format-version: 1.2 data-version: go/releases/2023-02-28/imports/pr_import.owl ontology: go/imports/pr_import [Term] id: PR:000000001 name: protein def: "An amino acid chain that is produced de novo by ribosome-mediated translation of a genetically-encoded mRNA, and any derivatives thereof." [] synonym: "native protein" NARROW [] synonym: "natural protein" EXACT [] is_a: PR:000018263 ! amino acid chain is_a: PR:000050567 ! protein-containing material entity intersection_of: PR:000018263 ! amino acid chain intersection_of: has_gene_template SO:0000704 intersection_of: output_of GO:0006412 relationship: has_gene_template SO:0000704 relationship: has_part PR:000000001 ! protein relationship: output_of GO:0006412 [Term] id: PR:000000008 name: TGF-beta-like cystine-knot cytokine def: "A protein that has a core domain composition consisting of a signal peptide, a variable propeptide region and a Transforming growth factor beta like domain (Pfam:PF00019), which is a cystine-knot domain containing four conserved beta strands, S1-S4, which form two antiparallel beta sheets (SI-S2 and S3-S4) interconnected by three disulfide bridges in a knot-like topology. Cystines [II-V] and [III-VI] form a ring through which the remaining disulfide bond (Cys[I-IV]) penetrates. Insertion of different variable regions into this common motif has given rise to various subclasses of the growth factor cystine-knot domain." [] synonym: "TGF-beta superfamily" RELATED [] is_a: PR:000000001 ! protein [Term] id: PR:000000017 name: interferon gamma def: "A type II interferon that is a translation product of the human IFNG gene or a 1:1 ortholog thereof. The core domain structure consists of an Interferon gamma domain (Pfam:PF00714) that is four-helical cytokine domain with an additional helix in one of the crossover connections. It is a cytokine produced by lymphocytes activated by specific antigens or mitogens that has important immunoregulatory functions." [] synonym: "IFN-gamma" EXACT [] synonym: "IFNG" EXACT [] synonym: "immune interferon" EXACT [] is_a: PR:000024990 ! type II interferon [Term] id: PR:000000019 name: mitogen-activated protein kinase def: "A protein that is a serine/threonine-specific protein kinase that responds to extracellular stimuli (mitogens) and regulates cellular activities such as gene expression, mitosis, differentiation, and cell survival/apoptosis. The activated form phosphorylates target substrates on Ser or Thr residues followed by a proline. A distinguishing feature is the conserved sequence TxY." [] synonym: "kinase-related transforming protein" RELATED [] synonym: "MAPK" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000000028 name: small GTPase def: "A protein that has a core domain composition consisting of a Ras family domain (Pfam:PF00071). The small GTPases are monomeric G-proteins which function as GDP/GTP-regulated molecular switches." [] is_a: PR:000000001 ! protein [Term] id: PR:000000033 name: tumor necrosis factor, TNF-like def: "A protein that has a core domain composition consisting of an N-terminal cytosolic domain, a type II transmembrane domain and a C-terminal TNF domain (Pfam:PF00229)." [] is_a: PR:000000001 ! protein [Term] id: PR:000000034 name: bone morphogenetic protein def: "A TGF-beta-like cystine-knot cytokine that is related to the transforming growth factor-beta, anti-Muellerian hormone, and activin/inhibin protein families, which are all involved in the regulation of cell growth and differentiation. These are produced as dimeric precursors and undergo post-translational processing for activation, requiring cleavage to release bioactive the C-terminal peptide. BMP is involved in body patterning and morphogenesis. BMP signals are transmitted through specific type 2 and type 1 receptors." [] is_a: PR:000000008 ! TGF-beta-like cystine-knot cytokine [Term] id: PR:000000046 name: TGF-beta def: "A TGF-beta-like cystine-knot cytokine whose propeptide region is a latent associated peptide (LAP) that remains associated to the mature TGF-beta after cleavage and secretion, keeping TGF-beta inactive. TGF-beta is the founding member of the cystine-knot cytokine family, and is related to the activin/inhibin, anti-Muellerian hormone, and bone morphogenic protein families, which are all involved in the regulation of cell growth and differentiation." [] synonym: "transforming growth factor beta" EXACT [] is_a: PR:000000008 ! TGF-beta-like cystine-knot cytokine [Term] id: PR:000000105 name: nodal protein def: "A TGF-beta-like cystine-knot cytokine that is a translation product of the human NODAL gene or a 1:1 ortholog thereof. The nodal and lefty genes form positive and negative regulatory loops that resemble the reaction-diffusion system. As a pair, these genes control various events of vertebrate embryonic patterning, including left-right specification and mesoderm formation." [] synonym: "NODAL" EXACT [] is_a: PR:000000008 ! TGF-beta-like cystine-knot cytokine [Term] id: PR:000001004 name: CD4 molecule def: "A protein that is a translation product of the human CD4 gene or a 1:1 ortholog thereof. CD4 is an accessory protein for MHC class-II antigen/T-cell receptor interaction. It is the primary receptor for HIV-1. CD4 has four immunoglobulin-like domains in its extracellular region that share the same structure, but can differ in sequence." [] synonym: "CD4" EXACT [] synonym: "T-cell differentiation antigen L3T4" EXACT [] synonym: "T-cell surface antigen T4/Leu-3" EXACT [] synonym: "T-cell surface glycoprotein CD4" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000001091 name: interleukin-1 def: "A protein that has a core domain composition consisting of a propeptide region and an Interleukin-1 / 18 domain." [] is_a: PR:000000001 ! protein [Term] id: PR:000001092 name: interleukin-17 def: "A protein that is a T cell-derived cytokine that may play an important role in the initiation or maintenance of the proinflammatory response. Except for IL-17B, all other IL-17 family members are homodimers containing five highly conserved cysteine residues forming characteristic cystein-knot structure, similar to that found in the TGF-beta-like cystine-knot (PR:000000008). This class consists of six cytokines. Among them, interleukin 17A (IL-17) and IL-17F are expressed by a novel subset of CD4+ helper T (Th) cells and play a critical role in inflammation and autoimmunity. On the other hand, IL-17E, also called IL-25, has been associated with allergic responses." [] synonym: "fam:IL-17" EXACT [] synonym: "IL17" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000001094 name: rhodopsin-like G-protein coupled receptor def: "A G-protein coupled receptor that contains the 7 transmembrane receptor (rhodopsin family) domain (Pfam:PF00001), which includes 7 transmembrane helices (TMI-TM7) with 3 intracellular loops (IL1-IL3) and 3 extracellular loops (EL1-EL3) between the helices. The amino-terminal region is extracellular and the carboxyl-terminal region is intracellular. Rhodopsin-like G-protein coupled receptors (GPCRs) are unique among the several classes of GPCRs in that most have a very short amino-terminal segment and several characteristic sequence motifs, particularly NSxxNPxxY in TM7 and D/E-R-Y/F between TM3 and loop IL2. Most bind their ligands within a cavity between the TM regions." [] synonym: "class 1 G-protein coupled receptor" EXACT [] synonym: "class A G-protein coupled receptor" EXACT [] synonym: "fam:rhodopsin" EXACT [] is_a: PR:000030035 ! G-protein coupled receptor [Term] id: PR:000001095 name: secretin-like G-protein coupled receptor def: "A G-protein coupled receptor that contains the 7 transmembrane receptor (secretin family) domain (Pfam:PF00002) and has an amino-terminal segment of about 50-80 residues that contains conserved disulfide bonds and participates in ligand binding." [] synonym: "class 2 G-protein coupled receptor" BROAD [] synonym: "class B G-protein coupled receptor" EXACT [] synonym: "fam:secretin" EXACT [] synonym: "subfamily B1 G-protein coupled receptor" EXACT [] is_a: PR:000030035 ! G-protein coupled receptor [Term] id: PR:000001096 name: Toll-like receptor def: "A protein that has a core domain composition consisting of a signal peptide, an extracellular domain with multiple Leucine rich repeat (Pfam:PF13855) domain (LRR), a cysteine-rich region, a single-pass transmembrane domain and a C-terminal cytoplasmic tail containing a TIR domain (Pfam:PF01582)." [] synonym: "fam:TLR" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000001105 name: C5a anaphylatoxin chemotactic receptor def: "A complement peptide receptor whose active form binds C5a anaphylatoxin." [] is_a: PR:000044643 ! complement peptide receptor [Term] id: PR:000001113 name: interleukin-25 def: "An interleukin-17 that is a translation product of the human IL25 gene or a 1:1 ortholog thereof." [] synonym: "IL-17E" EXACT [] synonym: "IL-25" EXACT [] synonym: "IL17E" RELATED [] synonym: "IL25" EXACT [] synonym: "interleukin-17E" EXACT [] synonym: "UNQ3120/PRO10272" RELATED [] is_a: PR:000001092 ! interleukin-17 [Term] id: PR:000001115 name: alpha-1 adrenergic receptor def: "An adrenoceptor protein whose active form binds adrenaline and related compounds and whose activity is mediated by G proteins that activate a phosphatidylinositol-calcium second messenger system." [] is_a: PR:000044631 ! adrenoceptor protein [Term] id: PR:000001116 name: alpha-2 adrenergic receptor def: "An adrenoceptor protein whose active form binds adrenaline and related compounds and whose activity is mediated by G proteins that cause inhibition of adenylate cyclase." [] is_a: PR:000044631 ! adrenoceptor protein [Term] id: PR:000001119 name: animal opsin def: "A rhodopsin-like G-protein coupled receptor that is a translation product of the human OPN1LW, OPN1MW, OPN1SW, RHO, OPN3, OPN4, or OPN5 genes, 1:1 orthologs thereof, or a semi-ortholog thereof in Metazoa. The active form binds a vitamin A-based retinaldehyde chromophore through a Schiff base linkage to a Lys residue in the seventh transmembrane alpha helix." [] synonym: "opsin receptor" EXACT [] synonym: "type II opsin" EXACT [] is_a: PR:000001094 ! rhodopsin-like G-protein coupled receptor is_a: PR:000036194 ! eukaryotic protein relationship: only_in_taxon NCBITaxon:33208 [Term] id: PR:000001120 name: apelin receptor def: "A rhodopsin-like G-protein coupled receptor that is a translation product of the human APLNR gene or a 1:1 ortholog thereof. The preferred ligand is apelin." [] synonym: "AGTRL1" RELATED [] synonym: "angiotensin receptor-like 1" EXACT [] synonym: "APJ" RELATED [] synonym: "APLNR" EXACT [] synonym: "G-protein coupled receptor APJ" EXACT [] synonym: "G-protein coupled receptor HG11" EXACT [] synonym: "MSR" RELATED [] is_a: PR:000001094 ! rhodopsin-like G-protein coupled receptor [Term] id: PR:000001121 name: beta adrenergic receptor def: "An adrenoceptor protein whose active form binds adrenaline and related compounds and whose activity is mediated by G proteins that cause activation of adenylate cyclase." [] is_a: PR:000044631 ! adrenoceptor protein [Term] id: PR:000001122 name: bombesin receptor def: "A rhodopsin-like G-protein coupled receptor that is a translation product of the human NMBR, GRPR, or BRS3 genes, 1:1 orthologs thereof, or a semi-ortholog thereof. The active form binds bombesin (a 14 amino acid peptide originally isolated from the skin of a frog) or its homologs. Mammalian homologs of bombesin include gastrin-releasing peptide and neuromedin-B." [] is_a: PR:000001094 ! rhodopsin-like G-protein coupled receptor [Term] id: PR:000001123 name: bradykinin receptor def: "A rhodopsin-like G-protein coupled receptor that is a translation product of the human BDKRB1 or BDKRB2 genes, 1:1 orthologs thereof, or a semi-ortholog thereof. The active form binds bradykinin." [] is_a: PR:000001094 ! rhodopsin-like G-protein coupled receptor [Term] id: PR:000001128 name: chemokine receptor def: "A rhodopsin-like G-protein coupled receptor that in active form binds to one or more chemokines." [] is_a: PR:000001094 ! rhodopsin-like G-protein coupled receptor [Term] id: PR:000001130 name: cholecystokinin receptor def: "A rhodopsin-like G-protein coupled receptor that is a translation product of the human CCKAR or CCKBR genes, 1:1 orthologs thereof, or a semi-ortholog thereof. The active form binds cholecystokinin (CCK)." [] synonym: "fam:CCK_R" EXACT [] is_a: PR:000001094 ! rhodopsin-like G-protein coupled receptor [Term] id: PR:000001131 name: cysteinyl leukotriene receptor def: "A leukotriene receptor that in active form binds cysteinyl leukotriene." [] is_a: PR:000049997 ! leukotriene receptor [Term] id: PR:000001133 name: endothelin receptor def: "A rhodopsin-like G-protein coupled receptor that is a translation product of the human EDNRA or EDNRB genes, 1:1 orthologs thereof, or pro-orthologs thereof. The active form binds endothelins." [] is_a: PR:000001094 ! rhodopsin-like G-protein coupled receptor [Term] id: PR:000001134 name: growth hormone secretagogue/motilin receptor def: "A rhodopsin-like G-protein coupled receptor whose active form binds either growth hormone secretagogues (principally ghrelin) or motilin. The motilin and ghrelin receptors are about 45% identical in amino acid sequence." [] is_a: PR:000001094 ! rhodopsin-like G-protein coupled receptor [Term] id: PR:000001141 name: interleukin-17D def: "An interleukin-17 that is a translation product of the human IL17D gene or a 1:1 ortholog thereof." [] synonym: "IL-17D" EXACT [] synonym: "IL-27" EXACT [] synonym: "IL17D" EXACT [] synonym: "IL27" RELATED [] synonym: "interleukin-27" EXACT [] synonym: "UNQ3096/PRO21175" RELATED [] is_a: PR:000001092 ! interleukin-17 [Term] id: PR:000001146 name: melanocortin receptor def: "A rhodopsin-like G-protein coupled receptor that is a translation product of the human MC1R to MC5R genes, 1:1 orthologs thereof, or a semi-ortholog thereof. The active form binds one or more melanocortins, the pituitary peptides ACTH and alpha-, beta-, and gamma-melanocyte-stimulating hormone." [] is_a: PR:000001094 ! rhodopsin-like G-protein coupled receptor [Term] id: PR:000001150 name: tachykinin receptor def: "A rhodopsin-like G-protein coupled receptor that is a translation product of the human TACR1 to TACR3 genes, 1:1 orthologs thereof, or a semi-ortholog thereof. These receptors bind tachykinin peptides--neuropeptides of 10-12 amino acids derived from the translation products of the TAC1 and TAC3 genes. Tachykinin receptors are not specific but have different affinities for the various peptides." [] is_a: PR:000001094 ! rhodopsin-like G-protein coupled receptor [Term] id: PR:000001153 name: Toll-like receptor 2 def: "A Toll-like receptor that is a translation product of the human TLR2 gene or a 1:1 ortholog thereof." [] synonym: "CD282" EXACT [] synonym: "TIL4" RELATED [] synonym: "TLR2" EXACT [] synonym: "Toll/interleukin-1 receptor-like protein 4" EXACT [] is_a: PR:000001096 ! Toll-like receptor [Term] id: PR:000001155 name: Toll-like receptor 4 def: "A Toll-like receptor that is a translation product of the human TLR4 gene or a 1:1 ortholog thereof." [] synonym: "CD284" EXACT [] synonym: "Lps" RELATED [] synonym: "TLR4" EXACT [] synonym: "Toll" BROAD [] is_a: PR:000001096 ! Toll-like receptor [Term] id: PR:000001171 name: B1 bradykinin receptor def: "A bradykinin receptor that is a translation product of the human BDKRB1 gene or a 1:1 ortholog thereof. The preferred ligand is bradykinin." [] synonym: "B1R" EXACT [] synonym: "Bdkrb" RELATED [] synonym: "BDKRB1" EXACT [] synonym: "BK-1 receptor" EXACT [] synonym: "BRADYB1" RELATED [] is_a: PR:000001123 ! bradykinin receptor [Term] id: PR:000001172 name: B2 bradykinin receptor def: "A bradykinin receptor that is a translation product of the human BDKRB2 gene or a 1:1 ortholog thereof. The preferred ligand is bradykinin." [] synonym: "B2R" EXACT [] synonym: "BDKRB2" EXACT [] synonym: "BK-2 receptor" EXACT [] synonym: "BKR2" RELATED [] is_a: PR:000001123 ! bradykinin receptor [Term] id: PR:000001182 name: adrenocorticotropic hormone receptor def: "A melanocortin receptor that is a translation product of the human MC2R gene or a 1:1 ortholog thereof. The preferred ligand is ACTH." [] synonym: "ACTH receptor" EXACT [] synonym: "ACTH-R" EXACT [] synonym: "ACTHR" RELATED [] synonym: "adrenocorticotropin receptor" EXACT [] synonym: "MC2-R" EXACT [] synonym: "MC2R" EXACT [] synonym: "melanocortin receptor 2" EXACT [] is_a: PR:000001146 ! melanocortin receptor [Term] id: PR:000001183 name: alpha-1A adrenergic receptor def: "An alpha-1 adrenergic receptor that is a translation product of the human ADRA1A gene or a 1:1 ortholog thereof." [] synonym: "ADRA1A" EXACT [] synonym: "ADRA1C" RELATED [] synonym: "alpha-1A adrenoceptor" EXACT [] synonym: "alpha-1A adrenoreceptor" EXACT [] synonym: "alpha-1C adrenergic receptor" EXACT [] synonym: "alpha-adrenergic receptor 1c" EXACT [] is_a: PR:000001115 ! alpha-1 adrenergic receptor [Term] id: PR:000001184 name: alpha-1B adrenergic receptor def: "An alpha-1 adrenergic receptor that is a translation product of the human ADRA1B gene or a 1:1 ortholog thereof." [] synonym: "ADRA1B" EXACT [] synonym: "alpha-1B adrenoceptor" EXACT [] synonym: "alpha-1B adrenoreceptor" EXACT [] is_a: PR:000001115 ! alpha-1 adrenergic receptor [Term] id: PR:000001185 name: alpha-1D adrenergic receptor def: "An alpha-1 adrenergic receptor that is a translation product of the human ADRA1D gene or a 1:1 ortholog thereof." [] synonym: "ADRA1A" RELATED [] synonym: "ADRA1D" EXACT [] synonym: "alpha-1A adrenergic receptor" RELATED [] synonym: "alpha-1D adrenoceptor" EXACT [] synonym: "alpha-1D adrenoreceptor" EXACT [] synonym: "alpha-adrenergic receptor 1a" EXACT [] synonym: "Gpcr8" RELATED [] is_a: PR:000001115 ! alpha-1 adrenergic receptor [Term] id: PR:000001186 name: alpha-2A adrenergic receptor def: "An alpha-2 adrenergic receptor that is a translation product of the human ADRA2A gene or a 1:1 ortholog thereof." [] synonym: "ADRA2A" EXACT [] synonym: "ADRA2R" RELATED [] synonym: "ADRAR" RELATED [] synonym: "alpha-2 adrenergic receptor subtype C10" EXACT [] synonym: "alpha-2A adrenoceptor" EXACT [] synonym: "alpha-2A adrenoreceptor" EXACT [] synonym: "alpha-2AAR" EXACT [] is_a: PR:000001116 ! alpha-2 adrenergic receptor [Term] id: PR:000001187 name: alpha-2B adrenergic receptor def: "An alpha-2 adrenergic receptor that is a translation product of the human ADRA2B gene or a 1:1 ortholog thereof." [] synonym: "ADRA2B" EXACT [] synonym: "ADRA2L1" RELATED [] synonym: "ADRA2RL1" RELATED [] synonym: "alpha-2 adrenergic receptor subtype C2" EXACT [] synonym: "alpha-2B adrenoceptor" EXACT [] synonym: "alpha-2B adrenoreceptor" EXACT [] synonym: "alpha-2BAR" EXACT [] is_a: PR:000001116 ! alpha-2 adrenergic receptor [Term] id: PR:000001188 name: alpha-2C adrenergic receptor def: "An alpha-2 adrenergic receptor that is a translation product of the human ADRA2C gene or a 1:1 ortholog thereof." [] synonym: "ADRA2C" EXACT [] synonym: "ADRA2L2" RELATED [] synonym: "ADRA2RL2" RELATED [] synonym: "alpha-2 adrenergic receptor subtype C4" EXACT [] synonym: "alpha-2C adrenoceptor" EXACT [] synonym: "alpha-2C adrenoreceptor" EXACT [] synonym: "alpha-2CAR" EXACT [] is_a: PR:000001116 ! alpha-2 adrenergic receptor [Term] id: PR:000001192 name: beta-1 adrenergic receptor def: "A beta adrenergic receptor that is a translation product of the human ADRB1 gene or a 1:1 ortholog thereof." [] synonym: "ADRB1" EXACT [] synonym: "ADRB1R" RELATED [] synonym: "B1AR" RELATED [] synonym: "beta-1 adrenoceptor" EXACT [] synonym: "beta-1 adrenoreceptor" EXACT [] is_a: PR:000001121 ! beta adrenergic receptor [Term] id: PR:000001193 name: beta-2 adrenergic receptor def: "A beta adrenergic receptor that is a translation product of the human ADRB2 gene or a 1:1 ortholog thereof." [] synonym: "ADRB2" EXACT [] synonym: "ADRB2R" RELATED [] synonym: "B2AR" RELATED [] synonym: "beta(2)-adrenergic receptor" EXACT [] synonym: "beta-2 adrenoceptor" EXACT [] synonym: "beta-2 adrenoreceptor" EXACT [] is_a: PR:000001121 ! beta adrenergic receptor [Term] id: PR:000001194 name: beta-3 adrenergic receptor def: "A beta adrenergic receptor