskeleton.
GOC:dos
A synapse that uses glutamate as a neurotransmitter.
cellular_component
GO:0098978
glutamatergic synapse
A synapse that uses glutamate as a neurotransmitter.
GOC:dos
A synapse that uses acetylcholine as a neurotransmitter.
cellular_component
GO:0098981
cholinergic synapse
A synapse that uses acetylcholine as a neurotransmitter.
GOC:dos
A synapse that uses GABA as a neurotransmitter. These synapses are typically inhibitory.
cellular_component
GO:0098982
GABA-ergic synapse
A synapse that uses GABA as a neurotransmitter. These synapses are typically inhibitory.
GOC:dos
Any process that regulates the modification of synaptic structure and as a result regulates synaptic transmission.
biological_process
GO:0098987
Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
regulation of modification of synapse structure, modulating synaptic transmission
Any process that regulates the modification of synaptic structure and as a result regulates synaptic transmission.
GOC:dos
The series of molecular signals initiated by glutamate binding to an AMPA-selective glutamate receptor on the surface of the target cell, followed by the movement of ions through a channel in the receptor complex, and ending with the regulation of a downstream cellular process, e.g. transcription.
biological_process
GO:0098990
AMPA selective glutamate receptor signaling pathway
The series of molecular signals initiated by glutamate binding to an AMPA-selective glutamate receptor on the surface of the target cell, followed by the movement of ions through a channel in the receptor complex, and ending with the regulation of a downstream cellular process, e.g. transcription.
GOC:dos
ISBN:9780071120005
The series of molecular signals initiated by glutamate binding to an kainate-selective glutamate receptor on the surface of the target cell, followed by the movement of ions through a channel in the receptor complex, ending with the regulation of a downstream cellular process, e.g. transcription.
biological_process
GO:0098991
kainate selective glutamate receptor signaling pathway
The series of molecular signals initiated by glutamate binding to an kainate-selective glutamate receptor on the surface of the target cell, followed by the movement of ions through a channel in the receptor complex, ending with the regulation of a downstream cellular process, e.g. transcription.
GOC:signaling
ISBN:9780071120005
A dense core vesicle (granule) that is part of a neuron. These vesicles typically contain neuropeptides. They can be found in all parts of neurons, including the soma, dendrites, axonal swellings (varicosities) and synaptic terminals.
cellular_component
GO:0098992
neuronal dense core vesicle
A dense core vesicle (granule) that is part of a neuron. These vesicles typically contain neuropeptides. They can be found in all parts of neurons, including the soma, dendrites, axonal swellings (varicosities) and synaptic terminals.
GOC:dos
ISBN:978-0-07-181001-2
Wikipedia:Neuropeptide&oldid=713905176
The component of the postsynaptic early endosome membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
cellular_component
GO:0098998
extrinsic component of postsynaptic early endosome membrane
The component of the postsynaptic early endosome membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
GOC:autophagy
GOC:mf
The component of the postsynaptic endosome membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
cellular_component
GO:0098999
extrinsic component of postsynaptic endosome membrane
The component of the postsynaptic endosome membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
GOC:autophagy
GOC:mf
Any vesicle-mediated transport that occurs in a synapse.
biological_process
GO:0099003
vesicle-mediated transport in synapse
Any vesicle-mediated transport that occurs in a synapse.
GOC:dos
The component of the postsynaptic recycling endosome membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
cellular_component
GO:0099005
extrinsic component of postsynaptic recycling endosome membrane
The component of the postsynaptic recycling endosome membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
GOC:autophagy
GOC:mf
The component of the presynaptic endosome membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
cellular_component
GO:0099007
extrinsic component of presynaptic endosome membrane
The component of the presynaptic endosome membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
GOC:autophagy
GOC:mf
Any process that modifies the structure of a postsynapse.
synapse remodelling
biological_process
GO:0099010
This class does not cover assembly or disassembly of postsynapses, only the modification/remodelling of existing ones.
modification of postsynaptic structure
Any process that modifies the structure of a postsynapse.
GOC:dos
The lipid bilayer surrounding a neuronal dense core vesicle.
cellular_component
GO:0099012
neuronal dense core vesicle membrane
The lipid bilayer surrounding a neuronal dense core vesicle.
GOC:dos
The volume enclosed by a neuronal dense core vesicle membrane.
cellular_component
GO:0099013
neuronal dense core vesicle lumen
The volume enclosed by a neuronal dense core vesicle membrane.
GOC:dos
The aggregation, arrangement and bonding together of a set of components to form a presynapse.
presynapse biogenesis
presynaptic terminal assembly
biological_process
GO:0099054
presynapse assembly
The aggregation, arrangement and bonding together of a set of components to form a presynapse.
GOC:PARL
GOC:bf
GOC:dos
PMID:24449494
presynapse biogenesis
GOC:mah
presynaptic terminal assembly
PMID:24449494
Any process that regulates the the local concentration of neurotransmitter receptor at the postsynaptic membrane.
biological_process
GO:0099072
regulation of postsynaptic membrane neurotransmitter receptor levels
Any process that regulates the the local concentration of neurotransmitter receptor at the postsynaptic membrane.
GOC:dos
Cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by a neuropeptide.
biological_process
GO:0099082
retrograde trans-synaptic signaling by neuropeptide
Cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by a neuropeptide.
GOC:PARL
GOC:bf
GOC:dos
PMID:19448629
Modulation of synaptic transmittion by cell-cell signaling across the synaptic cleft from postsynapse to presynapse, mediated by a neuropeptide.
biological_process
GO:0099083
Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
retrograde trans-synaptic signaling by neuropeptide, modulating synaptic transmission
Modulation of synaptic transmittion by cell-cell signaling across the synaptic cleft from postsynapse to presynapse, mediated by a neuropeptide.
GOC:PARL
GOC:bf
GOC:dos
PMID:19448629
A process that results in the assembly, arrangement of constituent parts, or disassembly of a postsynaptic specialization, a structure that lies adjacent to the cytoplasmic face of the postsynaptic membrane.
pr
2011-07-27T05:17:12Z
post synaptic specialization organization
post-synaptic specialization organization
postsynaptic specialization organisation
biological_process
GO:0099084
postsynaptic specialization organization
A process that results in the assembly, arrangement of constituent parts, or disassembly of a postsynaptic specialization, a structure that lies adjacent to the cytoplasmic face of the postsynaptic membrane.
GOC:BHF
GOC:sjp
PMID:21525273
PMID:26834556
The directed movement of a messenger ribonucleoprotein complex along microtubules in axons, towards the presynapse.
anterograde axonal transport of mRNA RNP complex
biological_process
GO:0099087
anterograde axonal transport of messenger ribonucleoprotein complex
The directed movement of a messenger ribonucleoprotein complex along microtubules in axons, towards the presynapse.
GOC:dos
PMID:26586091
The directed movement of a messenger ribonucleoprotein complex along microtubules in axons.
axonal transport of mRNA RNP complex
biological_process
GO:0099088
axonal transport of messenger ribonucleoprotein complex
The directed movement of a messenger ribonucleoprotein complex along microtubules in axons.
GOC:dos
PMID:26586091
The directed movement of endoplasmic reticulum into a postsynaptic compartment such as a dendritic spine.
establishment of ER localization to postsynapse
biological_process
GO:0099089
establishment of endoplasmic reticulum localization to postsynapse
The directed movement of endoplasmic reticulum into a postsynaptic compartment such as a dendritic spine.
GOC:dos
PMID:21151132
establishment of ER localization to postsynapse
GOC:dos
A network of proteins adjacent to the postsynaptic membrane. Its major components include the proteins that spatially and functionally organize neurotransmitter receptors in the adjacent membrane, such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components.
cellular_component
GO:0099091
postsynaptic specialization, intracellular component
A network of proteins adjacent to the postsynaptic membrane. Its major components include the proteins that spatially and functionally organize neurotransmitter receptors in the adjacent membrane, such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components.
GOC:dos
A network of proteins adjacent to the postsynaptic membrane forming an electron dense disc. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize neurotransmitter receptors in the adjacent membrane, such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components.
cellular_component
GO:0099092
postsynaptic density, intracellular component
A network of proteins adjacent to the postsynaptic membrane forming an electron dense disc. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize neurotransmitter receptors in the adjacent membrane, such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components.
GOC:dos
Any G-protein gated potassium channel activity that is involved regulation of postsynaptic membrane potential.
molecular_function
GO:0099102
G-protein gated potassium channel activity involved in regulation of postsynaptic membrane potential
Any G-protein gated potassium channel activity that is involved regulation of postsynaptic membrane potential.
GOC:dos
PMID:9429760
Activation potassium ion channel activity via direct interaction with a potassium ion channel during G protein-coupled receptor signaling.
potassium channel activator activity involved in G-protein coupled receptor signaling pathway
molecular_function
GO:0099108
Examples include G-protein beta-gamma complexes that bind to and activate potassium channels.
potassium channel activator activity involved in G protein-coupled receptor signaling pathway
Activation potassium ion channel activity via direct interaction with a potassium ion channel during G protein-coupled receptor signaling.
PMID:9429760
Any process that decreases the concentration of calcium ions in the presynaptic cytosol.
biological_process
GO:0099113
negative regulation of presynaptic cytosolic calcium concentration
Any process that decreases the concentration of calcium ions in the presynaptic cytosol.
GOC:dos
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins in the presynaptic actin cytoskeleton.
dos
2017-06-09T18:34:19Z
biological_process
GO:0099140
presynaptic actin cytoskeleton organization
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins in the presynaptic actin cytoskeleton.
GOC:dos
The actin cytoskeleton that is part of a presynapse.
dos
2017-06-09T18:36:19Z
cellular_component
GO:0099143
presynaptic actin cytoskeleton
The actin cytoskeleton that is part of a presynapse.
GOC:dos
Any process that modulates the frequency, rate or extent of exocytic fusion of neurotransmitter receptor containing vesicles into the postsynaptic membrane.
dos
2017-06-09T18:49:26Z
biological_process
GO:0099145
regulation of exocytic insertion of neurotransmitter receptor to postsynaptic membrane
Any process that modulates the frequency, rate or extent of exocytic fusion of neurotransmitter receptor containing vesicles into the postsynaptic membrane.
GOC:dos
The component of the postsynaptic density membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
dos
2017-07-05T10:44:43Z
cellular_component
GO:0099147
extrinsic component of postsynaptic density membrane
The component of the postsynaptic density membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
GOC:autophagy
GOC:mf
Any process that modulates the frequency, rate or extent of synaptic vesicle docking.
dos
2017-07-05T13:10:10Z
biological_process
GO:0099148
regulation of synaptic vesicle docking
Any process that modulates the frequency, rate or extent of synaptic vesicle docking.
GOC:dos
Any process that modulates the frequency, rate or extent of endocytosis of neurotransmitter receptor at the postsynapse.
dos
2017-07-05T13:13:49Z
regulation of postsynaptic neurotransmitter receptor endocytosis
biological_process
GO:0099149
regulation of postsynaptic neurotransmitter receptor internalization
Any process that modulates the frequency, rate or extent of endocytosis of neurotransmitter receptor at the postsynapse.
GOC:ai
regulation of postsynaptic neurotransmitter receptor endocytosis
Any process that modulates the frequency, rate or extent of postsynaptic specialization assembly, the aggregation, arrangement and bonding together of a set of components to form a postsynaptic specialization.
dos
2017-07-05T13:20:48Z
biological_process
GO:0099150
regulation of postsynaptic specialization assembly
Any process that modulates the frequency, rate or extent of postsynaptic specialization assembly, the aggregation, arrangement and bonding together of a set of components to form a postsynaptic specialization.
GOC:dos
Any process that modulates the frequency, rate or extent of postsynaptic density assembly, the aggregation, arrangement and bonding together of a set of components to form a postsynaptic density.
dos
2017-07-05T13:20:48Z
biological_process
GO:0099151
regulation of postsynaptic density assembly
Any process that modulates the frequency, rate or extent of postsynaptic density assembly, the aggregation, arrangement and bonding together of a set of components to form a postsynaptic density.