that is a translation product of the human ADRB3 gene or a 1:1 ortholog thereof." [] synonym: "ADRB3" EXACT [] synonym: "ADRB3R" RELATED [] synonym: "B3AR" RELATED [] synonym: "B3bar" RELATED [] synonym: "beta-3 adrenoceptor" EXACT [] synonym: "beta-3 adrenoreceptor" EXACT [] is_a: PR:000001121 ! beta adrenergic receptor [Term] id: PR:000001197 name: chemokine receptor CCR1/3/1L def: "A chemokine receptor that is a translation product of the human CCR1 or CCR3 genes, the mouse CCR1L1 gene, 1:1 orthologs thereof, or a semi-ortholog thereof." [] is_a: PR:000001128 ! chemokine receptor [Term] id: PR:000001199 name: C-C chemokine receptor type 2 def: "A chemokine receptor that is a translation product of the human CCR2 gene or a 1:1 ortholog thereof. The preferred ligands include CCL2, CCL7, CCL8, CCL13." [] synonym: "C-C CKR-2" EXACT [] synonym: "CC-CKR-2" EXACT [] synonym: "CCR-2" EXACT [] synonym: "CCR2" EXACT [] synonym: "CD192" EXACT [] synonym: "chemokine receptor CCR2" EXACT [] synonym: "CMKBR2" RELATED [] synonym: "JE/FIC receptor" EXACT [] synonym: "MCP-1 receptor" EXACT [] synonym: "MCP-1-R" EXACT [] synonym: "monocyte chemoattractant protein 1 receptor" EXACT [] is_a: PR:000001128 ! chemokine receptor [Term] id: PR:000001202 name: C-C chemokine receptor type 6 def: "A chemokine receptor that is a translation product of the human CCR6 gene or a 1:1 ortholog thereof. The preferred ligand is CCL20." [] synonym: "C-C CKR-6" EXACT [] synonym: "CC-CKR-6" EXACT [] synonym: "CCR-6" EXACT [] synonym: "CCR6" EXACT [] synonym: "CD196" EXACT [] synonym: "chemokine receptor CCR6" EXACT [] synonym: "chemokine receptor-like 3" EXACT [] synonym: "CKR-L3" EXACT [] synonym: "CKRL3" RELATED [] synonym: "CMKBR6" RELATED [] synonym: "DRY6" EXACT [] synonym: "G-protein coupled receptor 29" EXACT [] synonym: "GPR-CY4" EXACT [] synonym: "GPR29" RELATED [] synonym: "GPRCY4" EXACT [] synonym: "KY411" EXACT [] synonym: "LARC receptor" EXACT [] synonym: "STRL22" RELATED [] is_a: PR:000001128 ! chemokine receptor [Term] id: PR:000001203 name: C-C chemokine receptor type 7 def: "A chemokine receptor that is a translation product of the human CCR7 gene or a 1:1 ortholog thereof. The preferred ligands are CCL19 and CCL21." [] synonym: "BLR2" EXACT [] synonym: "C-C CKR-7" EXACT [] synonym: "CC-CKR-7" EXACT [] synonym: "CCR-7" EXACT [] synonym: "CCR7" EXACT [] synonym: "CD197" EXACT [] synonym: "CDw197" EXACT [] synonym: "chemokine receptor CCR7" EXACT [] synonym: "CMKBR7" RELATED [] synonym: "EBI1" RELATED [] synonym: "Ebi1h" RELATED [] synonym: "EBV-induced G-protein coupled receptor 1" EXACT [] synonym: "epstein-Barr virus-induced G-protein coupled receptor 1" EXACT [] synonym: "EVI1" RELATED [] synonym: "MIP-3 beta receptor" EXACT [] is_a: PR:000001128 ! chemokine receptor [Term] id: PR:000001206 name: CX3C chemokine receptor 1 def: "A chemokine receptor that is a translation product of the human CX3CR1 gene or a 1:1 ortholog thereof. The preferred ligand is CX3CL1." [] synonym: "beta chemokine receptor-like 1" EXACT [] synonym: "C-X3-C CKR-1" EXACT [] synonym: "chemokine receptor CX3CR1" EXACT [] synonym: "CMK-BRL-1" EXACT [] synonym: "CMK-BRL1" EXACT [] synonym: "CMKBRL1" RELATED [] synonym: "CX3CR1" EXACT [] synonym: "fractalkine receptor" EXACT [] synonym: "G-protein coupled receptor 13" EXACT [] synonym: "GPR13" RELATED [] synonym: "V28" EXACT [] is_a: PR:000001128 ! chemokine receptor [Term] id: PR:000001208 name: C-X-C chemokine receptor type 4 def: "A chemokine receptor that is a translation product of the human CXCR4 gene or a 1:1 ortholog thereof. The preferred ligand is CXCL12." [] synonym: "CD184" EXACT [] synonym: "chemokine receptor CXCR4" EXACT [] synonym: "Cmkar4" RELATED [] synonym: "CXC-R4" EXACT [] synonym: "CXCR-4" EXACT [] synonym: "CXCR4" EXACT [] synonym: "FB22" EXACT [] synonym: "fusin" EXACT [] synonym: "HM89" EXACT [] synonym: "LCR1" EXACT [] synonym: "LESTR" EXACT [] synonym: "leukocyte-derived seven transmembrane domain receptor" EXACT [] synonym: "NPYRL" EXACT [] synonym: "PB-CKR" EXACT [] synonym: "pre-B-cell-derived chemokine receptor" EXACT [] synonym: "SDF-1 receptor" EXACT [] synonym: "Sdf1r" RELATED [] synonym: "stromal cell-derived factor 1 receptor" EXACT [] is_a: PR:000001128 ! chemokine receptor [Term] id: PR:000001212 name: chemokine XC receptor 1 def: "A chemokine receptor that is a translation product of the human XCR1 gene or a 1:1 ortholog thereof. The preferred ligands are XCL1 and XCL2." [] synonym: "CCXCR1" RELATED [] synonym: "chemokine receptor XCR1" EXACT [] synonym: "G-protein coupled receptor 5" EXACT [] synonym: "GPR5" RELATED [] synonym: "lymphotactin receptor" EXACT [] synonym: "SCM1 receptor" EXACT [] synonym: "XC chemokine receptor 1" EXACT [] synonym: "XCR1" EXACT [] is_a: PR:000001128 ! chemokine receptor [Term] id: PR:000001221 name: endothelin-1 receptor def: "An endothelin receptor that is a translation product of the human EDNRA gene or a 1:1 ortholog thereof. The active form binds endothelin 1 (ET-1) and ET-2 with much higher affinity than ET-3." [] synonym: "EDNRA" EXACT [] synonym: "endothelin A receptor" EXACT [] synonym: "endothelin receptor A" EXACT [] synonym: "endothelin receptor type A" EXACT [] synonym: "ET-A" BROAD [] synonym: "ET-AR" EXACT [] synonym: "ETA" RELATED [] synonym: "ETA-R" EXACT [] synonym: "ETRA" RELATED [] synonym: "Gpcr10" RELATED [] is_a: PR:000001133 ! endothelin receptor [Term] id: PR:000001223 name: gastrin-releasing peptide receptor def: "A bombesin receptor that is a translation product of the human GRPR gene or a 1:1 ortholog thereof. The preferred ligand is gastrin releasing peptide." [] synonym: "GRP-preferring bombesin receptor" EXACT [] synonym: "GRP-R" EXACT [] synonym: "GRPR" EXACT [] is_a: PR:000001122 ! bombesin receptor [Term] id: PR:000001225 name: growth hormone secretagogue receptor def: "A growth hormone secretagogue/motilin receptor that is a translation product of the human GHSR gene or a 1:1 ortholog thereof. Although its preferred ligand is ghrelin, it also binds other growth hormone releasing peptides and some nonpeptide ligands." [] synonym: "GH-releasing peptide receptor" EXACT [] synonym: "ghrelin receptor" EXACT [] synonym: "GHRP" EXACT [] synonym: "GHS-R" EXACT [] synonym: "GHSR" EXACT [] is_a: PR:000001134 ! growth hormone secretagogue/motilin receptor [Term] id: PR:000001240 name: motilin receptor def: "A growth hormone secretagogue/motilin receptor that is a translation product of the human MLNR gene or a 1:1 ortholog thereof. The preferred ligand is motilin, an intestinal peptide that stimulates contraction of gut smooth muscle." [] synonym: "G-protein coupled receptor 38" EXACT [] synonym: "GPR38" RELATED [] synonym: "MLNR" EXACT [] synonym: "MTLR" RELATED [] synonym: "MTLR1" RELATED [] is_a: PR:000001134 ! growth hormone secretagogue/motilin receptor [Term] id: PR:000001245 name: rhodopsin def: "An animal opsin that is a translation product of the human RHO gene or a 1:1 ortholog thereof." [] synonym: "OPN2" RELATED [] synonym: "opsin-2" EXACT [] synonym: "RHO" EXACT [] is_a: PR:000001119 ! animal opsin [Term] id: PR:000001255 name: C-C chemokine receptor type 3 def: "A chemokine receptor CCR1/3/1L that is a translation product of the human CCR3 gene or a 1:1 ortholog thereof." [] synonym: "C-C CKR-3" EXACT [] synonym: "CC-CKR-3" EXACT [] synonym: "CCR-3" EXACT [] synonym: "CCR3" EXACT [] synonym: "CD193" EXACT [] synonym: "chemokine receptor CCR3" EXACT [] synonym: "CKR3" EXACT [] synonym: "Cmkbr1l2" RELATED [] synonym: "CMKBR3" RELATED [] synonym: "eosinophil eotaxin receptor" EXACT [] synonym: "macrophage inflammatory protein 1-alpha receptor-like 2" EXACT [] synonym: "MIP-1 alpha RL2" EXACT [] is_a: PR:000001197 ! chemokine receptor CCR1/3/1L [Term] id: PR:000001315 name: frizzled-like G-protein coupled receptor def: "A G-protein coupled receptor with core architecture consisting of an Fz domain (Pfam:PF01392), also known as Frizzled CRD (cysteine rich domain), followed by a Frizzled/Smoothened family membrane region (Pfam:PF01534), which includes 7 transmembrane helices, and a cytoplasmic domain containing the motif Lys-Thr-x-x-x-Trp. They generally function as cell-surface receptors for Wnts." [] synonym: "class F G-protein coupled receptor" EXACT [] synonym: "fam:frizzled" EXACT [] is_a: PR:000030035 ! G-protein coupled receptor [Term] id: PR:000001317 name: interleukin-7 def: "A protein that is a translation product of the human IL7 gene or a 1:1 ortholog thereof." [] synonym: "IL-7" EXACT [] synonym: "IL7" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000001327 name: cadherin def: "A protein that has a core domain structure of signal sequence, propeptide, five Cadherin domains (Pfam:PF00028), a transmembrane region, and a Cadherin cytoplasmic region (Pfam:PF01049). Cadherins function as adhesion molecules that mediate Ca2+-dependent cell-cell adhesion in solid tissues." [] is_a: PR:000000001 ! protein [Term] id: PR:000001335 name: class 2 cytokine, IL-10 type def: "A protein with a core domain architecture consisting of an N-terminal Interleukin 10 (Pfam:PF00726) domain." [] is_a: PR:000000001 ! protein [Term] id: PR:000001348 name: erythrocyte membrane protein Rh def: "A protein that is a stand alone version of the Ammonium Transporter Family domain in vertebrates. This protein is related to the ammonium transporters in fungi and bacteria. In mammals, this protein defines the Rh blood group antigens." [] is_a: PR:000000001 ! protein [Term] id: PR:000001349 name: fibroblast growth factor receptor def: "A protein with an extracellular region containing three copies of the Immunoglobulin domain (Pfam:PF00047), a single transmembrane region, and an intracellular region containing a Protein tyrosine kinase domain (Pfam:PF07714). Its active form binds fibroblast growth factor (FGF). FGFs and its receptor comprise a signaling system that is conserved throughout metazoan evolution." [] is_a: PR:000000001 ! protein [Term] id: PR:000001353 name: granulocyte colony-stimulating factor receptor def: "A protein that is a translation product of the human CSF3R gene or a 1:1 ortholog thereof. The active receptor is a homodimer which can bind G-CSF and transduce G-CSF-triggered growth signals into cells. Its extracellular domain contains a sequence of about 200 amino acids which can be found in various cytokine receptors. In addition, it contains an immunoglobulin-like domain and three fibronectin type III domains." [] synonym: "CD114" EXACT [] synonym: "CSF3R" EXACT [] synonym: "Csfgr" RELATED [] synonym: "G-CSF receptor" EXACT [] synonym: "G-CSF-R" EXACT [] synonym: "GCSFR" RELATED [] is_a: PR:000000001 ! protein [Term] id: PR:000001357 name: intercellular adhesion molecule 1/3 def: "A protein with a core domain architecture consisting of an Intercellular adhesion molecule (ICAM), N-terminal domain (Pfam:PF03921), a type of Ig-like domain, and four copies of the Immunoglobulin domain (Pfam:PF00047), most of which are not detected by Pfam." [] synonym: "ICAM" RELATED [] is_a: PR:000000001 ! protein [Term] id: PR:000001366 name: interleukin-11 def: "A protein that is a translation product of the human IL11 gene or a 1:1 ortholog thereof." [] synonym: "adipogenesis inhibitory factor" EXACT [] synonym: "AGIF" EXACT [] synonym: "IL-11" EXACT [] synonym: "IL11" EXACT [] synonym: "oprelvekin" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000001368 name: interleukin-12 subunit alpha def: "A protein that is a translation product of the human IL12A gene or a 1:1 ortholog thereof. It associates with interleukin-12 subunit beta to form the interleukin-23. Interleukin-12 subunit alpha associates with interleukin-27 subunit beta to form the interleukin-35." [] synonym: "CLMF p35" EXACT [] synonym: "cytotoxic lymphocyte maturation factor 35 kDa subunit" EXACT [] synonym: "IL-12 subunit p35" EXACT [] synonym: "IL-12A" EXACT [] synonym: "IL12A" EXACT [] synonym: "NK cell stimulatory factor chain 1" EXACT [] synonym: "NKSF1" RELATED [] is_a: PR:000000001 ! protein [Term] id: PR:000001369 name: interleukin-12 subunit beta def: "A protein that is a translation product of the human IL12B gene or a 1:1 ortholog thereof. Interleukin-12 subunit beta associates with interleukin-12 subunit alpha or interleukin-23 subunit alpha to form the interleukin-23." [] synonym: "CLMF p40" EXACT [] synonym: "cytotoxic lymphocyte maturation factor 40 kDa subunit" EXACT [] synonym: "IL-12 subunit p40" EXACT [] synonym: "IL-12B" EXACT [] synonym: "IL12B" EXACT [] synonym: "NK cell stimulatory factor chain 2" EXACT [] synonym: "NKSF2" RELATED [] is_a: PR:000000001 ! protein [Term] id: PR:000001370 name: interleukin-13 def: "A protein that is a translation product of the human IL13 gene or a 1:1 ortholog thereof. Interleukin-13 is a pleiotropic cytokine which may be important in the regulation of the inflammatory and immune responses. It inhibits inflammatory cytokine production and synergises with IL-2 in regulating interferon-gamma synthesis. The sequences of IL-4 and IL-13 are distantly related." [] synonym: "IL-13" EXACT [] synonym: "IL13" EXACT [] synonym: "NC30" RELATED [] synonym: "T-cell activation protein P600" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000001373 name: interleukin-15 def: "A protein that is a translation product of the human IL15 gene or a 1:1 ortholog thereof." [] synonym: "IL-15" EXACT [] synonym: "IL15" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000001374 name: interleukin-16 def: "A protein that is a translation product of the human IL16 gene or a 1:1 ortholog thereof." [] synonym: "IL16" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000001376 name: interleukin-18 def: "A protein that is a translation product of the human IL18 gene or a 1:1 ortholog thereof." [] synonym: "iboctadekin" EXACT [] synonym: "IFN-gamma-inducing factor" EXACT [] synonym: "IGIF" RELATED [] synonym: "IL-1 gamma" EXACT [] synonym: "IL-18" EXACT [] synonym: "IL18" EXACT [] synonym: "IL1F4" RELATED [] synonym: "interferon gamma-inducing factor" EXACT [] synonym: "interleukin-1 gamma" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000001379 name: interleukin-2 def: "A protein that is a translation product of the human IL2 gene or a 1:1 ortholog thereof. Interleukin-2 has a dual role in maintaining tolerance and contributing to immunity." [] synonym: "aldesleukin" EXACT [] synonym: "IL-2" EXACT [] synonym: "IL2" EXACT [] synonym: "T-cell growth factor" EXACT [] synonym: "TCGF" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000001382 name: interleukin-21 def: "A protein that is a translation product of the human IL21 gene or a 1:1 ortholog thereof." [] synonym: "IL-21" EXACT [] synonym: "IL21" EXACT [] synonym: "Za11" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000001383 name: interleukin-22 def: "A protein that is a translation product of the human IL22 gene or a 1:1 ortholog thereof." [] synonym: "cytokine Zcyto18" EXACT [] synonym: "IL-10-related T-cell-derived-inducible factor" EXACT [] synonym: "IL-22" EXACT [] synonym: "IL-22a" EXACT [] synonym: "IL-TIF" EXACT [] synonym: "IL-TIF alpha" EXACT [] synonym: "IL22" EXACT [] synonym: "Il22a" RELATED [] synonym: "ILTIF" RELATED [] synonym: "Iltifa" RELATED [] synonym: "interleukin-22a" EXACT [] synonym: "UNQ3099/PRO10096" RELATED [] synonym: "ZCYTO18" RELATED [] is_a: PR:000000001 ! protein [Term] id: PR:000001387 name: interleukin-3 def: "A protein that is a translation product of the human IL3 gene or a 1:1 ortholog thereof." [] synonym: "Csfmu" RELATED [] synonym: "hematopoietic growth factor" EXACT [] synonym: "IL-3" EXACT [] synonym: "IL3" EXACT [] synonym: "mast cell growth factor" RELATED [] synonym: "MCGF" EXACT [] synonym: "multipotential colony-stimulating factor" EXACT [] synonym: "P-cell-stimulating factor" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000001389 name: interleukin-33 def: "A protein that is a translation product of the human IL33 gene or a 1:1 ortholog thereof." [] synonym: "C9orf26" RELATED [] synonym: "IL-1F11" EXACT [] synonym: "IL-33" EXACT [] synonym: "IL1F11" RELATED [] synonym: "IL33" EXACT [] synonym: "interleukin-1 family member 11" EXACT [] synonym: "NF-HEV" EXACT [] synonym: "NFHEV" RELATED [] synonym: "nuclear factor from high endothelial venules" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000001391 name: interleukin-4 def: "A protein that is a translation product of the human IL4 gene or a 1:1 ortholog thereof." [] synonym: "B-cell growth factor 1" EXACT [] synonym: "B-cell IgG differentiation factor" EXACT [] synonym: "B-cell stimulatory factor 1" EXACT [] synonym: "binetrakin" EXACT [] synonym: "BSF-1" EXACT [] synonym: "IGG1 induction factor" EXACT [] synonym: "IL-4" EXACT [] synonym: "IL4" EXACT [] synonym: "lymphocyte stimulatory factor 1" EXACT [] synonym: "pitrakinra" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000001392 name: interleukin-5 def: "A protein that is a translation product of the human IL5 gene or a 1:1 ortholog thereof." [] synonym: "B-cell differentiation factor I" EXACT [] synonym: "B-cell growth factor II" EXACT [] synonym: "BCGF-II" EXACT [] synonym: "cytotoxic T-lymphocyte inducer" EXACT [] synonym: "eosinophil differentiation factor" EXACT [] synonym: "IL-5" EXACT [] synonym: "IL5" EXACT [] synonym: "T-cell replacing factor" EXACT [] synonym: "TRF" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000001393 name: interleukin-6 def: "A protein that is a translation product of the human IL6 gene or a 1:1 ortholog thereof." [] synonym: "B-cell hybridoma growth factor" EXACT [] synonym: "B-cell stimulatory factor 2" EXACT [] synonym: "BSF-2" EXACT [] synonym: "CDF" EXACT [] synonym: "CTL differentiation factor" EXACT [] synonym: "hybridoma growth factor" EXACT [] synonym: "IFN-beta-2" EXACT [] synonym: "IFNB2" RELATED [] synonym: "IL-6" EXACT [] synonym: "IL6" EXACT [] synonym: "interferon beta-2" EXACT [] synonym: "interleukin HP-1" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000001395 name: interleukin-8 def: "A protein that is a translation product of the human CXCL8 gene or a 1:1 ortholog thereof." [] synonym: "C-X-C motif chemokine 8" EXACT [] synonym: "CXCL8" EXACT [] synonym: "emoctakin" EXACT [] synonym: "GCP-1" RELATED [] synonym: "granulocyte chemotactic protein 1" EXACT [] synonym: "IL-8" EXACT [] synonym: "IL8" RELATED [] synonym: "MDNCF" EXACT [] synonym: "MONAP" EXACT [] synonym: "monocyte-derived neutrophil chemotactic factor" EXACT [] synonym: "monocyte-derived neutrophil-activating peptide" EXACT [] synonym: "NAP-1" EXACT [] synonym: "neutrophil-activating protein 1" EXACT [] synonym: "protein 3-10C" EXACT [] synonym: "T-cell chemotactic factor" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000001396 name: interleukin-9 def: "A protein that is a translation product of the human IL9 gene or a 1:1 ortholog thereof." [] synonym: "cytokine P40" EXACT [] synonym: "IL-9" EXACT [] synonym: "IL9" EXACT [] synonym: "T-cell growth factor P40" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000001397 name: interleukin-9 receptor def: "A protein that is a translation product of the human IL9R gene or a 1:1 ortholog thereof." [] synonym: "CD129" EXACT [] synonym: "IL-9 receptor" EXACT [] synonym: "IL-9R" EXACT [] synonym: "IL9R" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000001422 name: histamine H1 receptor def: "A histamine receptor that is a translation product of the human HRH1 gene or a 1:1 ortholog thereof." [] synonym: "Bphs" RELATED [] synonym: "H1 histamine receptor" EXACT [] synonym: "H1R" EXACT [] synonym: "HH1R" EXACT [] synonym: "HRH1" EXACT [] is_a: PR:000049994 ! histamine receptor [Term] id: PR:000001423 name: histamine H2 receptor def: "A histamine receptor that is a translation product of the human HRH2 gene or a 1:1 ortholog thereof. The preferred ligand is histamine. This receptor mediates smooth muscle relaxation, gastric acid secretion, and other diverse effects." [] synonym: "gastric receptor I" EXACT [] synonym: "H2 histamine receptor" EXACT [] synonym: "H2R" EXACT [] synonym: "HH2R" EXACT [] synonym: "HRH2" EXACT [] is_a: PR:000049994 ! histamine receptor [Term] id: PR:000001426 