GOC:dos
Any process that modulates the frequency, rate or extent of the directed movement of neurotransmitter receptor from the postsynaptic endosome to the postsynaptic membrane in transport vesicles.
dos
2017-08-25T15:01:11Z
biological_process
GO:0099152
regulation of neurotransmitter receptor transport, endosome to postsynaptic membrane
Any process that modulates the frequency, rate or extent of the directed movement of neurotransmitter receptor from the postsynaptic endosome to the postsynaptic membrane in transport vesicles.
GOC:dos
PMID:20098723
A synapse that uses serotonin as a neurotransmitter.
dos
2017-07-05T14:22:05Z
cellular_component
GO:0099154
serotonergic synapse
A synapse that uses serotonin as a neurotransmitter.
GOC:dos
Transynaptic signaling in which the ligand is carried across the synapse by an exosome.
dos
2017-07-05T16:49:44Z
exosome mediated transynaptic signalling
trans-synaptic signalling via exosome
biological_process
GO:0099157
trans-synaptic signaling via exosome
Transynaptic signaling in which the ligand is carried across the synapse by an exosome.
GOC:dos
PMID:19837038
Any process that modulates the frequency, rate or extent of transport or maintenance of location of a postsynaptic recycling endosome within the postsynapse.
dos
2017-08-25T15:37:50Z
biological_process
GO:0099158
regulation of recycling endosome localization within postsynapse
Any process that modulates the frequency, rate or extent of transport or maintenance of location of a postsynaptic recycling endosome within the postsynapse.
GOC:dos
PMID:20098723
Any process that modulates the frequency, rate or extent of modification of postsynaptic structure.
dos
2017-08-25T15:47:55Z
regulation of postsynapse remodelling
biological_process
GO:0099159
regulation of modification of postsynaptic structure
Any process that modulates the frequency, rate or extent of modification of postsynaptic structure.
GOC:dos
The intermediate filament cytoskeleton that is part of a postsynapse.
dos
2017-08-28T15:26:08Z
cellular_component
GO:0099160
postsynaptic intermediate filament cytoskeleton
The intermediate filament cytoskeleton that is part of a postsynapse.
GOC:dos
PMID:25869803
Any process that modulates the frequency, rate or extent of presynaptic dense core granule exocytosis.
dos
2017-09-10T10:59:08Z
regulation of presynaptic dense core vesicle exocytosis
biological_process
GO:0099161
regulation of presynaptic dense core granule exocytosis
Any process that modulates the frequency, rate or extent of presynaptic dense core granule exocytosis.
GOC:dos
PMID:17881523
regulation of presynaptic dense core vesicle exocytosis
Any process that modulates the frequency, rate or extent of neurotransmitter loading into synaptic vesicles.
dos
2017-09-10T11:07:57Z
regulation of neurotransmitter uptake into synaptic vesicle
regulation of synaptic vesicle neurotransmitter loading
biological_process
GO:0099162
regulation of neurotransmitter loading into synaptic vesicle
Any process that modulates the frequency, rate or extent of neurotransmitter loading into synaptic vesicles.
GOC:dos
PMID:25176177
regulation of neurotransmitter uptake into synaptic vesicle
PMID:15217342
regulation of synaptic vesicle neurotransmitter loading
Cell-cell signaling to or from a synapse, mediated by nitric oxide.
biological_process
GO:0099163
synaptic signaling by nitric oxide
Cell-cell signaling to or from a synapse, mediated by nitric oxide.
GOC:dos
PMID:19038221
The membrane component of the postsynaptic specialization of a symmetic synapse. This is the region of the postsynaptic membrane in which the population of neurotransmitter receptors involved in synaptic transmission are concentrated.
dos
2017-09-10T11:50:44Z
cellular_component
GO:0099164
postsynaptic specialization membrane of symmetric synapse
The membrane component of the postsynaptic specialization of a symmetic synapse. This is the region of the postsynaptic membrane in which the population of neurotransmitter receptors involved in synaptic transmission are concentrated.
GOC:dos
A network of proteins adjacent to the postsynaptic membrane of a symmetric synapse. Its major components include that spatially and functionally organize neurotransmitter receptors in the adjacent membrane, such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components. This structure is not as thick or electron dense as the postsynaptic density found in asymmetric synapses.
dos
2017-09-10T11:54:15Z
cellular_component
GO:0099165
postsynaptic specialization of symmetric synapse, intracellular component
A network of proteins adjacent to the postsynaptic membrane of a symmetric synapse. Its major components include that spatially and functionally organize neurotransmitter receptors in the adjacent membrane, such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components. This structure is not as thick or electron dense as the postsynaptic density found in asymmetric synapses.
GOC:dos
Any process, acting in the postsynapse that results in modulation of chemical synaptic transmission.
dos
2017-09-11T17:09:17Z
biological_process
GO:0099170
postsynaptic modulation of chemical synaptic transmission
Any process, acting in the postsynapse that results in modulation of chemical synaptic transmission.
GOC:dos
Any process, acting in the presynapse that results in modulation of chemical synaptic transmission.
dos
2017-09-11T17:09:31Z
biological_process
GO:0099171
presynaptic modulation of chemical synaptic transmission
Any process, acting in the presynapse that results in modulation of chemical synaptic transmission.
GOC:dos
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a presynapse.
presynapse development
presynapse organisation
biological_process
presynapse morphogenesis
presynapse organization and biogenesis
GO:0099172
presynapse organization
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a presynapse.
GOC:dos
presynapse morphogenesis
GOC:BHF
presynapse organization and biogenesis
GOC:mah
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a postsynapse.
postsynapse development
postsynapse organisation
biological_process
postsynapse morphogenesis
postsynapse organization and biogenesis
GO:0099173
postsynapse organization
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a postsynapse.
GOC:dos
postsynapse morphogenesis
GOC:BHF
postsynapse organization and biogenesis
GOC:mah
Any process that modulates the physical form of a presynapse.
regulation of presynapse organisation
regulation of presynapse structure
biological_process
regulation of presynapse organization and biogenesis
GO:0099174
regulation of presynapse organization
Any process that modulates the physical form of a presynapse.
GOC:ai
GOC:dph
GOC:tb
regulation of presynapse organisation
GOC:mah
regulation of presynapse organization and biogenesis
GOC:mah
Any process that modulates the physical form of a postsynapse.
regulation of postsynapse organisation
regulation of postsynapse structure
biological_process
regulation of postsynapse organization and biogenesis
GO:0099175
regulation of postsynapse organization
Any process that modulates the physical form of a postsynapse.
GOC:ai
GOC:dph
GOC:tb
regulation of postsynapse organisation
GOC:mah
regulation of postsynapse organization and biogenesis
GOC:mah
Any process that modulates the frequency, rate or extent of retrograde trans-synaptic signaling by a trans-synaptic complex.
biological_process
regulation of trans-synaptic complex mediated retrograde trans-synaptic signaling
GO:0099176
regulation of retrograde trans-synaptic signaling by trans-synaptic protein complex
Any process that modulates the frequency, rate or extent of retrograde trans-synaptic signaling by a trans-synaptic complex.
GOC:dos
PMID:23209303
regulation of trans-synaptic complex mediated retrograde trans-synaptic signaling
GOC:bf
Any process that modulates the frequency, rate or extent of adhesion between pre- and post-synaptic membranes.
regulation of synapse adhesion between pre- and post-synapse
biological_process
GO:0099179
regulation of synaptic membrane adhesion
Any process that modulates the frequency, rate or extent of adhesion between pre- and post-synaptic membranes.
GOC:dos
regulation of synapse adhesion between pre- and post-synapse
The directed movement of Zn2+ ions from the cytoplasm into the lumen of a cytoplasmic vesicle.
Zn2+ import into synaptic vesicle
zinc import into synaptic vesicle
biological_process
GO:0099180
zinc ion import into synaptic vesicle
The directed movement of Zn2+ ions from the cytoplasm into the lumen of a cytoplasmic vesicle.
PMID:9990090
The action of a molecule that contributes to the structural integrity of a presynapse.
dos
2017-12-20T13:42:46Z
molecular_function
GO:0099181
structural constituent of presynapse
The action of a molecule that contributes to the structural integrity of a presynapse.
GOC:dos
PMID:23751498
The intermediate filament cytoskeleton that is part of a presynapse.
dos
2017-12-01T18:10:21Z
cellular_component
GO:0099182
presynaptic intermediate filament cytoskeleton
The intermediate filament cytoskeleton that is part of a presynapse.
GOC:dos
Cell-cell signaling between presynapse and postsynapse, via the vesicular release and reception of brain derived neurotrophic factor (BDNF), that modulates the synaptic transmission properties of the synapse.
dos
2017-12-01T18:25:24Z
biological_process
GO:0099183
Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
trans-synaptic signaling by BDNF, modulating synaptic transmission
Cell-cell signaling between presynapse and postsynapse, via the vesicular release and reception of brain derived neurotrophic factor (BDNF), that modulates the synaptic transmission properties of the synapse.
GOC:dos
The action of a molecule that contributes to the structural integrity of a postsynaptic intermediate filament cytoskeleton.
dos
2017-12-20T13:45:35Z
molecular_function
GO:0099184
structural constituent of postsynaptic intermediate filament cytoskeleton
The action of a molecule that contributes to the structural integrity of a postsynaptic intermediate filament cytoskeleton.
GOC:dos
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprised of intermediate filament and their associated proteins in the postsynaptic cytoskeleton.
dos
2017-12-20T13:47:30Z
biological_process
GO:0099185
postsynaptic intermediate filament cytoskeleton organization
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprised of intermediate filament and their associated proteins in the postsynaptic cytoskeleton.
GOC:dos
The action of a molecule that contributes to the structural integrity of a postsynapse.
dos
2017-12-20T14:54:33Z
molecular_function
GO:0099186
structural constituent of postsynapse
The action of a molecule that contributes to the structural integrity of a postsynapse.
GOC:dos
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising cytoskeletal filaments and their associated proteins in the postsynaptic cytoskeleton.
dos
2017-12-20T15:06:57Z
biological_process
GO:0099188
postsynaptic cytoskeleton organization
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising cytoskeletal filaments and their associated proteins in the postsynaptic cytoskeleton.
GOC:dos
The portion of the spectrin-associated cytoskeleton contained within the postsynapse.
dos
2017-12-20T15:29:09Z
cellular_component
GO:0099189
postsynaptic spectrin-associated cytoskeleton
The portion of the spectrin-associated cytoskeleton contained within the postsynapse.
GOC:dos
PMID:28576936
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of spectrin-associated cytoskeleton and associated proteins in the postsynapse.
dos
2017-12-20T15:34:26Z
biological_process
GO:0099190
postsynaptic spectrin-associated cytoskeleton organization
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of spectrin-associated cytoskeleton and associated proteins in the postsynapse.
GOC:dos
PMID:28576936
Cell-cell signaling between presynapse and postsynapse mediated by brain-derived neurotrophic factor (BDNF) crossing the synaptic cleft.
dos
2017-12-20T15:48:33Z
trans-synaptic signaling by brain-derived neurotrophic factor
biological_process
GO:0099191
trans-synaptic signaling by BDNF
Cell-cell signaling between presynapse and postsynapse mediated by brain-derived neurotrophic factor (BDNF) crossing the synaptic cleft.
GOC:dos
A synapse formed by a cerebellar Golgi cell synapsing on to a cerebellar granule cell.
dos
2017-12-20T16:12:25Z
cellular_component
GO:0099192
cerebellar Golgi cell to granule cell synapse
A synapse formed by a cerebellar Golgi cell synapsing on to a cerebellar granule cell.
PMID:26134650
The component of the synaptic membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
dos
2017-05-25T17:24:23Z
cellular_component
GO:0099243
extrinsic component of synaptic membrane
The component of the synaptic membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
GOC:dos
The regulatory process by which increased cytosolic calcium levels lead to the the fusion of synaptic vesicles with the presynaptic active zone membrane by bringing primed synaptic vesicle membrane into contact with membrane presynaptic active zone membrane.
biological_process
GO:0099502
calcium-dependent activation of synaptic vesicle fusion
The regulatory process by which increased cytosolic calcium levels lead to the the fusion of synaptic vesicles with the presynaptic active zone membrane by bringing primed synaptic vesicle membrane into contact with membrane presynaptic active zone membrane.