name: KiSS-1 receptor def: "A rhodopsin-like G-protein coupled receptor that is a translation product of the human KISS1R gene or a 1:1 ortholog thereof. The preferred ligands are peptides of 10-54 residues derived from the metastasis-suppressor KiSS-1 protein." [] synonym: "AXOR12" RELATED [] synonym: "G-protein coupled receptor 54" EXACT [] synonym: "G-protein coupled receptor OT7T175" EXACT [] synonym: "GPR54" RELATED [] synonym: "hypogonadotropin-1" EXACT [] synonym: "KiSS-1R" EXACT [] synonym: "KISS1R" EXACT [] synonym: "kisspeptins receptor" EXACT [] synonym: "metastin receptor" EXACT [] synonym: "OT7T175" EXACT [] is_a: PR:000001094 ! rhodopsin-like G-protein coupled receptor [Term] id: PR:000001431 name: N-formyl peptide receptor def: "A rhodopsin-like G-protein coupled receptor that is a translation product of the human FPR1, FPR2, or FPR3 genes, 1:1 orthologs thereof, or a semi-ortholog thereof. The active form binds N-formyl methionyl peptides." [] synonym: "formylpeptide receptor" EXACT [] is_a: PR:000001094 ! rhodopsin-like G-protein coupled receptor [Term] id: PR:000001439 name: adenosine receptor protein def: "A rhodopsin-like G-protein coupled receptor that is a translation product of the human ADORA1, ADORA2A, ADORA2B, or ADORA3 genes, 1:1 orthologs thereof, or a semi-ortholog thereof. The active form binds adenosine." [] is_a: PR:000001094 ! rhodopsin-like G-protein coupled receptor [Term] id: PR:000001442 name: blood group Rh(D) polypeptide def: "An erythrocyte membrane protein Rh that is a translation product of the human RHD gene or a 1:1 ortholog thereof." [] synonym: "blood group RhD polypeptide" EXACT [] synonym: "CD240D" EXACT [] synonym: "Rh polypeptide 2" EXACT [] synonym: "RHD" EXACT [] synonym: "rhesus D antigen" EXACT [] synonym: "RhPII" EXACT [] synonym: "RHXIII" EXACT [] is_a: PR:000001348 ! erythrocyte membrane protein Rh [Term] id: PR:000001449 name: fibroblast growth factor receptor 2 def: "A fibroblast growth factor receptor that is a translation product of the human FGFR2 gene or a 1:1 ortholog thereof." [] synonym: "BEK" RELATED [] synonym: "CD332" EXACT [] synonym: "Ect1" RELATED [] synonym: "FGFR-2" EXACT [] synonym: "FGFR2" EXACT [] synonym: "K-sam" EXACT [] synonym: "keratinocyte growth factor receptor" EXACT [] synonym: "KGFR" RELATED [] synonym: "KSAM" RELATED [] is_a: PR:000001349 ! fibroblast growth factor receptor [Term] id: PR:000001457 name: galanin receptor def: "A rhodopsin-like G-protein coupled receptor that is a translation product of the human GALR1 to GALR3 genes, 1:1 orthologs thereof, or a semi-ortholog thereof. The active form binds the neuropeptide galanin." [] is_a: PR:000001094 ! rhodopsin-like G-protein coupled receptor [Term] id: PR:000001463 name: glycoprotein hormone receptor def: "A rhodopsin-like G-protein coupled receptor that is a translation product of the human FSHR, LHCGR, or TSHR genes, 1:1 orthologs thereof, or a semi-ortholog thereof. The active form binds glycoprotein hormones (thyrotropin, follitropin, lutropin, choriogonadotropin)." [] is_a: PR:000001094 ! rhodopsin-like G-protein coupled receptor [Term] id: PR:000001464 name: gonadotropin-releasing hormone receptor def: "A rhodopsin-like G-protein coupled receptor that is a translation product of the human GNRHR or GNRHR2 genes, 1:1 orthologs thereof, or a semi-ortholog thereof. The active form binds gonadotropin-releasing hormone I or II." [] is_a: PR:000001094 ! rhodopsin-like G-protein coupled receptor [Term] id: PR:000001468 name: intercellular adhesion molecule 3 def: "An intercellular adhesion molecule 1/3 that is a translation product of the human ICAM3 gene or a 1:1 ortholog thereof." [] synonym: "CD50" EXACT [] synonym: "CDw50" EXACT [] synonym: "ICAM-3" EXACT [] synonym: "ICAM-R" EXACT [] synonym: "ICAM3" EXACT [] is_a: PR:000001357 ! intercellular adhesion molecule 1/3 [Term] id: PR:000001471 name: interleukin-10 def: "A class 2 cytokine, IL-10 type that is a translation product of the human IL10 gene or a 1:1 ortholog thereof. Active interleukin-10 inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T cells. Structurally, IL-10 is a protein of about 160 amino acids that contains four conserved cysteines involved in disulfide bonds." [] synonym: "CSIF" EXACT [] synonym: "cytokine synthesis inhibitory factor" EXACT [] synonym: "IL-10" EXACT [] synonym: "IL10" EXACT [] is_a: PR:000001335 ! class 2 cytokine, IL-10 type [Term] id: PR:000001472 name: interleukin-19 def: "A class 2 cytokine, IL-10 type that is a translation product of the human IL19 gene or a 1:1 ortholog thereof." [] synonym: "IL-19" EXACT [] synonym: "IL19" EXACT [] synonym: "melanoma differentiation-associated protein-like protein" EXACT [] synonym: "NG.1" EXACT [] synonym: "ZMDA1" RELATED [] is_a: PR:000001335 ! class 2 cytokine, IL-10 type [Term] id: PR:000001473 name: interleukin-20 def: "A class 2 cytokine, IL-10 type that is a translation product of the human IL20 gene or a 1:1 ortholog thereof." [] synonym: "cytokine Zcyto10" EXACT [] synonym: "IL-20" EXACT [] synonym: "IL20" EXACT [] synonym: "UNQ852/PRO1801" RELATED [] synonym: "ZCYTO10" RELATED [] is_a: PR:000001335 ! class 2 cytokine, IL-10 type [Term] id: PR:000001474 name: interleukin-24 def: "A class 2 cytokine, IL-10 type that is a translation product of the human IL24 gene or a 1:1 ortholog thereof." [] synonym: "IL-24" EXACT [] synonym: "IL-4-induced secreted protein" EXACT [] synonym: "IL24" EXACT [] synonym: "MDA-7" EXACT [] synonym: "MDA7" RELATED [] synonym: "melanoma differentiation-associated gene 7 protein" EXACT [] synonym: "ST16" RELATED [] synonym: "suppression of tumorigenicity 16 protein" EXACT [] synonym: "Th2-specific cytokine FISP" EXACT [] is_a: PR:000001335 ! class 2 cytokine, IL-10 type [Term] id: PR:000001475 name: interleukin-26 def: "A class 2 cytokine, IL-10 type that is a translation product of the human IL26 gene or a 1:1 ortholog thereof." [] synonym: "AK155" RELATED [] synonym: "IL-26" EXACT [] synonym: "IL26" EXACT [] synonym: "protein AK155" EXACT [] is_a: PR:000001335 ! class 2 cytokine, IL-10 type [Term] id: PR:000001488 name: muscarinic acetylcholine receptor def: "A rhodopsin-like G-protein coupled receptor that is a translation product of the human CHRM1 to CHRM5 genes, 1:1 orthologs thereof, or a semi-ortholog thereof." [] is_a: PR:000001094 ! rhodopsin-like G-protein coupled receptor [Term] id: PR:000001489 name: neuromedin-U receptor def: "A rhodopsin-like G-protein coupled receptor that is a translation product of the human NMUR1 or NMUR2 genes, 1:1 orthologs thereof, or a semi-ortholog thereof." [] synonym: "fam:NMU_R" EXACT [] synonym: "neuromedin U receptor" EXACT [] is_a: PR:000001094 ! rhodopsin-like G-protein coupled receptor [Term] id: PR:000001497 name: opioid receptor protein def: "A rhodopsin-like G-protein coupled receptor that is a translation product of the human OPRD1, OPRK1, OPRM1, or OPRL1 genes, 1:1 orthologs thereof, or a semi-ortholog thereof." [] is_a: PR:000001094 ! rhodopsin-like G-protein coupled receptor [Term] id: PR:000001498 name: pyroglutamylated RF-amide peptide receptor def: "A rhodopsin-like G-protein coupled receptor that is a translation product of the human QRFPR gene or a 1:1 ortholog thereof." [] synonym: "AQ27" EXACT [] synonym: "G-protein coupled receptor 103" EXACT [] synonym: "GPR103" RELATED [] synonym: "orexigenic neuropeptide QRFP receptor" EXACT [] synonym: "QRFPR" EXACT [] synonym: "SP9155" EXACT [] is_a: PR:000001094 ! rhodopsin-like G-protein coupled receptor [Term] id: PR:000001499 name: orexin receptor def: "A rhodopsin-like G-protein coupled receptor that is a translation product of the human HCRTR1 or HCRTR2 genes, 1:1 orthologs thereof, or a semi-ortholog thereof." [] synonym: "hypocretin receptor" EXACT [] is_a: PR:000001094 ! rhodopsin-like G-protein coupled receptor [Term] id: PR:000001546 name: prolactin-releasing peptide receptor def: "A rhodopsin-like G-protein coupled receptor that is a translation product of the human PRLHR gene or a 1:1 ortholog thereof." [] synonym: "G-protein coupled receptor 10" EXACT [] synonym: "Gm339" RELATED [] synonym: "GPR10" RELATED [] synonym: "GR3" RELATED [] synonym: "PRLHR" EXACT [] synonym: "PrRP receptor" EXACT [] synonym: "PrRPR" EXACT [] is_a: PR:000001094 ! rhodopsin-like G-protein coupled receptor [Term] id: PR:000001548 name: prostaglandin E2 receptor EP4 subtype def: "A prostanoid receptor that is a translation product of the human PTGER4 gene or a 1:1 ortholog thereof. The preferred ligand is prostaglandin E2. This receptor is not closely related to other prostaglandin E2 receptors." [] synonym: "PGE receptor EP4 subtype" EXACT [] synonym: "PGE2 receptor EP4 subtype" EXACT [] synonym: "prostaglandin E2 receptor EP4" EXACT [] synonym: "prostanoid EP4 receptor" EXACT [] synonym: "PTGER2" RELATED [] synonym: "PTGER4" EXACT [] synonym: "Ptgerep4" RELATED [] is_a: PR:000001549 ! prostanoid receptor [Term] id: PR:000001549 name: prostanoid receptor def: "A rhodopsin-like G-protein coupled receptor that is a translation product of the human PTGDR, PTGDR2, PTGER1 to PTGER4, PTGFR, PTGIR, or TBXA2R genes, 1:1 orthologs thereof, or a semi-ortholog thereof. The active form binds prostanoids (prostaglandins and thromboxanes)." [] is_a: PR:000001094 ! rhodopsin-like G-protein coupled receptor [Term] id: PR:000001550 name: proteinase-activated receptor def: "A rhodopsin-like G-protein coupled receptor that is a translation product of the human F2R, or F2RL1 to F2RL3 genes, 1:1 orthologs thereof, or a semi-ortholog thereof. The active form binds trypsin-related proteinases. The proteinase cleaves the mature peptide, exposing a new amino end. The new N-terminal residues act as a tethered ligand that induces activity." [] synonym: "fam:PAR" EXACT [] is_a: PR:000001094 ! rhodopsin-like G-protein coupled receptor [Term] id: PR:000001555 name: somatostatin receptor def: "A rhodopsin-like G-protein coupled receptor that is a translation product of the human SSTR1 to SSTR5 genes, 1:1 orthologs thereof, or a semi-ortholog thereof. The active form binds