PMID:23060190
A biological process in which synaptic vesicles are loaded with neurotransmitters, move to the active zone, exocytose and are then recycled via endocytosis, ultimately leading to reloading with neurotransmitters.
biological_process
GO:0099504
synaptic vesicle cycle
A biological process in which synaptic vesicles are loaded with neurotransmitters, move to the active zone, exocytose and are then recycled via endocytosis, ultimately leading to reloading with neurotransmitters.
GOC:aruk
GOC:bc
PMID:15217342
Any process that modulates the potential difference across a presynaptic membrane.
regulation of pre-synaptic membrane potential
biological_process
GO:0099505
regulation of presynaptic membrane potential
Any process that modulates the potential difference across a presynaptic membrane.
GOC:dph
GOC:ef
The directed movement of synaptic vesicles along actin filaments within a cell, powered by molecular motors.
biological_process
GO:0099506
synaptic vesicle transport along actin filament
The directed movement of synaptic vesicles along actin filaments within a cell, powered by molecular motors.
GOC:dos
Any ligand-gated ion channel activity, occurring in the presynaptic membrane, that is involved in regulation of presynaptic membrane potential.
ligand-gated ion channel activity involved in regulation of presynaptic membrane potential
ligand gated ion channel activity involved in regulation of presynaptic membrane potential
ligand-dependent ion channel activity involved in regulation of pre-synaptic membrane potential
ligand-dependent ion channel activity involved in regulation of presynaptic membrane potential
ligand-gated ion channel activity involved in regulation of pre-synaptic membrane potential
molecular_function
GO:0099507
ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
Any ligand-gated ion channel activity, occurring in the presynaptic membrane, that is involved in regulation of presynaptic membrane potential.
GOC:dos
PMID:15145529
PMID:19558451
Voltage-gated ion channel activity, occurring in the presynaptic membrane, involved in regulation of presynaptic membrane potential. This is a key step in synaptic transmission, following the arrival of an action potential at the synapse.
https://github.com/geneontology/go-ontology/issues/24479
voltage-gated ion channel activity involved in regulation of presynaptic membrane potential
voltage gated ion channel activity involved in regulation of presynaptic membrane potential
voltage-dependent ion channel activity involved in regulation of pre-synaptic membrane potential
voltage-dependent ion channel activity involved in regulation of presynaptic membrane potential
voltage-gated ion channel activity involved in regulation of pre-synaptic membrane potential
molecular_function
GO:0099508
voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
Voltage-gated ion channel activity, occurring in the presynaptic membrane, involved in regulation of presynaptic membrane potential. This is a key step in synaptic transmission, following the arrival of an action potential at the synapse.
GOC:dos
Any process that regulates the concentration of calcium in the presynaptic cytosol.
regulation of presynaptic cytosolic calcium levels
biological_process
GO:0099509
regulation of presynaptic cytosolic calcium ion concentration
Any process that regulates the concentration of calcium in the presynaptic cytosol.
GOC:dos
regulation of presynaptic cytosolic calcium levels
Regulation of cytosolic calcium ion concentrations via the directed movement of calcium ions across the plasma-membrane into the cytosol via the action of a voltage-gated calcium ion channel.
molecular_function
GO:0099511
voltage-gated calcium channel activity involved in regulation of cytosolic calcium levels
Regulation of cytosolic calcium ion concentrations via the directed movement of calcium ions across the plasma-membrane into the cytosol via the action of a voltage-gated calcium ion channel.
GOC:dos
The directed movement of synaptic vesicles along cytoskeletal fibers such as microfilaments or microtubules within a cell, powered by molecular motors.
biological_process
GO:0099514
synaptic vesicle cytoskeletal transport
The directed movement of synaptic vesicles along cytoskeletal fibers such as microfilaments or microtubules within a cell, powered by molecular motors.
GOC:dos
The directed movement of synaptic vesicles along microtubules within a cell, powered by molecular motors.
biological_process
GO:0099517
synaptic vesicle transport along microtubule
The directed movement of synaptic vesicles along microtubules within a cell, powered by molecular motors.
GOC:dos
Any ion antiporter activity, occurring in the presynaptic membrane, that is involved in regulation of presynaptic membrane potential.
https://github.com/geneontology/go-ontology/issues/24479
ion antiporter activity involved in regulation of pre-synaptic membrane potential
ion antiporter activity involved in regulation of presynaptic membrane potential
molecular_function
GO:0099520
monoatomic ion antiporter activity involved in regulation of presynaptic membrane potential
Any ion antiporter activity, occurring in the presynaptic membrane, that is involved in regulation of presynaptic membrane potential.
GOC:dos
Any ATPase coupled ion transmembrane transporter activity, occurring in the presynaptic membrane, that is involved in regulation of presynaptic membrane potential.
ATPase coupled ion transmembrane transporter activity involved in regulation of pre-synaptic membrane potential
ATPase-coupled ion transmembrane transporter activity involved in regulation of presynaptic membrane potential
molecular_function
GO:0099521
ATPase coupled ion transmembrane transporter activity involved in regulation of presynaptic membrane potential
Any ATPase coupled ion transmembrane transporter activity, occurring in the presynaptic membrane, that is involved in regulation of presynaptic membrane potential.
GOC:dos
PMID:17220883
The region of the cytosol consisting of all cytosol that is part of the presynapse.
cellular_component
GO:0099523
presynaptic cytosol
The region of the cytosol consisting of all cytosol that is part of the presynapse.
GOC:dos
The region of the cytosol consisting of all cytosol that is part of the postsynapse.
cellular_component
GO:0099524
postsynaptic cytosol
The region of the cytosol consisting of all cytosol that is part of the postsynapse.
GOC:dos
The secretion of molecules (e.g. neuropeptides and neuromodulators such as serotonin and dopamine) contained within a membrane-bounced dense in response to increased presynaptic cytosolic calcium levels.
biological_process
GO:0099525
presynaptic dense core vesicle exocytosis
The secretion of molecules (e.g. neuropeptides and neuromodulators such as serotonin and dopamine) contained within a membrane-bounced dense in response to increased presynaptic cytosolic calcium levels.
PMID:17553987
PMID:24653208
The series of molecular signals that conveys information from the presynapse to the nucleus via cytoskeletal transport of a protein from a presynapse to the component to the nucleus where it affects biochemical processes that occur in the nucleus (e.g DNA transcription, mRNA splicing, or DNA/histone modifications).
presynaptic signaling to nucleus
biological_process
GO:0099526
This class does not cover the cellular machinery (motor proteins, cargo-recognition proteins) that transports the signaling protein along the cytoskeleton towards the nucleus. For these cases, annotate to the appropriate transport/trafficking term.
presynapse to nucleus signaling pathway
The series of molecular signals that conveys information from the presynapse to the nucleus via cytoskeletal transport of a protein from a presynapse to the component to the nucleus where it affects biochemical processes that occur in the nucleus (e.g DNA transcription, mRNA splicing, or DNA/histone modifications).
GOC:dos
PMID:24317321
PMID:25652077
The series of molecular signals that conveys information from the postsynapse to the nucleus via cytoskeletal transport of a protein from a postsynapse to the component to the nucleus where it affects biochemical processes that occur in the nucleus (e.g DNA transcription, mRNA splicing, or DNA/histone modifications).
postsynaptic signaling to nucleus
biological_process
GO:0099527
postsynapse to nucleus signaling pathway
The series of molecular signals that conveys information from the postsynapse to the nucleus via cytoskeletal transport of a protein from a postsynapse to the component to the nucleus where it affects biochemical processes that occur in the nucleus (e.g DNA transcription, mRNA splicing, or DNA/histone modifications).
GOC:dos
PMID:24317321
PMID:25652077
Neurotransmitter receptor activity occurring in the postsynaptic membrane that is involved in regulating postsynaptic membrane potential, either directly (ionotropic receptors) or indirectly (e.g. via GPCR activation of an ion channel).
molecular_function
GO:0099529
neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential
Neurotransmitter receptor activity occurring in the postsynaptic membrane that is involved in regulating postsynaptic membrane potential, either directly (ionotropic receptors) or indirectly (e.g. via GPCR activation of an ion channel).
GOC:dos
A G protein-coupled receptor activity occurring in the postsynaptic membrane that is part of a GPCR signaling pathway that positively regulates ion channel activity in the postsynaptic membrane.
G-protein coupled receptor activity involved in regulation of postsynaptic membrane potential
molecular_function
GO:0099530
G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential
A G protein-coupled receptor activity occurring in the postsynaptic membrane that is part of a GPCR signaling pathway that positively regulates ion channel activity in the postsynaptic membrane.
GOC:dos
The pathway leading to secretion of a neurotransmitter from the presynapse as part of synaptic transmission.
biological_process
GO:0099531
presynaptic process involved in chemical synaptic transmission
The pathway leading to secretion of a neurotransmitter from the presynapse as part of synaptic transmission.
GOC:dos
The process in which synaptic vesicles fuse to the presynaptic endosome followed by sorting of synaptic vesicle components and budding of new synaptic vesicles.
synaptic vesicle processing via endosome
biological_process
GO:0099532
This covers processing of synaptic vesicles trafficked to synapse as well as of endocytosed vesicles as part of recycling. It is there for not part of the synaptic vesicle cycle.
synaptic vesicle endosomal processing
The process in which synaptic vesicles fuse to the presynaptic endosome followed by sorting of synaptic vesicle components and budding of new synaptic vesicles.
GOC:aruk
GOC:bc
GOC:dos
Any process that increases the concentration of calcium ions in the presynaptic cytosol.
biological_process
GO:0099533
positive regulation of presynaptic cytosolic calcium concentration
Any process that increases the concentration of calcium ions in the presynaptic cytosol.
GOC:dos
The directed change of presynaptic cytosolic free calcium ion concentration in the cytosol via the reversible binding of calcium ions to calcium-binding proteins in the cytosol thereby modulating the spatial and temporal dynamics of changes in presynaptic cytosolic calcium concentrations.
calcium ion binding involved in regulation of presynaptic cytosolic calcium levels
presynaptic calcium ion buffering
regulation of presynaptic cytosolic calcium ion concentration by calcium ion buffering
molecular_function
GO:0099534
calcium ion binding involved in regulation of presynaptic cytosolic calcium ion concentration
The directed change of presynaptic cytosolic free calcium ion concentration in the cytosol via the reversible binding of calcium ions to calcium-binding proteins in the cytosol thereby modulating the spatial and temporal dynamics of changes in presynaptic cytosolic calcium concentrations.
PMID:24442513
PMID:26190970
calcium ion binding involved in regulation of presynaptic cytosolic calcium levels
The extracellular matrix of the perisynaptic space (the extracellular space adjacent to the synapse) and the synaptic cleft.
extra-synaptic extracellular matrix
cellular_component
GO:0099535
synapse-associated extracellular matrix
The extracellular matrix of the perisynaptic space (the extracellular space adjacent to the synapse) and the synaptic cleft.
GOC:dos
Cell-cell signaling to, from or within a synapse.
biological_process
GO:0099536
synaptic signaling
Cell-cell signaling to, from or within a synapse.
GOC:dos
Cell-cell signaling in either direction across the synaptic cleft.
biological_process
GO:0099537
trans-synaptic signaling
Cell-cell signaling in either direction across the synaptic cleft.
GOC:dos
Cell-cell signaling to or from a synapse, mediated by a peptide.
biological_process
GO:0099538
synaptic signaling via neuropeptide
Cell-cell signaling to or from a synapse, mediated by a peptide.
GOC:dos
The secretion of neuropeptides contained within a dense core vesicle by fusion of the granule with the presynaptic membrane, stimulated by a rise in cytosolic calcium ion concentration.
neuropeptide secretion from presynapse via dense core granule exocytosis
biological_process
GO:0099539
neuropeptide secretion from presynapse
The secretion of neuropeptides contained within a dense core vesicle by fusion of the granule with the presynaptic membrane, stimulated by a rise in cytosolic calcium ion concentration.
PMID:17553987
PMID:24653208
Cell-cell signaling between presynapse and postsynapse mediated by a peptide ligand crossing the synaptic cleft.
biological_process
GO:0099540
trans-synaptic signaling by neuropeptide
Cell-cell signaling between presynapse and postsynapse mediated by a peptide ligand crossing the synaptic cleft.
GOC:dos
Cell-cell signaling from post to pre-synapse, across the synaptic cleft, mediated by a lipid.
biological_process
GO:0099541
trans-synaptic signaling by lipid
Cell-cell signaling from post to pre-synapse, across the synaptic cleft, mediated by a lipid.
GOC:dos
Cell-cell signaling in either direction across the synaptic cleft, mediated by an endocannabinoid ligand.
biological_process
GO:0099542
trans-synaptic signaling by endocannabinoid
Cell-cell signaling in either direction across the synaptic cleft, mediated by an endocannabinoid ligand.
GOC:dos
Cell-cell signaling between presynapse and postsynapse mediated by a soluble gas ligand crossing the synaptic cleft.
biological_process
GO:0099543
trans-synaptic signaling by soluble gas
Cell-cell signaling between presynapse and postsynapse mediated by a soluble gas ligand crossing the synaptic cleft.
GOC:dos
The extracellular region immediately adjacent to to a synapse.
extrasynaptic space
cellular_component
GO:0099544
perisynaptic space
The extracellular region immediately adjacent to to a synapse.
GOC:dos
extrasynaptic space
Cell-cell signaling between presynapse and postsynapse mediated by a trans-synaptic protein complex.
biological_process
GO:0099545
trans-synaptic signaling by trans-synaptic complex
Cell-cell signaling between presynapse and postsynapse mediated by a trans-synaptic protein complex.
GOC:dos
Any protein degradation process, occurring at a presynapse, that regulates synaptic transmission.
biological_process
GO:0099546
Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
protein catabolic process, modulating synaptic transmission
Any protein degradation process, occurring at a presynapse, that regulates synaptic transmission.
GOC:dos
PMID:23083742
Any process that modulates synaptic transmission by regulating translation occurring at the synapse.
biological_process
GO:0099547
Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
regulation of translation at synapse, modulating synaptic transmission
Any process that modulates synaptic transmission by regulating translation occurring at the synapse.
GOC:dos
Cell-cell signaling between presynapse and postsynapse mediated by nitric oxide.
biological_process
GO:0099548
trans-synaptic signaling by nitric oxide
Cell-cell signaling between presynapse and postsynapse mediated by nitric oxide.
GOC:dos
Cell-cell signaling between presynapse and postsynapse mediated by carbon monoxide.
biological_process
GO:0099549
trans-synaptic signaling by carbon monoxide
Cell-cell signaling between presynapse and postsynapse mediated by carbon monoxide.
GOC:dos
Cell-cell signaling between presynapse and postsynapse, across the synaptic cleft, that modulates the synaptic transmission properties of the synapse.
biological_process
GO:0099550
Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
trans-synaptic signaling, modulating synaptic transmission
Cell-cell signaling between presynapse and postsynapse, across the synaptic cleft, that modulates the synaptic transmission properties of the synapse.
GOC:dos
Cell-cell signaling between presynapse and postsynapse, via the vesicular release and reception of neuropeptide molecules, that modulates the synaptic transmission properties of the synapse.
biological_process
GO:0099551
Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
trans-synaptic signaling by neuropeptide, modulating synaptic transmission
Cell-cell signaling between presynapse and postsynapse, via the vesicular release and reception of neuropeptide molecules, that modulates the synaptic transmission properties of the synapse.
GOC:dos
Cell-cell signaling between presynapse and postsynapse, via the release and reception of lipid molecules, that modulates the synaptic transmission properties of the synapse.
biological_process
GO:0099552
Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
trans-synaptic signaling by lipid, modulating synaptic transmission
Cell-cell signaling between presynapse and postsynapse, via the release and reception of lipid molecules, that modulates the synaptic transmission properties of the synapse.
GOC:dos
PMID:21531987
Cell-cell signaling between presynapse and postsynapse, via the release and reception of endocannabinoid ligands, that modulates the synaptic transmission properties of the synapse.
biological_process
GO:0099553
Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
trans-synaptic signaling by endocannabinoid, modulating synaptic transmission
Cell-cell signaling between presynapse and postsynapse, via the release and reception of endocannabinoid ligands, that modulates the synaptic transmission properties of the synapse.
GOC:dos
PMID:21531987
Cell-cell signaling between presynapse and postsynapse, via the release and reception of gaseous molecules, that modulates the synaptic transmission properties of the synapse.
biological_process
GO:0099554
Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
trans-synaptic signaling by soluble gas, modulating synaptic transmission
Cell-cell signaling between presynapse and postsynapse, via the release and reception of gaseous molecules, that modulates the synaptic transmission properties of the synapse.
GOC:dos
Cell-cell signaling between presynapse and postsynapse, via the release and reception of nitric oxide molecules, that modulates the synaptic transmission properties of the synapse.
biological_process
GO:0099555
Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
trans-synaptic signaling by nitric oxide, modulating synaptic transmission
Cell-cell signaling between presynapse and postsynapse, via the release and reception of nitric oxide molecules, that modulates the synaptic transmission properties of the synapse.
GOC:dos
Cell-cell signaling between presynapse and postsynapse, via the release and reception of carbon monoxide molecules, that modulates the synaptic transmission properties of the synapse.
biological_process
GO:0099556
Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
trans-synaptic signaling by carbon monoxide, modulating synaptic transmission
Cell-cell signaling between presynapse and postsynapse, via the release and reception of carbon monoxide molecules, that modulates the synaptic transmission properties of the synapse.
GOC:dos
Cell-cell signaling between presynapse and postsynapse, mediated by transynaptic protein complexes, that modulates the synaptic transmission properties of the synapse.
biological_process
GO:0099557
Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission
Cell-cell signaling between presynapse and postsynapse, mediated by transynaptic protein complexes, that modulates the synaptic transmission properties of the synapse.
GOC:dos
PMID:19029886
A process that preserves the structural organistation and orientation of a synaptic cellular component such as the synaptic cytoskeleton and molecular scaffolds.
synaptic maintenance
biological_process
GO:0099558
maintenance of synapse structure
A process that preserves the structural organistation and orientation of a synaptic cellular component such as the synaptic cytoskeleton and molecular scaffolds.
GOC:dos
PMID:24449494
PMID:25611509
The process by which alignment between postsynaptic density and presynaptic active zone is maintained.
biological_process
GO:0099559
maintenance of alignment of postsynaptic density and presynaptic active zone
The process by which alignment between postsynaptic density and presynaptic active zone is maintained.
GOC:dos
The attachment of presynaptic membrane to postsynaptic membrane via adhesion molecules that are at least partially embedded in the plasma membrane.
synapse adhesion between pre- and post-synapse
biological_process
GO:0099560
synaptic membrane adhesion
The attachment of presynaptic membrane to postsynaptic membrane via adhesion molecules that are at least partially embedded in the plasma membrane.
GOC:dos
synapse adhesion between pre- and post-synapse
The binding of a synaptic membrane to the extracellular matrix via adhesion molecules.
biological_process
GO:0099561
synaptic membrane adhesion to extracellular matrix
The binding of a synaptic membrane to the extracellular matrix via adhesion molecules.
GOC:dos
A process which maintains the organization and the arrangement of proteins in the presynaptic density.
biological_process
GO:0099562
maintenance of postsynaptic density structure
A process which maintains the organization and the arrangement of proteins in the presynaptic density.
GOC:dos
Any process that modifies the structure/morphology of a synapse.
synapse remodelling
biological_process
GO:0099563
This class does not cover assembly or disassembly of synapses, only the modification/remodelling of existing ones.
modification of synaptic structure
Any process that modifies the structure/morphology of a synapse.
GOC:dos
Any process that modulates synaptic transmission via modification of the structure of the synapse.
biological_process
GO:0099564
Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
modification of synaptic structure, modulating synaptic transmission
Any process that modulates synaptic transmission via modification of the structure of the synapse.
GOC:dos
The part of synaptic transmission occurring in the post-synapse: a signal transduction pathway consisting of neurotransmitter receptor activation and its effects on postsynaptic membrane potential and the ionic composition of the postsynaptic cytosol.
postsynaptic process involved in chemical synaptic transmission
biological_process
GO:0099565
chemical synaptic transmission, postsynaptic
The part of synaptic transmission occurring in the post-synapse: a signal transduction pathway consisting of neurotransmitter receptor activation and its effects on postsynaptic membrane potential and the ionic composition of the postsynaptic cytosol.
GOC:dos
postsynaptic process involved in chemical synaptic transmission
Any process that regulates the concentration of calcium in the postsynaptic cytosol.
regulation of postsynaptic cytosolic calcium levels
biological_process
GO:0099566
regulation of postsynaptic cytosolic calcium ion concentration
Any process that regulates the concentration of calcium in the postsynaptic cytosol.
GOC:dos
regulation of postsynaptic cytosolic calcium levels
The directed change of free calcium ion concentration in the postsynaptic cytosol via the reversible binding of calcium ions to calcium-binding proteins in the cytosol thereby modulating the spatial and temporal dynamics of changes in postsynaptic cytosolic calcium concentrations.
calcium ion binding involved in regulation of postsynaptic cytosolic calcium levels
postsynaptic calcium ion buffering
molecular_function
regulation of postsynaptic cytosolic calcium ion concentration by calcium ion buffering
GO:0099567
calcium ion binding involved in regulation of postsynaptic cytosolic calcium ion concentration
The directed change of free calcium ion concentration in the postsynaptic cytosol via the reversible binding of calcium ions to calcium-binding proteins in the cytosol thereby modulating the spatial and temporal dynamics of changes in postsynaptic cytosolic calcium concentrations.
PMID:24442513
PMID:26190970
calcium ion binding involved in regulation of postsynaptic cytosolic calcium levels
The portion of the cytoskeleton contained within the presynapse.
cellular_component
GO:0099569
presynaptic cytoskeleton
The portion of the cytoskeleton contained within the presynapse.
GOC:dos
The portion of the cytoskeleton contained within the postsynapse.
cellular_component
GO:0099571
postsynaptic cytoskeleton
The portion of the cytoskeleton contained within the postsynapse.
GOC:dos
PMID:19889835
A network of proteins within and adjacent to the postsynaptic membrane. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components.
cellular_component
GO:0099572
postsynaptic specialization
A network of proteins within and adjacent to the postsynaptic membrane. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components.
PMID:22046028
The post-synaptic specialization of a glutamatergic excitatory synapse.
postsynaptic specialization, glutamatergic neuron-to-neuron synapse
cellular_component
GO:0099573
glutamatergic postsynaptic density
The post-synaptic specialization of a glutamatergic excitatory synapse.
GOC:dos
postsynaptic specialization, glutamatergic neuron-to-neuron synapse
Any process that modulates synaptic transmission by regulating protein degradation at the synapse.
biological_process
GO:0099574
Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
regulation of protein catabolic process at synapse, modulating synaptic transmission
Any process that modulates synaptic transmission by regulating protein degradation at the synapse.
GOC:dos
Any process that modulates synaptic transmission by regulating a catabolic process occurring at a presynapse.
biological_process
GO:0099575
Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
regulation of protein catabolic process at presynapse, modulating synaptic transmission
Any process that modulates synaptic transmission by regulating a catabolic process occurring at a presynapse.
GOC:dos
Any process that modulates synaptic transmission by regulating a catabolic process occurring at a postsynapse.
biological_process
GO:0099576
Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
regulation of protein catabolic process at postsynapse, modulating synaptic transmission
Any process that modulates synaptic transmission by regulating a catabolic process occurring at a postsynapse.
GOC:dos
Any process that modulates synaptic transmission by regulating translation occurring at the presynapse.
biological_process
GO:0099577
Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
regulation of translation at presynapse, modulating synaptic transmission
Any process that modulates synaptic transmission by regulating translation occurring at the presynapse.