somatostatin." [] is_a: PR:000001094 ! rhodopsin-like G-protein coupled receptor [Term] id: PR:000001557 name: thyrotropin-releasing hormone receptor type 1 def: "A thyrotropin-releasing hormone receptor that is a translation product of the human TRHR gene or a 1:1 ortholog thereof. The preferred ligand is thyrotropin-releasing hormone." [] synonym: "thyroliberin receptor" EXACT [] synonym: "TRH-R" BROAD [] synonym: "TRH-R1" EXACT [] synonym: "TRHR" EXACT [] is_a: PR:000050029 ! thyrotropin-releasing hormone receptor [Term] id: PR:000001562 name: vasopressin/oxytocin receptor def: "A rhodopsin-like G-protein coupled receptor that is a translation product of the human AVPR1A, AVPR1B, AVPR2, or OXTR genes, 1:1 orthologs thereof, or a semi-ortholog thereof. These receptors bind vasopressin or oxytocin or related nonapeptides." [] synonym: "name: vasopressin and oxytocin receptor" EXACT [] is_a: PR:000001094 ! rhodopsin-like G-protein coupled receptor [Term] id: PR:000001564 name: histamine H3 receptor def: "A histamine receptor that is a translation product of the human HRH3 gene or a 1:1 ortholog thereof. The preferred ligand is histamine. This receptor mediates inhibition of gastric acid release, inhibition of neurotransmitter release, and other diverse effects." [] synonym: "G-protein coupled receptor 97" RELATED [] synonym: "GPCR97" RELATED [] synonym: "H3 histamine receptor" EXACT [] synonym: "H3R" EXACT [] synonym: "HH3R" EXACT [] synonym: "HRH3" EXACT [] is_a: PR:000049994 ! histamine receptor [Term] id: PR:000001565 name: H4 histamine receptor def: "A histamine receptor that is a translation product of the human HRH4 gene or a 1:1 ortholog thereof. The preferred ligand is histamine. This receptor is expressed primarily in the bone marrow and eosinophils but also in a wide variety of peripheral tissues, including the heart, kidney, liver, lung, pancreas, skeletal muscle, prostate, small intestine, spleen, testis, colon, fetal liver and lymph node." [] synonym: "AXOR35" EXACT [] synonym: "G-protein coupled receptor 105" RELATED [] synonym: "GPCR105" RELATED [] synonym: "GPRv53" EXACT [] synonym: "H4R" EXACT [] synonym: "HH4R" EXACT [] synonym: "HRH4" EXACT [] synonym: "Pfi-013" EXACT [] synonym: "SP9144" EXACT [] is_a: PR:000049994 ! histamine receptor [Term] id: PR:000001579 name: delta-type opioid receptor def: "An opioid receptor protein that is a translation product of the human OPRD1 gene or a 1:1 ortholog thereof. The preferred ligands are enkephalins." [] synonym: "D-OR-1" EXACT [] synonym: "delta-opioid receptor" EXACT [] synonym: "DOR-1" EXACT [] synonym: "K56" EXACT [] synonym: "MSL-2" RELATED [] synonym: "OPRD" RELATED [] synonym: "OPRD1" EXACT [] is_a: PR:000001497 ! opioid receptor protein [Term] id: PR:000001590 name: kappa-type opioid receptor def: "An opioid receptor protein that is a translation product of the human OPRK1 gene or a 1:1 ortholog thereof. The preferred ligand is dynorphin." [] synonym: "K-OR-1" EXACT [] synonym: "kappa-opioid receptor" EXACT [] synonym: "KOR-1" EXACT [] synonym: "MSL-1" RELATED [] synonym: "OPRK" RELATED [] synonym: "OPRK1" EXACT [] is_a: PR:000001497 ! opioid receptor protein [Term] id: PR:000001596 name: lutropin-choriogonadotropic hormone receptor def: "A glycoprotein hormone receptor that is a translation product of the human LHCGR gene or a 1:1 ortholog thereof. The preferred ligands are lutropin (luteinizing hormone) and choriogonadotropin (choriogonadotropic hormone)." [] synonym: "LCGR" RELATED [] synonym: "LGR2" RELATED [] synonym: "LH/CG-R" EXACT [] synonym: "LHCGR" EXACT [] synonym: "LHR" EXACT [] synonym: "LHRHR" RELATED [] synonym: "LSH-R" EXACT [] synonym: "luteinizing hormone receptor" EXACT [] synonym: "lutropin/choriogonadotropin receptor" EXACT [] is_a: PR:000001463 ! glycoprotein hormone receptor [Term] id: PR:000001612 name: mu-type opioid receptor def: "An opioid receptor protein that is a translation product of the human OPRM1 gene or a 1:1 ortholog thereof. The preferred ligands are beta-endorphin and enkephalins." [] synonym: "M-OR-1" EXACT [] synonym: "MOP" EXACT [] synonym: "Mor" RELATED [] synonym: "MOR-1" EXACT [] synonym: "MOR1" RELATED [] synonym: "mu opiate receptor" EXACT [] synonym: "mu opioid receptor" EXACT [] synonym: "mu-opioid receptor" EXACT [] synonym: "Oprm" RELATED [] synonym: "OPRM1" EXACT [] is_a: PR:000001497 ! opioid receptor protein [Term] id: PR:000001631 name: nociceptin receptor def: "An opioid receptor protein that is a translation product of the human OPRL1 gene or a 1:1 ortholog thereof. The preferred ligand is nociceptin." [] synonym: "K3 opiate receptor" EXACT [] synonym: "kappa-type 3 opioid receptor" EXACT [] synonym: "KOR-3" EXACT [] synonym: "OOR" RELATED [] synonym: "Oprl" RELATED [] synonym: "OPRL1" EXACT [] synonym: "ORGC" EXACT [] synonym: "ORL1" RELATED [] synonym: "orphanin FQ receptor" EXACT [] is_a: PR:000001497 ! opioid receptor protein [Term] id: PR:000001635 name: oxytocin receptor def: "A vasopressin/oxytocin receptor that is a translation product of the human OXTR gene or a 1:1 ortholog thereof. The preferred ligand is oxytocin." [] synonym: "OT-R" EXACT [] synonym: "OXTR" EXACT [] is_a: PR:000001562 ! vasopressin/oxytocin receptor [Term] id: PR:000001655 name: prostacyclin receptor def: "A prostanoid receptor that is a translation product of the human PTGIR gene or a 1:1 ortholog thereof. The preferred ligand is prostacyclin (prostaglandin I2, PGI2). This receptor is widely distributed in blood platelets, vascular smooth muscle and nerve cells." [] synonym: "PGI receptor" EXACT [] synonym: "PGI2 receptor" EXACT [] synonym: "PRIPR" RELATED [] synonym: "prostaglandin I2 receptor" EXACT [] synonym: "prostanoid IP receptor" EXACT [] synonym: "PTGIR" EXACT [] is_a: PR:000001549 ! prostanoid receptor [Term] id: PR:000001656 name: prostaglandin D2 receptor def: "A prostanoid receptor that is a translation product of the human PTGDR gene or a 1:1 ortholog thereof. The preferred ligand is prostaglandin D2 (PGD2). This receptor is found mainly in blood platelets, vascular smooth muscle, and nervous tissue. It is the least upiquitous of the prostanoid receptors, almost always occurring in association with other prostanoid receptor types." [] synonym: "PGD receptor" EXACT [] synonym: "PGD2 receptor" EXACT [] synonym: "prostanoid DP receptor" EXACT [] synonym: "PTGDR" EXACT [] is_a: PR:000001549 ! prostanoid receptor [Term] id: PR:000001657 name: prostaglandin E2 receptor EP1 subtype def: "A prostanoid receptor that is a translation product of the human PTGER1 gene or a 1:1 ortholog thereof. The preferred ligand is prostaglandin E2 (PGE2). This receptor has limited expression, although it is more evident in rodents than in other mammals." [] synonym: "PGE receptor EP1 subtype" EXACT [] synonym: "PGE2 receptor EP1 subtype" EXACT [] synonym: "prostaglandin E2 receptor EP1" EXACT [] synonym: "prostanoid EP1 receptor" EXACT [] synonym: "PTGER1" EXACT [] synonym: "Ptgerep1" RELATED [] is_a: PR:000001549 ! prostanoid receptor [Term] id: PR:000001658 name: prostaglandin E2 receptor EP2 subtype def: "A prostanoid receptor that is a translation product of the human PTGER2 gene or a 1:1 ortholog thereof. The preferred ligand is prostaglandin E2 (PGE2). This receptor is expressed mediates various effects, including relaxation of vascular smooth muscles, nonacid secretion from epithelial cells, inhibition of mediator release from mast cells and basophils, and activation of sensory afferent nerves." [] synonym: "PGE receptor EP2 subtype" EXACT [] synonym: "PGE2 receptor EP2 subtype" EXACT [] synonym: "prostaglandin E2 receptor EP2" EXACT [] synonym: "prostanoid EP2 receptor" EXACT [] synonym: "PTGER2" EXACT [] synonym: "Ptgerep2" RELATED [] is_a: PR:000001549 ! prostanoid receptor [Term] id: PR:000001659 name: prostaglandin E2 receptor EP3 subtype def: "A prostanoid receptor that is a translation product of the human PTGER3 gene or a 1:1 ortholog thereof. The preferred ligand is prostaglandin E2 (PGE2). This receptor is the most ubiquitous of the prostaglandin E2 receptors, mediating contraction of gastrointestinal, uterine, and vascular smooth muscle, inhibition of neurotransmitter release from autonomic nerves, inhibition of lipolysis in adipocytes, inhibition of acid secretion from gastric mucosa, and inhibition of water reabsorption in kidney." [] synonym: "PGE receptor EP3 subtype" EXACT [] synonym: "PGE2 receptor EP3 subtype" EXACT [] synonym: "PGE2-R" EXACT [] synonym: "prostaglandin E2 receptor EP3" EXACT [] synonym: "prostanoid EP3 receptor" EXACT [] synonym: "PTGER3" EXACT [] synonym: "Ptgerep3" RELATED [] is_a: PR:000001549 ! prostanoid receptor [Term] id: PR:000001660 name: prostaglandin F2-alpha receptor def: "A prostanoid receptor that is a translation product of the human PTGFR gene or a 1:1 ortholog thereof. The preferred ligand is prostaglandin F2a. This receptor is particularly prevalent in the corpus luteum, but is expressed in other tissues also." [] synonym: "PGF receptor" EXACT [] synonym: "PGF2-alpha receptor" EXACT [] synonym: "prostanoid FP receptor" EXACT [] synonym: "PTGFR" EXACT [] is_a: PR:000001549 ! prostanoid receptor [Term] id: PR:000001661 name: proteinase-activated receptor 1 def: "A proteinase-activated receptor that is a translation product of the human F2R gene or a 1:1 ortholog thereof. It is activated by thrombin, which cleaves the mature peptide, exposing a new amino end. The new N-terminal residues act as a tethered ligand that induces activity." [] synonym: "CF2R" RELATED [] synonym: "coagulation factor II receptor" EXACT [] synonym: "F2R" EXACT [] synonym: "PAR-1" EXACT [] synonym: "PAR1" RELATED [] synonym: "thrombin receptor" EXACT [] synonym: "TR" RELATED [] is_a: PR:000001550 ! proteinase-activated receptor [Term] id: PR:000001676 name: thromboxane A2 receptor def: "A prostanoid receptor that is a translation product of the human TBXA2R gene or a 1:1 ortholog thereof. The preferred ligand is thromboxane A2. This receptor is found mainly in vascular smooth muscle, where it mediates vasoconstriction, in