GOC:dos
Any process that modulates synaptic transmission by regulating translation occurring at the postsynapse.
biological_process
GO:0099578
Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
regulation of translation at postsynapse, modulating synaptic transmission
Any process that modulates synaptic transmission by regulating translation occurring at the postsynapse.
GOC:dos
A G protein-coupled neurotransmitter receptor activity, occurring in the postsynaptic membrane, involved in regulation of postsynaptic membrane potential.
G-protein coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential
molecular_function
GO:0099579
G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential
A G protein-coupled neurotransmitter receptor activity, occurring in the postsynaptic membrane, involved in regulation of postsynaptic membrane potential.
GOC:dos
Any ion antiporter activity, occurring in the postsynaptic membrane, that is involved in regulation of postsynaptic membrane potential.
https://github.com/geneontology/go-ontology/issues/24479
ion antiporter activity involved in regulation of post-synaptic membrane potential
ion antiporter activity involved in regulation of postsynaptic membrane potential
molecular_function
GO:0099580
monoatomic ion antiporter activity involved in regulation of postsynaptic membrane potential
Any ion antiporter activity, occurring in the postsynaptic membrane, that is involved in regulation of postsynaptic membrane potential.
GOC:dos
Any ATPase coupled ion transmembrane transporter activity, occurring in the postsynaptic membrane, that is involved in regulation of postsynaptic membrane potential.
ATPase coupled ion transmembrane transporter activity involved in regulation of post-synaptic membrane potential
ATPase-coupled ion transmembrane transporter activity involved in regulation of postsynaptic membrane potential
molecular_function
GO:0099581
ATPase coupled ion transmembrane transporter activity involved in regulation of postsynaptic membrane potential
Any ATPase coupled ion transmembrane transporter activity, occurring in the postsynaptic membrane, that is involved in regulation of postsynaptic membrane potential.
GOC:dos
Any neurotransmitter receptor activity that is involved in regulating the concentration of calcium in the presynaptic cytosol.
neurotransmitter receptor activity involved in regulation of presynaptic cytosolic calcium levels
molecular_function
GO:0099582
neurotransmitter receptor activity involved in regulation of presynaptic cytosolic calcium ion concentration
Any neurotransmitter receptor activity that is involved in regulating the concentration of calcium in the presynaptic cytosol.
GOC:dos
neurotransmitter receptor activity involved in regulation of presynaptic cytosolic calcium levels
Any neurotransmitter receptor activity that is involved in regulating the concentration of calcium in the postsynaptic cytosol.
neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium levels
molecular_function
GO:0099583
neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration
Any neurotransmitter receptor activity that is involved in regulating the concentration of calcium in the postsynaptic cytosol.
GOC:dos
neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium levels
The process in which calcium ions sequestered in the endoplasmic reticulum, Golgi apparatus or mitochondria are released into the presynaptic cytosol.
biological_process
GO:0099585
release of sequestered calcium ion into presynaptic cytosol
The process in which calcium ions sequestered in the endoplasmic reticulum, Golgi apparatus or mitochondria are released into the presynaptic cytosol.
GOC:dos
The process in which calcium ions sequestered in the endoplasmic reticulum, Golgi apparatus or mitochondria are released into the postsynaptic cytosol.
biological_process
GO:0099586
release of sequestered calcium ion into postsynaptic cytosol
The process in which calcium ions sequestered in the endoplasmic reticulum, Golgi apparatus or mitochondria are released into the postsynaptic cytosol.
GOC:dos
Any process that increases the concentration of calcium ions in the postsynaptic cytosol.
biological_process
GO:0099588
positive regulation of postsynaptic cytosolic calcium concentration
Any process that increases the concentration of calcium ions in the postsynaptic cytosol.
GOC:dos
Any process that modulates the frequency, rate or extent of neurotransmitter receptor activity. Modulation may be via an effect on ligand affinity, or effector funtion such as ion selectivity or pore opening/closing in ionotropic receptors.
biological_process
GO:0099601
regulation of neurotransmitter receptor activity
Any process that modulates the frequency, rate or extent of neurotransmitter receptor activity. Modulation may be via an effect on ligand affinity, or effector funtion such as ion selectivity or pore opening/closing in ionotropic receptors.
GOC:dos
Regulation of presynaptic cytosolic calcium ion concentrations via the action of voltage-gated calcium ion channels.
voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels
molecular_function
GO:0099626
voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels
Regulation of presynaptic cytosolic calcium ion concentrations via the action of voltage-gated calcium ion channels.
GOC:dos
PMID:15548655
voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels
The process by which diffusing neurotransmitter receptor becomes trapped in region of the plasma membrane.
biological_process
GO:0099628
neurotransmitter receptor diffusion trapping
The process by which diffusing neurotransmitter receptor becomes trapped in region of the plasma membrane.
PMID:18832033
A network of proteins within and adjacent to the postsynaptic membrane of a symmetric synapse, consisting of anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components that spatially and functionally organize the neurotransmitter receptors at the synapse. This structure is not as thick or electron dense as the postsynaptic densities found in asymmetric synapses.
postsynaptic density of inhibitory synapse
cellular_component
GO:0099629
postsynaptic specialization of symmetric synapse
A network of proteins within and adjacent to the postsynaptic membrane of a symmetric synapse, consisting of anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components that spatially and functionally organize the neurotransmitter receptors at the synapse. This structure is not as thick or electron dense as the postsynaptic densities found in asymmetric synapses.
PMID:18832033
postsynaptic density of inhibitory synapse
PMID:18832033
The cytoplasmic component of the postsynaptic endocytic zone.
cellular_component
GO:0099631
postsynaptic endocytic zone cytoplasmic component
The cytoplasmic component of the postsynaptic endocytic zone.
GOC:dos
The membrane component of the postsynaptic specialization. This is the region of the postsynaptic membrane in which the population of neurotransmitter receptors involved in synaptic transmission are concentrated.
cellular_component
GO:0099634
postsynaptic specialization membrane
The membrane component of the postsynaptic specialization. This is the region of the postsynaptic membrane in which the population of neurotransmitter receptors involved in synaptic transmission are concentrated.
GOC:dos
Positive regulation of presynaptic cytosolic calcium ion concentrations via the directed movement of calcium ions across the plasma-membrane into the cytosol via the action of voltage-gated calcium ion channels. This is the first step in synaptic transmission.
Reactome:R-HSA-9659515
molecular_function
GO:0099635
voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels
Positive regulation of presynaptic cytosolic calcium ion concentrations via the directed movement of calcium ions across the plasma-membrane into the cytosol via the action of voltage-gated calcium ion channels. This is the first step in synaptic transmission.
GOC:dos
Reactome:R-HSA-9659515
CACNA1D:CACNA2D2:CACNB2 (Cav1.3 channel) transports Ca2+ into the cytosol of an inner hair cell
The directed movement of neurotransmitter receptors.
biological_process
GO:0099637
neurotransmitter receptor transport
The directed movement of neurotransmitter receptors.
GOC:dos
The directed movement of neurotransmitter receptor from the endosome to the plasma membrane in transport vesicles.
biological_process
GO:0099639
neurotransmitter receptor transport, endosome to plasma membrane
The directed movement of neurotransmitter receptor from the endosome to the plasma membrane in transport vesicles.
GOC:dos
The directed movement of proteins along microtubules in neuron projections.
axonal protein transport
biological_process
GO:0099640
axo-dendritic protein transport
The directed movement of proteins along microtubules in neuron projections.
ISBN:0815316194
The directed movement of proteins along microtubules from the cell body toward the cell periphery in nerve cell axons.
anterograde axon cargo transport
biological_process
GO:0099641
anterograde axonal protein transport
The directed movement of proteins along microtubules from the cell body toward the cell periphery in nerve cell axons.
GOC:dos
The directed movement of proteins along microtubules from the cell periphery toward the cell body in nerve cell axons.
retrograde axon cargo transport
biological_process
GO:0099642
retrograde axonal protein transport
The directed movement of proteins along microtubules from the cell periphery toward the cell body in nerve cell axons.
ISBN:0815316194
Any signal release from a synapse.
biological_process
GO:0099643
signal release from synapse
Any signal release from a synapse.
GOC:dos
A process in which a neurotransmitter is transported to, or maintained in, a location within the membrane adjacent to a postsynaptic specialization (e.g. postsynaptic density).
neurotransmitter receptor localisation in postsynaptic specialization membrane
biological_process
GO:0099645
neurotransmitter receptor localization to postsynaptic specialization membrane
A process in which a neurotransmitter is transported to, or maintained in, a location within the membrane adjacent to a postsynaptic specialization (e.g. postsynaptic density).
GOC:dos
neurotransmitter receptor localisation in postsynaptic specialization membrane
GOC:TermGenie
Vesicle-mediated transport of a neurotransmitter receptor vesicle from the plasma membrane to the endosome.
biological_process
GO:0099646
neurotransmitter receptor transport, plasma membrane to endosome
Vesicle-mediated transport of a neurotransmitter receptor vesicle from the plasma membrane to the endosome.
GOC:dos
The induction of synaptic vesicle release by any process that leads to a rise in intracellular calcium ion concentration at the presynapse. This is the first step in synaptic transmission.
biological_process
GO:0099703
induction of synaptic vesicle exocytosis by positive regulation of presynaptic cytosolic calcium ion concentration
The induction of synaptic vesicle release by any process that leads to a rise in intracellular calcium ion concentration at the presynapse. This is the first step in synaptic transmission.
GOC:dos
ISBN:9780071120005
The directed movement of a neurotransmitter receptor complex along microtubules from the cell body toward the cell periphery in nerve cell axons.
pg
2018-07-09T09:41:37Z
biological_process
GO:0140231
anterograde axonal transport of neurotransmitter receptor complex
The directed movement of a neurotransmitter receptor complex along microtubules from the cell body toward the cell periphery in nerve cell axons.
PMID:28680963
Enables the transmembrane transfer of a cation by a channel that opens when intracellular cAMP has been bound by the channel complex or one of its constituent parts, to regulate the presynaptic membrane potential.
https://github.com/geneontology/synapse/issues/231
pg
2018-07-09T11:30:40Z
intracellular cAMP activated cation channel activity involved in regulation of presynaptic membrane potential
molecular_function
GO:0140232
Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
intracellular cAMP-activated cation channel activity involved in regulation of presynaptic membrane potential
Enables the transmembrane transfer of a cation by a channel that opens when intracellular cAMP has been bound by the channel complex or one of its constituent parts, to regulate the presynaptic membrane potential.
PMID:21358644
Enables the transmembrane transfer of a cation by a channel that opens when intracellular cAMP has been bound by the channel complex or one of its constituent parts, to regulate the postsynaptic membrane potential.
https://github.com/geneontology/synapse/issues/231
pg
2018-07-09T11:31:18Z
intracellular cAMP activated cation channel activity involved in regulation of postsynaptic membrane potential
molecular_function
GO:0140233
Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
intracellular cAMP-activated cation channel activity involved in regulation of postsynaptic membrane potential
Enables the transmembrane transfer of a cation by a channel that opens when intracellular cAMP has been bound by the channel complex or one of its constituent parts, to regulate the postsynaptic membrane potential.
GOC:pvn
A polyadenylation event (the enzymatic addition of a sequence of adenylyl residues at the 3' end of an RNA molecule) that takes place at a postsynapse.
pg
2018-07-13T12:03:28Z
biological_process
GO:0140235
Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
RNA polyadenylation at postsynapse
A polyadenylation event (the enzymatic addition of a sequence of adenylyl residues at the 3' end of an RNA molecule) that takes place at a postsynapse.
PMID:22727665
Translation that occurs at the presynapse.
https://github.com/geneontology/synapse/issues/216
pg
2018-07-13T13:00:33Z
biological_process
GO:0140236
Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
translation at presynapse
Translation that occurs at the presynapse.
PMID:27321671
Translation that occurs at the presynapse, and that modulates chemical synaptic transmission.
https://github.com/geneontology/synapse/issues/216
pg
2018-07-13T13:07:23Z
biological_process
GO:0140237
Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
translation at presynapse, modulating chemical synaptic transmission
Translation that occurs at the presynapse, and that modulates chemical synaptic transmission.
PMID:27321671
A vesicle-mediated transport process in which the presynapse take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle.
https://github.com/geneontology/synapse/issues/230
pg
2018-07-15T07:33:55Z
biological_process
GO:0140238
Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
presynaptic endocytosis
A vesicle-mediated transport process in which the presynapse take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle.
PMID:24719103
A vesicle-mediated transport process in which the postsynapse take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle.
https://github.com/geneontology/synapse/issues/230
pg
2018-07-15T07:38:27Z
biological_process
GO:0140239
Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
postsynaptic endocytosis
A vesicle-mediated transport process in which the postsynapse take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle.
PMID:12839988
A neuron to neuron synapse of a pyramidal neuron in the entorhinal cortex onto a granule cell in the dentate gyrus of the hippocampus.
https://github.com/geneontology/synapse/issues/234
pg
2018-07-15T08:21:43Z
perforant pathway to DG granule cell synapse
cellular_component
GO:0140240
perforant pathway to dendrate granule cell synapse
A neuron to neuron synapse of a pyramidal neuron in the entorhinal cortex onto a granule cell in the dentate gyrus of the hippocampus.
PMID:22727665
PMID:29199135
Translation that occurs at the synapse.
https://github.com/geneontology/synapse/issues/210
pg
2018-07-15T09:23:12Z
biological_process
GO:0140241
Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
translation at synapse
Translation that occurs at the synapse.
PMID:23083742
Translation that occurs at the postsynapse.
https://github.com/geneontology/synapse/issues/210
pg
2018-07-15T09:26:27Z
biological_process
GO:0140242
Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
translation at postsynapse
Translation that occurs at the postsynapse.
PMID:20427644
Any process that regulates translation occurring at the synapse.
https://github.com/geneontology/synapse/issues/210
pg
2018-07-15T09:38:26Z
biological_process
GO:0140243
Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
regulation of translation at synapse
Any process that regulates translation occurring at the synapse.
PMID:20427644
Any process that regulates translation occurring at the presynapse.
https://github.com/geneontology/synapse/issues/210
pg
2018-07-15T09:38:33Z
biological_process
GO:0140244
Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
regulation of translation at presynapse
Any process that regulates translation occurring at the presynapse.
PMID:20427644
Any process that regulates translation occurring at the postsynapse.
https://github.com/geneontology/synapse/issues/210
pg
2018-07-15T09:38:54Z
biological_process
GO:0140245
Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
regulation of translation at postsynapse
Any process that regulates translation occurring at the postsynapse.
PMID:20427644
The chemical reactions and pathways resulting in the breakdown of a protein at a synapse.
https://github.com/geneontology/synapse/issues/210
pg
2018-07-15T10:12:51Z
biological_process
GO:0140246
Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
protein catabolic process at synapse
The chemical reactions and pathways resulting in the breakdown of a protein at a synapse.
PMID:17062563
The chemical reactions and pathways resulting in the breakdown of a protein at a presynapse.
https://github.com/geneontology/synapse/issues/204
pg
2018-07-15T10:23:49Z
biological_process
GO:0140247
Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
protein catabolic process at presynapse
The chemical reactions and pathways resulting in the breakdown of a protein at a presynapse.
PMID:27764673
The chemical reactions and pathways resulting in the breakdown of a protein at a postsynapse.
https://github.com/geneontology/synapse/issues/204
pg
2018-07-15T10:25:04Z
biological_process
GO:0140249
Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
protein catabolic process at postsynapse
The chemical reactions and pathways resulting in the breakdown of a protein at a postsynapse.
PMID:17062563
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein at the synapse.
https://github.com/geneontology/synapse/issues/204
pg
2018-07-15T10:34:56Z
biological_process
GO:0140250
Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
regulation protein catabolic process at synapse
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein at the synapse.
PMID:23083742
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein at the presynapse.
https://github.com/geneontology/synapse/issues/204
pg
2018-07-15T10:35:39Z
biological_process
GO:0140251
Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
regulation protein catabolic process at presynapse
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein at the presynapse.
PMID:27764673
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein at the postsynapse.
https://github.com/geneontology/synapse/issues/204
pg
2018-07-15T10:35:56Z
biological_process
GO:0140252
Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
regulation protein catabolic process at postsynapse
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein at the postsynapse.
PMID:17062563
Any process that modulates the frequency, rate or extent of trans-synaptic signaling by BDNF, modulating synaptic transmission.
bc
2018-04-17T13:56:34Z
biological_process
GO:0150035
Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
regulation of trans-synaptic signaling by BDNF, modulating synaptic transmission
Any process that modulates the frequency, rate or extent of trans-synaptic signaling by BDNF, modulating synaptic transmission.
GOC:aruk
GOC:bc
PMID:19448629
Any process that modulates the frequency, rate or extent of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission.
bc
2018-04-18T09:54:49Z
biological_process
GO:0150036
Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
regulation of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission
Any process that modulates the frequency, rate or extent of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission.
GOC:aruk
GOC:bc
PMID:27296803
Any process that modulates the frequency, rate or extent of calcium-dependent activation of synaptic vesicle fusion.
bc
2018-04-18T12:47:38Z
biological_process
GO:0150037
regulation of calcium-dependent activation of synaptic vesicle fusion
Any process that modulates the frequency, rate or extent of calcium-dependent activation of synaptic vesicle fusion.
GOC:aruk
GOC:bc
PMID:27052163
The secretion of molecules (e.g. neuropeptides, insulin-related peptides or neuromodulators such as serotonin and dopamine) contained within a postsynaptic dense core vesicle by fusion of the granule with the plasma membrane of the postsynapse in response to increased cytosolic calcium levels.
bc
2018-04-18T14:32:16Z
biological_process
GO:0150038
postsynaptic dense core vesicle exocytosis
The secretion of molecules (e.g. neuropeptides, insulin-related peptides or neuromodulators such as serotonin and dopamine) contained within a postsynaptic dense core vesicle by fusion of the granule with the plasma membrane of the postsynapse in response to increased cytosolic calcium levels.
GOC:aruk
GOC:bc
PMID:19448629
The action of a molecule that contributes to the structural integrity of the extracellular matrix of the perisynaptic space (the extracellular space adjacent to the synapse) and the synaptic cleft.
bc
2018-04-19T13:42:40Z
extra-synaptic extracellular matrix structural constituent
structural constituent of extra-synaptic extracellular matrix
synapse-associated extracellular matrix structural constituent
molecular_function
GO:0150043
structural constituent of synapse-associated extracellular matrix
The action of a molecule that contributes to the structural integrity of the extracellular matrix of the perisynaptic space (the extracellular space adjacent to the synapse) and the synaptic cleft.
GOC:aruk
GOC:bc
PMID:17189701
Any process that modulates the frequency, rate or extent of postsynaptic dense core vesicle exocytosis.
bc
2018-04-20T13:34:32Z
biological_process
GO:0150044
regulation of postsynaptic dense core vesicle exocytosis
Any process that modulates the frequency, rate or extent of postsynaptic dense core vesicle exocytosis.
GOC:aruk
GOC:bc
PMID:19448629
Any process that modulates the frequency, rate or extent of synaptic signaling by nitric oxide.
bc
2018-04-23T09:42:25Z
biological_process
GO:0150045
regulation of synaptic signaling by nitric oxide
Any process that modulates the frequency, rate or extent of synaptic signaling by nitric oxide.
GOC:aruk
GOC:bc
PMID:26311509
G protein-coupled neurotransmitter receptor activity, occurring in the presynaptic membrane, involved in regulation of presynaptic membrane potential.
bc
2018-04-23T10:51:20Z
G-protein coupled neurotransmitter receptor activity involved in regulation of presynaptic membrane potential
molecular_function
GO:0150047
G protein-coupled neurotransmitter receptor activity involved in regulation of presynaptic membrane potential
G protein-coupled neurotransmitter receptor activity, occurring in the presynaptic membrane, involved in regulation of presynaptic membrane potential.
GOC:aruk
GOC:bc
PMID:11498050
A synapse of a granule cell fiber onto the dendrites of a Purkinje cell in cerebellum.
bc
2018-04-23T14:44:40Z
cerebellar parallel fiber to Purkinje cell synapse
cellular_component
GO:0150048
cerebellar granule cell to Purkinje cell synapse
A synapse of a granule cell fiber onto the dendrites of a Purkinje cell in cerebellum.
GOC:aruk
GOC:bc
PMID:12427822
The portion of the septin cytoskeleton contained within the postsynapse.
bc
2018-04-26T14:45:52Z
cellular_component
GO:0150050
postsynaptic septin cytoskeleton
The portion of the septin cytoskeleton contained within the postsynapse.
GOC:aruk
GOC:bc
PMID:28065648
The network of the Golgi apparatus structures located within the postsynapse.
bc
2018-05-08T15:42:56Z
cellular_component
Golgi outpost
GO:0150051
postsynaptic Golgi apparatus
The network of the Golgi apparatus structures located within the postsynapse.
GOC:aruk
GOC:bc
PMID:23838184
Golgi outpost
GOC:aruk
GOC:bc
PMID:21215635
Any process that modulates the frequency, rate or extent of postsynapse assembly, the aggregation, arrangement and bonding together of a set of components to form a postsynapse.
bc
2018-05-08T16:38:55Z
biological_process
GO:0150052
regulation of postsynapse assembly
Any process that modulates the frequency, rate or extent of postsynapse assembly, the aggregation, arrangement and bonding together of a set of components to form a postsynapse.
GOC:aruk
GOC:bc
PMID:16394100
PMID:16672654
PMID:28185854
A synapse of a climbing fiber onto the dendrites of a Purkinje cell in cerebellum. The climbing fiber originates from the inferior olivary nucleus of the medulla oblongata.
bc
2018-05-09T09:57:20Z
cerebellar climbing fibre to Purkinje cell synapse
cellular_component
GO:0150053
cerebellar climbing fiber to Purkinje cell synapse
A synapse of a climbing fiber onto the dendrites of a Purkinje cell in cerebellum. The climbing fiber originates from the inferior olivary nucleus of the medulla oblongata.
GOC:aruk
GOC:bc
PMID:19597563
PMID:23811844
PMID:5044254
Any process that modulates the frequency, rate or extent of postsynaptic neurotransmitter receptor diffusion trapping.
bc
2018-05-10T14:26:59Z
biological_process
GO:0150054
regulation of postsynaptic neurotransmitter receptor diffusion trapping
Any process that modulates the frequency, rate or extent of postsynaptic neurotransmitter receptor diffusion trapping.
GOC:aruk
GOC:bc
PMID:20935643
Any process that modulates the frequency, rate or extent of synaptic vesicle endocytosis.
rl
2012-03-28T01:40:26Z
biological_process
regulation of synaptic vesicle retrieval
GO:1900242
regulation of synaptic vesicle endocytosis
Any process that modulates the frequency, rate or extent of synaptic vesicle endocytosis.
GOC:BHF
GOC:TermGenie
regulation of synaptic vesicle retrieval
GOC:TermGenie
Any process that modulates the frequency, rate or extent of synaptic vesicle lumen acidification.
dsf
2012-10-26T16:09:24Z
regulation of synaptic vesicle lumen pH reduction
regulation of synaptic vesicle lumen proton loading
biological_process
GO:1901546
regulation of synaptic vesicle lumen acidification
Any process that modulates the frequency, rate or extent of synaptic vesicle lumen acidification.
GOC:TermGenie
regulation of synaptic vesicle lumen pH reduction
GOC:TermGenie
regulation of synaptic vesicle lumen proton loading
Any process that modulates the frequency, rate or extent of anterograde synaptic vesicle transport.
kmv
2014-12-12T16:28:27Z
biological_process
GO:1903742
regulation of anterograde synaptic vesicle transport
Any process that modulates the frequency, rate or extent of anterograde synaptic vesicle transport.
GOC:TermGenie
GOC:kmv
GO_REF:0000058
PMID:25329901
Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential.
dos
2015-06-10T18:02:07Z
transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential
ionotropic neurotransmitter receptor activity involved in regulation of post-synaptic membrane potential
ionotropic neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential
molecular_function
GO:1904315
transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential.