platelets, where it mediates aggregation, and in airway smooth muscle." [] synonym: "prostanoid TP receptor" EXACT [] synonym: "TBXA2R" EXACT [] synonym: "TXA2-R" EXACT [] is_a: PR:000001549 ! prostanoid receptor [Term] id: PR:000001753 name: transcription factor NF-kappa-B subunit def: "A protein that has a core domain composition consisting of a Rel homology domain (RHD) (Pfam:PF00554), an IPT/TIG domain (Pfam:PF01833), six copies of the Ankyrin repeat (Pfam:PF00023), a Death domain (Pfam:PF00531) and a C-terminal PEST region." [] synonym: "transcription factor NF-kappa-B" RELATED [] is_a: PR:000000001 ! protein [Term] id: PR:000001808 name: C/C-C motif small inducible chemokine def: "A protein with core architecture consisting of a Small cytokines (intecrine/chemokine), interleukin-8 like (Pfam:PF00048) domain." [] synonym: "fam:C/C-C chemokine" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000001810 name: CSF-1/PDGF receptor-type tyrosine-protein kinase def: "A protein with core architecture consisting of asignal sequence, 5 Ig-like domains, followed by a transmembrane sequence, followed by a Protein tyrosine kinase domain (Pfam:PF07714). However, only 1-3 of the Ig domains are detected by the Pfam HMMs in most of the sequences. Pfam:PF00047 is most common, but other members of the Ig domain clan, Pfam:PF07679 and Pfam:PF07686 can be identified instead. The fourth Ig domain lacks the disulfide-bonded cysteines." [] is_a: PR:000000001 ! protein [Term] id: PR:000001812 name: EGF receptor type tyrosine-protein kinase def: "A protein with core architecture consisting of a signal sequence, a Receptor L domain (Pfam:PF01030), a Furin-like cysteine rich region (Pfam:PF00757), another Receptor L domain, a transmembrane domain, and a Protein tyrosine kinase domain (Pfam:PF07714), that may be followed by up to two YLP motifs (Pfam:PF02757)." [] is_a: PR:000000001 ! protein [Term] id: PR:000001816 name: HGF/MSP receptor type tyrosine-protein kinase def: "A protein with core architecture consisting of a signal sequence, followed by a Sema domain (Pfam:PF01403), three IPT/TIG domains (Pfam:PF01833), a transmembrane region, and a Protein tyrosine kinase domain (Pfam:PF07714)." [] is_a: PR:000000001 ! protein [Term] id: PR:000001876 name: leukemia inhibitory factor receptor def: "A protein that is a translation product of the human LIFR gene or a 1:1 ortholog thereof." [] synonym: "CD118" EXACT [] synonym: "D-factor/LIF receptor" EXACT [] synonym: "LIF receptor" EXACT [] synonym: "LIF-R" EXACT [] synonym: "LIFR" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000001887 name: melanotransferrin def: "A protein that is a translation product of the human MELTF gene or a 1:1 ortholog thereof." [] synonym: "CD228" EXACT [] synonym: "MAP97" RELATED [] synonym: "melanoma-associated antigen p97" EXACT [] synonym: "MELTF" EXACT [] synonym: "membrane-bound transferrin-like protein p97" EXACT [] synonym: "MFI2" RELATED [] synonym: "MTf" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000001902 name: nuclear receptor ROR-gamma def: "A protein that is a translation product of the human RORC gene or a 1:1 ortholog thereof." [] synonym: "NR1F3" RELATED [] synonym: "nuclear receptor RZR-gamma" EXACT [] synonym: "nuclear receptor subfamily 1 group F member 3" EXACT [] synonym: "RAR-related orphan receptor C" EXACT [] synonym: "retinoid-related orphan receptor-gamma" EXACT [] synonym: "RORC" EXACT [] synonym: "RORG" RELATED [] synonym: "RZRG" RELATED [] synonym: "Thor" RELATED [] synonym: "thymus orphan receptor" EXACT [] synonym: "TOR" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000001926 name: semaphorin def: "A protein with core architecture consisting of a signal sequence,a Sema domain (Pfam:PF01403), a Plexin repeat (Pfam:PF01437), and an Ig-like domain (Pfam:PF00047, Pfam:PF07686, or Pfam:PF07679)." [] is_a: PR:000000001 ! protein [Term] id: PR:000001946 name: tumor necrosis factor ligand superfamily member 10/11 def: "A protein with core architecture consisting of a fairly small cytoplasmic region, a transmembrane domain, and an extracellular domain containing a TNF(Tumour Necrosis Factor) family domain (Pfam:PF00229)." [] is_a: PR:000000001 ! protein [Term] id: PR:000001971 name: vascular endothelial growth factor receptor def: "A protein with core architecture consisting of a signal sequence, followed by 7 Ig-like domains (Pfam:PF00047, Pfam:PF07679, or Pfam:PF07686), a transmembrane region, and a cytoplasmic Protein tyrosine kinase domain." [] is_a: PR:000000001 ! protein [Term] id: PR:000001991 name: C-C motif chemokine 19 def: "A C/C-C motif small inducible chemokine that is a translation product of the human CCL19 gene or a 1:1 ortholog thereof." [] synonym: "beta chemokine exodus-3" EXACT [] synonym: "CCL19" EXACT [] synonym: "CK beta-11" EXACT [] synonym: "EBI1 ligand chemokine" EXACT [] synonym: "ELC" RELATED [] synonym: "epstein-Barr virus-induced molecule 1 ligand chemokine" EXACT [] synonym: "macrophage inflammatory protein 3 beta" EXACT [] synonym: "MIP-3-beta" EXACT [] synonym: "MIP3B" RELATED [] synonym: "SCYA19" RELATED [] synonym: "small-inducible cytokine A19" EXACT [] is_a: PR:000001808 ! C/C-C motif small inducible chemokine [Term] id: PR:000001993 name: C-C motif chemokine 21 def: "A C/C-C motif small inducible chemokine that is a translation product of the human CCL21 gene or a 1:1 ortholog thereof." [] synonym: "6Ckine" BROAD [] synonym: "beta chemokine exodus-2" EXACT [] synonym: "CCL21" EXACT [] synonym: "Ccl21b" RELATED [] synonym: "Ccl21c" RELATED [] synonym: "SCYA21" RELATED [] synonym: "Scya21b" RELATED [] synonym: "Scya21c" RELATED [] synonym: "secondary lymphoid-tissue chemokine" EXACT [] synonym: "SLC" EXACT [] synonym: "small-inducible cytokine A21" EXACT [] synonym: "small-inducible cytokine A21a" BROAD [] synonym: "small-inducible cytokine A21b" BROAD [] synonym: "small-inducible cytokine A21c" BROAD [] synonym: "TCA4" BROAD [] synonym: "thymus-derived chemotactic agent 4" BROAD [] synonym: "UNQ784/PRO1600" RELATED [] is_a: PR:000001808 ! C/C-C motif small inducible chemokine [Term] id: PR:000002038 name: eotaxin-like cytokine def: "A C/C-C motif small inducible chemokine that is a member of a subfamily that includes eotaxin." [] is_a: PR:000001808 ! C/C-C motif small inducible chemokine [Term] id: PR:000002065 name: mast/stem cell growth factor receptor def: "A CSF-1/PDGF receptor-type tyrosine-protein kinase that is a translation product of the human KIT gene or a 1:1 ortholog thereof." [] synonym: "CD117" EXACT [] synonym: "KIT" EXACT [] synonym: "proto-oncogene c-Kit" EXACT [] synonym: "SCFR" RELATED [] synonym: "Sl" RELATED [] synonym: "tyrosine-protein kinase Kit" EXACT [] is_a: PR:000001810 ! CSF-1/PDGF receptor-type tyrosine-protein kinase [Term] id: PR:000002094 name: C-C motif chemokine 5 def: "A C/C-C motif small inducible chemokine that is a translation product of the human CCL5 gene or a 1:1 ortholog thereof." [] synonym: "CCL5" EXACT [] synonym: "D17S136E" RELATED [] synonym: "EoCP" EXACT [] synonym: "eosinophil chemotactic cytokine" RELATED [] synonym: "RANTES" EXACT [] synonym: "SCYA5" RELATED [] synonym: "SIS-delta" EXACT [] synonym: "small inducible cytokine A5" EXACT [] synonym: "small-inducible cytokine A5" EXACT [] synonym: "T cell-specific protein P228" EXACT [] synonym: "T-cell-specific protein RANTES" EXACT [] synonym: "TCP228" EXACT [] is_a: PR:000001808 ! C/C-C motif small inducible chemokine [Term] id: PR:000002106 name: tumor necrosis factor ligand superfamily member 10 def: "A tumor necrosis factor ligand superfamily member 10/11 that is a translation product of the human TNFSF10 gene or a 1:1 ortholog thereof." [] synonym: "apo-2 ligand" EXACT [] synonym: "apo-2L" EXACT [] synonym: "APO2L" RELATED [] synonym: "CD253" EXACT [] synonym: "protein TRAIL" EXACT [] synonym: "TNF-related apoptosis-inducing ligand" EXACT [] synonym: "TNFSF10" EXACT [] synonym: "TRAIL" RELATED [] is_a: PR:000001946 ! tumor necrosis factor ligand superfamily member 10/11 [Term] id: PR:000002107 name: tumor necrosis factor ligand superfamily member 11 def: "A tumor necrosis factor ligand superfamily member 10/11 that is a translation product of the human TNFSF11 gene or a 1:1 ortholog thereof." [] synonym: "CD254" EXACT [] synonym: "ODF" EXACT [] synonym: "OPGL" RELATED [] synonym: "osteoclast differentiation factor" EXACT [] synonym: "osteoprotegerin ligand" EXACT [] synonym: "RANKL" RELATED [] synonym: "receptor activator of nuclear factor kappa-B ligand" EXACT [] synonym: "TNF-related activation-induced cytokine" EXACT [] synonym: "TNFSF11" EXACT [] synonym: "TRANCE" RELATED [] is_a: PR:000001946 ! tumor necrosis factor ligand superfamily member 10/11 [Term] id: PR:000002112 name: vascular endothelial growth factor receptor 2 def: "A vascular endothelial growth factor receptor that is a translation product of the human KDR gene or a 1:1 ortholog thereof." [] synonym: "CD309" EXACT [] synonym: "fetal liver kinase 1" EXACT [] synonym: "FLK-1" EXACT [] synonym: "FLK1" RELATED [] synonym: "KDR" EXACT [] synonym: "kinase insert domain receptor" EXACT [] synonym: "kinase NYK" EXACT [] synonym: "protein-tyrosine kinase receptor flk-1" EXACT [] synonym: "VEGFR-2" EXACT [] synonym: "VEGFR2" RELATED [] is_a: PR:000001971 ! vascular endothelial growth factor receptor [Term] id: PR:000002122 name: C-C motif chemokine 2 def: "An eotaxin-like cytokine that is a translation product of the human CCL2 gene or a 1:1 ortholog thereof." [] synonym: "CCL2" EXACT [] synonym: "HC11" EXACT [] synonym: "Je" RELATED [] synonym: "MCAF" EXACT [] synonym: "MCP-1" BROAD [] synonym: "MCP1" RELATED [] synonym: "monocyte chemoattractant protein 1" EXACT [] synonym: "monocyte chemotactic and activating factor" EXACT [] synonym: "monocyte chemotactic protein 1" EXACT [] synonym: "monocyte secretory protein JE" EXACT [] synonym: "platelet-derived growth factor-inducible protein JE" EXACT [] synonym: "SCYA2" RELATED [] synonym: "small-inducible cytokine A2" EXACT [] is_a: PR:000002038 ! eotaxin-like cytokine [Term] id: PR:000002125 name: C-C