GOC:TermGenie
GO_REF:0000061
PMID:20200227
ionotropic neurotransmitter receptor activity involved in regulation of post-synaptic membrane potential
GOC:TermGenie
ionotropic neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential
GOC:TermGenie
Any voltage-gated ion channel activity that is involved in regulation of postsynaptic membrane potential.
https://github.com/geneontology/go-ontology/issues/24479
dos
2016-03-04T15:51:54Z
voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential
voltage gated ion channel activity involved in regulation of post-synaptic membrane potential
voltage gated ion channel activity involved in regulation of postsynaptic membrane potential
voltage-dependent ion channel activity involved in regulation of post-synaptic membrane potential
voltage-dependent ion channel activity involved in regulation of postsynaptic membrane potential
voltage-gated ion channel activity involved in regulation of post-synaptic membrane potential
molecular_function
GO:1905030
voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
Any voltage-gated ion channel activity that is involved in regulation of postsynaptic membrane potential.
GOC:TermGenie
GO_REF:0000061
ISBN:9780071120005
voltage gated ion channel activity involved in regulation of post-synaptic membrane potential
GOC:TermGenie
voltage gated ion channel activity involved in regulation of postsynaptic membrane potential
GOC:TermGenie
voltage-dependent ion channel activity involved in regulation of post-synaptic membrane potential
GOC:TermGenie
voltage-dependent ion channel activity involved in regulation of postsynaptic membrane potential
GOC:TermGenie
voltage-gated ion channel activity involved in regulation of post-synaptic membrane potential
GOC:TermGenie
Any calcium-induced calcium release activity that is involved in regulation of presynaptic cytosolic calcium ion concentration.
dos
2016-03-17T12:12:53Z
calcium-induced calcium release activity involved in regulation of presynaptic cytosolic calcium levels
molecular_function
GO:1905054
calcium-induced calcium release activity involved in regulation of presynaptic cytosolic calcium ion concentration
Any calcium-induced calcium release activity that is involved in regulation of presynaptic cytosolic calcium ion concentration.
GOC:TermGenie
GO_REF:0000061
PMID:15919193
PMID:23918386
calcium-induced calcium release activity involved in regulation of presynaptic cytosolic calcium levels
Any calcium:cation antiporter activity that is involved in regulation of presynaptic cytosolic calcium ion concentration.
dos
2016-03-17T14:35:35Z
calcium:cation antiporter activity involved in regulation of presynaptic cytosolic calcium ion concentration
calcium ion antiporter activity involved in regulation of presynaptic cytosolic calcium levels
molecular_function
GO:1905055
calcium:monoatomic cation antiporter activity involved in regulation of presynaptic cytosolic calcium ion concentration
Any calcium:cation antiporter activity that is involved in regulation of presynaptic cytosolic calcium ion concentration.
GOC:TermGenie
GO_REF:0000061
PMID:22972962
PMID:23255722
calcium ion antiporter activity involved in regulation of presynaptic cytosolic calcium levels
A calcium-transporting P-type ATPase activity involved in regulation of presynaptic cytosolic calcium ion concentration.
dos
2016-03-17T14:35:25Z
ATP phosphohydrolase (Ca2+-transporting) involved in regulation of presynaptic cytosolic calcium ion concentration
ATPase-coupled calcium ion transmembrane transporter activity involved in regulation of presynaptic cytosolic calcium levels
Ca(2+)-transporting ATPase activity involved in regulation of presynaptic cytosolic calcium ion concentration
Ca2+-pumping ATPase activity involved in regulation of presynaptic cytosolic calcium ion concentration
Ca2+-transporting ATPase activity involved in regulation of presynaptic cytosolic calcium ion concentration
calcium transporting ATPase activity involved in regulation of presynaptic cytosolic calcium ion concentration
calcium-transporting ATPase activity involved in regulation of presynaptic cytosolic calcium ion concentration
calcium ABC transporter involved in regulation of presynaptic cytosolic calcium ion concentration
calcium efflux ATPase involved in regulation of presynaptic cytosolic calcium ion concentration
calcium-translocating P-type ATPase activity involved in regulation of presynaptic cytosolic calcium ion concentration
plasma membrane Ca-ATPase involved in regulation of presynaptic cytosolic calcium ion concentration
molecular_function
GO:1905056
P-type calcium transporter activity involved in regulation of presynaptic cytosolic calcium ion concentration
A calcium-transporting P-type ATPase activity involved in regulation of presynaptic cytosolic calcium ion concentration.
GOC:TermGenie
GO_REF:0000061
PMID:22972962
ATP phosphohydrolase (Ca2+-transporting) involved in regulation of presynaptic cytosolic calcium ion concentration
GOC:TermGenie
ATPase-coupled calcium ion transmembrane transporter activity involved in regulation of presynaptic cytosolic calcium levels
Ca(2+)-transporting ATPase activity involved in regulation of presynaptic cytosolic calcium ion concentration
GOC:TermGenie
Ca2+-pumping ATPase activity involved in regulation of presynaptic cytosolic calcium ion concentration
GOC:TermGenie
Ca2+-transporting ATPase activity involved in regulation of presynaptic cytosolic calcium ion concentration
GOC:TermGenie
calcium transporting ATPase activity involved in regulation of presynaptic cytosolic calcium ion concentration
GOC:TermGenie
calcium ABC transporter involved in regulation of presynaptic cytosolic calcium ion concentration
GOC:TermGenie
calcium efflux ATPase involved in regulation of presynaptic cytosolic calcium ion concentration
GOC:TermGenie
calcium-translocating P-type ATPase activity involved in regulation of presynaptic cytosolic calcium ion concentration
GOC:TermGenie
plasma membrane Ca-ATPase involved in regulation of presynaptic cytosolic calcium ion concentration
GOC:TermGenie
Any voltage-gated calcium channel activity that is involved in regulation of postsynaptic cytosolic calcium ion concentration.
dos
2016-03-18T12:31:48Z
depolarization-activated voltage gated calcium channel activity involved in regulation of postsynaptic cytosolic calcium ion concentration
depolarization-activated voltage-gated calcium channel activity involved in regulation of postsynaptic cytosolic calcium ion concentration
depolarization-activated voltage-gated calcium channel involved in regulation of postsynaptic cytosolic calcium ion concentration
voltage gated calcium channel activity involved in regulation of postsynaptic cytosolic calcium ion concentration
voltage-dependent calcium channel activity involved in regulation of postsynaptic cytosolic calcium ion concentration
voltage-gated calcium channel activity involved in regulation of postsynaptic cytosolic calcium levels
voltage-gated calcium ion channel activity involved in regulation of postsynaptic cytosolic calcium ion concentration
voltage-sensitive calcium channel involved in regulation of postsynaptic cytosolic calcium ion concentration
dihydropyridine-sensitive calcium channel activity involved in regulation of postsynaptic cytosolic calcium ion concentration
molecular_function
GO:1905057
voltage-gated calcium channel activity involved in regulation of postsynaptic cytosolic calcium levels
Any voltage-gated calcium channel activity that is involved in regulation of postsynaptic cytosolic calcium ion concentration.
GOC:TermGenie
GO_REF:0000061
PMID:20734177
depolarization-activated voltage gated calcium channel activity involved in regulation of postsynaptic cytosolic calcium ion concentration
GOC:TermGenie
depolarization-activated voltage-gated calcium channel activity involved in regulation of postsynaptic cytosolic calcium ion concentration
GOC:TermGenie
depolarization-activated voltage-gated calcium channel involved in regulation of postsynaptic cytosolic calcium ion concentration
GOC:TermGenie
voltage gated calcium channel activity involved in regulation of postsynaptic cytosolic calcium ion concentration
GOC:TermGenie
voltage-dependent calcium channel activity involved in regulation of postsynaptic cytosolic calcium ion concentration
GOC:TermGenie
voltage-gated calcium channel activity involved in regulation of postsynaptic cytosolic calcium levels
voltage-gated calcium ion channel activity involved in regulation of postsynaptic cytosolic calcium ion concentration
GOC:TermGenie
voltage-sensitive calcium channel involved in regulation of postsynaptic cytosolic calcium ion concentration
GOC:TermGenie
dihydropyridine-sensitive calcium channel activity involved in regulation of postsynaptic cytosolic calcium ion concentration
GOC:TermGenie
Any calcium-induced calcium release activity that is involved in regulation of postsynaptic cytosolic calcium ion concentration.
dos
2016-03-18T12:31:59Z
calcium-induced calcium release activity involved in regulation of postsynaptic cytosolic calcium levels
molecular_function
GO:1905058
calcium-induced calcium release activity involved in regulation of postsynaptic cytosolic calcium ion concentration
Any calcium-induced calcium release activity that is involved in regulation of postsynaptic cytosolic calcium ion concentration.
GOC:TermGenie
GO_REF:0000061
PMID:23639769
calcium-induced calcium release activity involved in regulation of postsynaptic cytosolic calcium levels
A calcium-transporting P-type ATPase activity involved in regulation of postsynaptic cytosolic calcium ion concentration.
dos
2016-03-18T12:32:08Z
ATP phosphohydrolase (Ca2+-transporting) involved in regulation of postsynaptic cytosolic calcium ion concentration
ATPase-coupled calcium ion transmembrane transporter activity involved in regulation of postsynaptic cytosolic calcium levels
Ca(2+)-transporting ATPase activity involved in regulation of postsynaptic cytosolic calcium ion concentration
Ca2+-pumping ATPase activity involved in regulation of postsynaptic cytosolic calcium ion concentration
Ca2+-transporting ATPase activity involved in regulation of postsynaptic cytosolic calcium ion concentration
calcium transporting ATPase activity involved in regulation of postsynaptic cytosolic calcium ion concentration
calcium-transporting ATPase activity involved in regulation of postsynaptic cytosolic calcium ion concentration
calcium-transporting ATPase activity involved in regulation of postsynaptic cytosolic calcium levels
calcium ABC transporter involved in regulation of postsynaptic cytosolic calcium ion concentration
calcium efflux ATPase involved in regulation of postsynaptic cytosolic calcium ion concentration
calcium-translocating P-type ATPase activity involved in regulation of postsynaptic cytosolic calcium ion concentration
plasma membrane Ca-ATPase involved in regulation of postsynaptic cytosolic calcium ion concentration
sarco(endo)plasmic reticulum Ca2+-ATPase involved in regulation of postsynaptic cytosolic calcium ion concentration
sarcoplasmic reticulum ATPase involved in regulation of postsynaptic cytosolic calcium ion concentration
molecular_function
GO:1905059
P-type calcium transporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration
A calcium-transporting P-type ATPase activity involved in regulation of postsynaptic cytosolic calcium ion concentration.
GOC:TermGenie
GO_REF:0000061
PMID:20678993
ATP phosphohydrolase (Ca2+-transporting) involved in regulation of postsynaptic cytosolic calcium ion concentration
GOC:TermGenie
ATPase-coupled calcium ion transmembrane transporter activity involved in regulation of postsynaptic cytosolic calcium levels
Ca(2+)-transporting ATPase activity involved in regulation of postsynaptic cytosolic calcium ion concentration
GOC:TermGenie
Ca2+-pumping ATPase activity involved in regulation of postsynaptic cytosolic calcium ion concentration
GOC:TermGenie
Ca2+-transporting ATPase activity involved in regulation of postsynaptic cytosolic calcium ion concentration
GOC:TermGenie
calcium transporting ATPase activity involved in regulation of postsynaptic cytosolic calcium ion concentration
GOC:TermGenie
calcium-transporting ATPase activity involved in regulation of postsynaptic cytosolic calcium levels
calcium ABC transporter involved in regulation of postsynaptic cytosolic calcium ion concentration
GOC:TermGenie
calcium efflux ATPase involved in regulation of postsynaptic cytosolic calcium ion concentration
GOC:TermGenie
calcium-translocating P-type ATPase activity involved in regulation of postsynaptic cytosolic calcium ion concentration
GOC:TermGenie
plasma membrane Ca-ATPase involved in regulation of postsynaptic cytosolic calcium ion concentration
GOC:TermGenie
sarco(endo)plasmic reticulum Ca2+-ATPase involved in regulation of postsynaptic cytosolic calcium ion concentration
GOC:TermGenie
sarcoplasmic reticulum ATPase involved in regulation of postsynaptic cytosolic calcium ion concentration
GOC:TermGenie
Any calcium:cation antiporter activity that is involved in regulation of postsynaptic cytosolic calcium ion concentration.
dos
2016-03-18T12:32:17Z
calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration
calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion levels
molecular_function
GO:1905060
calcium:monoatomic cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration
Any calcium:cation antiporter activity that is involved in regulation of postsynaptic cytosolic calcium ion concentration.
GOC:TermGenie
GO_REF:0000061
PMID:18024055
calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion levels
Any process that modulates the frequency, rate or extent of modification of synaptic structure.
dos
2016-06-09T09:43:40Z
regulation of synapse remodelling
biological_process
GO:1905244
regulation of modification of synaptic structure
Any process that modulates the frequency, rate or extent of modification of synaptic structure.
GOC:TermGenie
GO_REF:0000058
PMID:25164660
regulation of synapse remodelling
GOC:TermGenie
Any process that modulates the frequency, rate or extent of modification of postsynaptic actin cytoskeleton.
dos
2016-06-16T22:34:25Z
regulation of postsynaptic actin cytoskeleton remodelling
biological_process
GO:1905274
regulation of modification of postsynaptic actin cytoskeleton
Any process that modulates the frequency, rate or extent of modification of postsynaptic actin cytoskeleton.
GOC:TermGenie
GO_REF:0000058
PMID:21068295
regulation of postsynaptic actin cytoskeleton remodelling
GOC:TermGenie
Any process that modulates the frequency, rate or extent of postsynapse to nucleus signaling pathway.
dos
2016-10-07T17:03:38Z
regulation of postsynaptic signaling to nucleus
biological_process
GO:1905539
regulation of postsynapse to nucleus signaling pathway
Any process that modulates the frequency, rate or extent of postsynapse to nucleus signaling pathway.
GOC:TermGenie
GO_REF:0000058
ISBN:9780071120005
regulation of postsynaptic signaling to nucleus
GOC:TermGenie
Any process that modulates the frequency, rate or extent of presynapse assembly.
bc
2016-10-27T16:08:13Z
regulation of presynapse biogenesis
regulation of presynaptic terminal assembly
biological_process
GO:1905606
regulation of presynapse assembly
Any process that modulates the frequency, rate or extent of presynapse assembly.
GOC:PARL
GOC:TermGenie
GOC:bc
GO_REF:0000058
PMID:25533483
regulation of presynapse biogenesis
GOC:TermGenie
regulation of presynaptic terminal assembly
GOC:TermGenie
Any mitochondrial calcium uptake that is involved in negative regulation of presynaptic cytosolic calcium concentration.
dos
2016-12-06T10:53:17Z
calcium ion transmembrane import into mitochondrion involved in negative regulation of presynaptic cytosolic calcium concentration
mitochondrial calcium uptake involved in negative regulation of presynaptic cytosolic calcium concentration
biological_process
GO:1905743
calcium import into the mitochondrion involved in negative regulation of presynaptic cytosolic calcium concentration
Any mitochondrial calcium uptake that is involved in negative regulation of presynaptic cytosolic calcium concentration.
GOC:TermGenie
GO_REF:0000060
PMID:26644474
calcium ion transmembrane import into mitochondrion involved in negative regulation of presynaptic cytosolic calcium concentration
GOC:TermGenie
Any process that modulates the frequency, rate or extent of synapse pruning.
tb
2017-01-11T22:03:15Z
regulation of synapse clearance
regulation of synapse disassembly
regulation of synapse elimination
regulation of synapse removal
biological_process
GO:1905806
regulation of synapse pruning
Any process that modulates the frequency, rate or extent of synapse pruning.
GOC:TermGenie
GO_REF:0000058
PMID:27779093
regulation of synapse disassembly
The directed movement of substances in neuronal dense core vesicles along axonal microtubules towards the presynapse.
anterograde dense core granule trafficking
anterograde dense core granule transport
biological_process
GO:1990048
anterograde neuronal dense core vesicle transport
The directed movement of substances in neuronal dense core vesicles along axonal microtubules towards the presynapse.
GOC:kmv
PMID:23358451
The directed movement of neuronal dense core vesicles along axonal microtubules towards the cell body.
pr
2013-02-19T13:31:44Z
retrograde dense core granule trafficking
retrograde dense core granule transport
biological_process
GO:1990049
retrograde neuronal dense core vesicle transport
The directed movement of neuronal dense core vesicles along axonal microtubules towards the cell body.
GOC:kmv
PMID:23358451
PMID:24762653
Any process that modulates the frequency, rate or extent of synaptic vesicle exocytosis.
dph
2011-01-03T08:20:40Z
biological_process
GO:2000300
regulation of synaptic vesicle exocytosis
Any process that modulates the frequency, rate or extent of synaptic vesicle exocytosis.
GOC:obol
BFO:0000062
external
preceded_by
preceded_by
preceded by
BFO:0000063
external
precedes
precedes
precedes
cjm
2012-03-14T10:35:44Z
GOREL:0000040
external
results_in
results_in
This relation is currently used to connect two regulation processes p1 and p2, such that if r1 regulates p1 and r2 regulates p2, and r1 results_in r2 then the regulation of p1 is required for the regulation of p2. For an example of use, see GO:0035958 'regulation of glyoxylate cycle by regulation of transcription from RNA polymerase II promoter'. Note that a precise definition of this relation is under discussion. After it has been formalized it will be added to RO, where it will have a RO ID. Note that the existing identifier and label are subject to change.
results in
GOREL:0001019
external
results_in_division_of
results_in_division_of
use occurs_in
results in division of
GOREL:0002003
external
results_in_distribution_of
results_in_distribution_of
results in distribution of
GOREL:0002004
external
results_in_fission_of
results_in_fission_of
results in fission of
GOREL:0012006
external
results_in_maintenance_of
results_in_maintenance_of
results in maintenance of
RO:0000053
external
bearer_of
bearer_of
bearer of
RO:0000056
external
participates_in
participates_in
participates in
RO:0000057
external
has_participant
has_participant
has participant
RO:0002007
external
bounding_layer_of
bounding_layer_of
bounding layer of
RO:0002008
external
coincident_with
coincident_with
coincident with
RO:0002013
external
has_regulatory_component_activity
has_regulatory_component_activity
has regulatory component activity
RO:0002014
external
has_negative_regulatory_component_activity
has_negative_regulatory_component_activity
has negative regulatory component activity
RO:0002016
external
has_necessary_component_activity
has_necessary_component_activity
has necessary component activity
RO:0002087
external
immediately_preceded_by
immediately_preceded_by
immediately preceded by
RO:0002090
external
immediately_precedes
immediately_precedes
immediately precedes
RO:0002131
external
overlaps
overlaps
overlaps
RO:0002180
external
has_component
has_component
has component
RO:0002215
external
capable_of
capable_of
capable of
RO:0002216
external
capable_of_part_of
capable_of_part_of
capable of part of
RO:0002220
external
adjacent_to
adjacent_to
adjacent to
RO:0002224
external
starts_with
starts_with
starts with
RO:0002230
external
ends_with
ends_with
ends with
RO:0002231
external
has_start_location
has_start_location
has start location
RO:0002232
external
has_end_location
has_end_location
has end location
RO:0002233
external
has_input
has_input
has input
RO:0002234
external
has_output
has_output
has output
RO:0002295
external
results_in_developmental_progression_of
results_in_developmental_progression_of
results in developmental progression of
RO:0002296
external
results_in_development_of
results_in_development_of
results in development of
RO:0002297
external
results_in_formation_of
results_in_formation_of
results in formation of
RO:0002298
external
results_in_morphogenesis_of
results_in_morphogenesis_of
results in morphogenesis of
RO:0002299
external
results_in_maturation_of
results_in_maturation_of
results in maturation of
RO:0002304
external
causally_upstream_of,_positive_effect
causally_upstream_of,_positive_effect
causally upstream of, positive effect
RO:0002305
external
causally_upstream_of,_negative_effect
causally_upstream_of,_negative_effect
causally upstream of, negative effect
RO:0002315
external
results_in_acquisition_of_features_of
results_in_acquisition_of_features_of
results in acquisition of features of
RO:0002332
external
regulates_levels_of
regulates_levels_of
regulates levels of
RO:0002334
external
regulated_by
regulated_by
regulated by
RO:0002335
external
negatively_regulated_by
negatively_regulated_by
negatively regulated by
RO:0002336
external
positively_regulated_by
positively_regulated_by
positively regulated by
RO:0002338
external
has_target_start_location
has_target_start_location
has target start location
RO:0002339
external
has_target_end_location
has_target_end_location
has target end location
RO:0002341
external
results_in_transport_along
results_in_transport_along
results in transport along
RO:0002342
external
results_in_transport_across
results_in_transport_across
results in transport across
RO:0002343
external
results_in_growth_of
results_in_growth_of
results in growth of
RO:0002344
external
results_in_transport_to_from_or_in
results_in_transport_to_from_or_in
results in transport to from or in
RO:0002348
external
results_in_commitment_to
results_in_commitment_to
results in commitment to
RO:0002349
external
results_in_determination_of
results_in_determination_of
results in determination of
RO:0002353
external
output_of
output_of
output of
RO:0002355
external
results_in_structural_organization_of
results_in_structural_organization_of
results in structural organization of
RO:0002356
external
results_in_specification_of
results_in_specification_of
results in specification of
RO:0002404
external
causally_downstream_of
causally_downstream_of
causally downstream of
RO:0002405
external
immediately_causally_downstream_of
immediately_causally_downstream_of
immediately causally downstream of
RO:0002411
external
causally_upstream_of
causally_upstream_of
causally upstream of
RO:0002412
external
immediately_causally_upstream_of
immediately_causally_upstream_of
immediately causally upstream of
RO:0002418
external
causally_upstream_of_or_within
causally_upstream_of_or_within
causally upstream of or within
RO:0002427
external
causally_downstream_of_or_within
causally_downstream_of_or_within
causally downstream of or within
RO:0002505
external
has_intermediate
has_intermediate
has intermediate
RO:0002565
external
results_in_movement_of
results_in_movement_of
results in movement of
RO:0002578
external
directly_regulates
directly_regulates
directly regulates
RO:0002588
external
results_in_assembly_of
results_in_assembly_of
results in assembly of
RO:0002590
external
results_in_disassembly_of
results_in_disassembly_of
results in disassembly of
RO:0002591
external
results_in_remodeling_of
results_in_remodeling_of
results in remodeling of
RO:0002592
external
results_in_organization_of
results_in_organization_of
results in organization of
RO:0002608
external
process_has_causal_agent
process_has_causal_agent
process has causal agent
RO:0002629
external
directly_positively_regulates
directly_positively_regulates
directly positively regulates
RO:0002630
external
directly_negatively_regulates
directly_negatively_regulates
directly negatively regulates
RO:0003000
external
produces
produces
produces
RO:0003001
external
produced_by
produced_by
produced by
RO:0004007
external
has_primary_input_or_output
has_primary_input_or_output
has primary input or output
RO:0004008
external
has_primary_output
has_primary_output
has primary output
RO:0004009
external
has_primary_input
has_primary_input
has primary input
RO:0012001
external
has_small_molecule_activator
has_small_molecule_activator
has small molecule activator
RO:0012003
external
acts_on_population_of
acts_on_population_of
acts on population of
RO:0012008
external
results_in_fusion_of
results_in_fusion_of
results in fusion of
RO:0019000
gene_ontology
regulates_characteristic
regulates_characteristic
regulates characteristic
RO:0019001
gene_ontology
positively_regulates_characteristic
positively_regulates_characteristic
positively regulates characteristic
RO:0019002
gene_ontology
negatively_regulates_characteristic
negatively_regulates_characteristic
negatively regulates characteristic
RO:0040036
external
results_in_changes_to_anatomical_or_cellular_structure
results_in_changes_to_anatomical_or_cellular_structure
results in changes to anatomical or cellular structure