motif chemokine 7 def: "An eotaxin-like cytokine that is a translation product of the human CCL7 gene or a 1:1 ortholog thereof." [] synonym: "CCL7" EXACT [] synonym: "Fic" RELATED [] synonym: "intercrine/chemokine MARC" EXACT [] synonym: "MCP-3" EXACT [] synonym: "MCP3" RELATED [] synonym: "monocyte chemoattractant protein 3" EXACT [] synonym: "monocyte chemotactic protein 3" EXACT [] synonym: "NC28" EXACT [] synonym: "protein FIC" EXACT [] synonym: "SCYA6" RELATED [] synonym: "SCYA7" RELATED [] synonym: "small-inducible cytokine A7" EXACT [] is_a: PR:000002038 ! eotaxin-like cytokine [Term] id: PR:000002190 name: RAC-alpha serine/threonine-protein kinase def: "An AKT kinase that is a translation product of the human AKT1 gene or a 1:1 ortholog thereof." [] synonym: "Akt" RELATED [] synonym: "AKT1" EXACT [] synonym: "AKT1 kinase" EXACT [] synonym: "PKB" BROAD [] synonym: "PKB alpha" EXACT [] synonym: "protein kinase B" EXACT [] synonym: "protein kinase B alpha" EXACT [] synonym: "proto-oncogene c-Akt" EXACT [] synonym: "RAC" RELATED [] synonym: "RAC-PK-alpha" EXACT [] synonym: "thymoma viral proto-oncogene" EXACT [] is_a: PR:000029189 ! AKT kinase [Term] id: PR:000002198 name: catenin beta-1 def: "A protein that is a translation product of the human CTNNB1 gene or a 1:1 ortholog thereof." [] synonym: "beta-catenin" EXACT [] synonym: "Catnb" RELATED [] synonym: "CTNNB" RELATED [] synonym: "CTNNB1" EXACT [] synonym: "OK/SW-cl.35" RELATED [] synonym: "PRO2286" RELATED [] is_a: PR:000000001 ! protein [Term] id: PR:000002201 name: dynein light chain def: "A protein that is a translation product of the human DYNLL1 or DYNLL2 genes, or 1:1 orthologs thereof. The protein is small (89 residues in human and mouse) with core architecture consisting of a Dynein light chain type 1 domain (Pfam:PF01221)." [] is_a: PR:000000001 ! protein [Term] id: PR:000002204 name: lymphotoxin-alpha def: "A lymphotoxin that is a translation product of the human LTA gene or a 1:1 ortholog thereof." [] synonym: "LT-alpha" EXACT [] synonym: "LTA" EXACT [] synonym: "TNF-beta" EXACT [] synonym: "TNFB" RELATED [] synonym: "TNFSF1" RELATED [] synonym: "tumor necrosis factor B" EXACT [] synonym: "tumor necrosis factor ligand superfamily member 1" EXACT [] is_a: PR:000050043 ! lymphotoxin [Term] id: PR:000003035 name: cellular tumor antigen p53 def: "A protein that is a translation product of the human TP53 gene or a 1:1 ortholog thereof." [] synonym: "antigen NY-CO-13" EXACT [] synonym: "P53" RELATED [] synonym: "phosphoprotein p53" EXACT [] synonym: "TP53" EXACT [] synonym: "Trp53" RELATED [] synonym: "tumor suppressor p53" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000003112 name: NFAT protein def: "A protein that contains a Rel homology domain (RHD) (Pfam:PF00554) followed by an IPT/TIG domain (Pfam:PF01833)." [] is_a: PR:000000001 ! protein [Term] id: PR:000003113 name: nuclear factor of activated T-cells, cytoplasmic 1 def: "An NFAT protein that is a translation product of the human NFATC1 gene or a 1:1 ortholog thereof." [] synonym: "NF-ATc" EXACT [] synonym: "NF-ATc1" EXACT [] synonym: "NFAT transcription complex cytosolic component" EXACT [] synonym: "NFAT2" RELATED [] synonym: "NFATC" RELATED [] synonym: "NFATc" EXACT [] synonym: "NFATC1" EXACT [] synonym: "NFATc1" EXACT [] is_a: PR:000003112 ! NFAT protein [Term] id: PR:000003237 name: 14-3-3 protein def: "A protein that is a stand alone version of the 14-3-3 protein (Pfam:PF00244) domain." [] synonym: "fam:14-3-3" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000003425 name: Hsp70 family chaperone def: "A protein that is a stand alone version of the Hsp70 protein (Pfam:PF00012) domain, which comprises two major regions: an N-terminal ATP-binding domain and a C-terminal substrate-binding domain." [] is_a: PR:000000001 ! protein [Term] id: PR:000003652 name: acrosin def: "A protein that is a translation product of the human ACR gene or a 1:1 ortholog thereof." [] synonym: "ACR" EXACT [] synonym: "ACRS" RELATED [] is_a: PR:000000001 ! protein [Term] id: PR:000003761 name: pituitary adenylate cyclase-activating polypeptide def: "A protein that is a translation product of the human ADCYAP1 gene or a 1:1 ortholog thereof." [] synonym: "ADCYAP1" EXACT [] synonym: "PACAP" RELATED [] is_a: PR:000000001 ! protein [Term] id: PR:000003777 name: adiponectin def: "A protein that is a translation product of the human ADIPOQ gene or a 1:1 ortholog thereof." [] synonym: "30 kDa adipocyte complement-related protein" EXACT [] synonym: "ACDC" RELATED [] synonym: "ACRP30" RELATED [] synonym: "adipocyte complement-related 30 kDa protein" EXACT [] synonym: "adipocyte, C1q and collagen domain-containing protein" EXACT [] synonym: "adipocyte-specific protein AdipoQ" EXACT [] synonym: "ADIPOQ" EXACT [] synonym: "adipose most abundant gene transcript 1 protein" EXACT [] synonym: "apM-1" EXACT [] synonym: "APM1" RELATED [] synonym: "GBP28" RELATED [] synonym: "gelatin-binding protein" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000003858 name: aryl hydrocarbon receptor def: "A protein that is a translation product of the human AHR gene or a 1:1 ortholog thereof." [] synonym: "Ah receptor" EXACT [] synonym: "AHR" EXACT [] synonym: "AhR" EXACT [] synonym: "BHLHE76" RELATED [] synonym: "bHLHe76" EXACT [] synonym: "class E basic helix-loop-helix protein 76" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000004135 name: apelin def: "A protein that is a translation product of the human APLN gene or a 1:1 ortholog thereof." [] synonym: "APEL" RELATED [] synonym: "APJ endogenous ligand" EXACT [] synonym: "APLN" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000004140 name: apolipoprotein A-I def: "A protein that is a translation product of the human APOA1 gene or a 1:1 ortholog thereof." [] synonym: "apo-AI" EXACT [] synonym: "ApoA-I" EXACT [] synonym: "APOA1" EXACT [] synonym: "apolipoprotein A1" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000004168 name: amyloid-beta precursor protein def: "A protein that is a translation product of the human APP gene or a 1:1 ortholog thereof." [] synonym: "A4" RELATED [] synonym: "ABPP" EXACT [] synonym: "AD1" RELATED [] synonym: "AG" EXACT [] synonym: "alzheimer disease amyloid A4 protein homolog" EXACT [] synonym: "alzheimer disease amyloid protein" EXACT [] synonym: "amyloid beta A4 protein" EXACT [] synonym: "amyloid precursor protein" EXACT [] synonym: "amyloid-beta (A4) precursor protein" EXACT [] synonym: "amyloid-beta A4 protein" EXACT [] synonym: "amyloidogenic glycoprotein" EXACT [] synonym: "APP" EXACT [] synonym: "APPI" EXACT [] synonym: "cerebral vascular amyloid peptide" EXACT [] synonym: "CVAP" EXACT [] synonym: "PN-II" EXACT [] synonym: "PreA4" EXACT [] synonym: "protease nexin-II" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000004191 name: androgen receptor def: "A protein that is a translation product of the human AR gene or a 1:1 ortholog thereof." [] synonym: "AR" EXACT [] synonym: "DHTR" RELATED [] synonym: "dihydrotestosterone receptor" EXACT [] synonym: "NR3C4" RELATED [] synonym: "nuclear receptor subfamily 3 group C member 4" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000004580 name: beta-2-microglobulin def: "A protein that is a translation product of the human B2M gene or a 1:1 ortholog thereof." [] synonym: "B2M" EXACT [] synonym: "CDABP0092" RELATED [] synonym: "HDCMA22P" RELATED [] is_a: PR:000000001 ! protein [Term] id: PR:000004716 name: brain-derived neurotrophic factor def: "A neurotrophin that is a translation product of the human BDNF gene or a 1:1 ortholog thereof." [] synonym: "abrineurin" EXACT [] synonym: "BDNF" EXACT [] is_a: PR:000021998 ! neurotrophin [Term] id: PR:000004972 name: calcitonin receptor def: "A calcitonin receptor protein that is a translation product of the human CALCR gene or a 1:1 ortholog thereof." [] synonym: "CALCR" EXACT [] synonym: "CT-R" EXACT [] is_a: PR:000044637 ! calcitonin receptor protein [Term] id: PR:000004978 name: calmodulin def: "A protein that is a translation product of the human CALM1, CALM2, or CALM3 genes, 1:1 orthologs thereof, or a semi-ortholog thereof." [] synonym: "CALM" EXACT [] synonym: "CALML2" RELATED [] synonym: "CaM" EXACT [] synonym: "CAM3" NARROW [] synonym: "CAMC" RELATED [] synonym: "CAMIII" RELATED [] is_a: PR:000000001 ! protein [Term] id: PR:000005110 name: cholecystokinin def: "A protein that is a translation product of the human CCK gene or a 1:1 ortholog thereof." [] synonym: "CCK" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000005388 name: glycoprotein hormones alpha chain def: "A protein that is a translation product of the human CGA gene or a 1:1 ortholog thereof." [] synonym: "anterior pituitary glycoprotein hormones common subunit alpha" EXACT [] synonym: "CG-alpha" EXACT [] synonym: "CGA" EXACT [] synonym: "choriogonadotropin alpha chain" EXACT [] synonym: "chorionic gonadotrophin subunit alpha" EXACT [] synonym: "follicle-stimulating hormone alpha chain" EXACT [] synonym: "follitropin alpha chain" EXACT [] synonym: "FSH-alpha" EXACT [] synonym: "LSH-alpha" EXACT [] synonym: "luteinizing hormone alpha chain" EXACT [] synonym: "lutropin alpha chain" EXACT [] synonym: "thyroid-stimulating hormone alpha chain" EXACT [] synonym: "thyrotropin alpha chain" EXACT [] synonym: "TSH-alpha" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000005663 name: ciliary neurotrophic factor def: "A protein that is a translation product of the human CNTF gene or a 1:1 ortholog thereof." [] synonym: "CNTF" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000005869 name: corticotropin-releasing factor receptor 1 def: "A corticotropin-releasing factor receptor that is a translation product of the human CRHR1 gene or a 1:1 ortholog thereof." [] synonym: "corticotropin-releasing hormone receptor 1" EXACT [] synonym: "CRF-R-1" EXACT [] synonym: "CRF-R1" EXACT [] synonym: "CRFR" RELATED [] synonym: "CRFR-1" EXACT [] synonym: "CRFR1" RELATED [] synonym: "CRH-R-1" EXACT [] synonym: "CRH-R1" EXACT [] synonym: "CRHR" RELATED [] synonym: "CRHR1" EXACT [] is_a: PR:000044630 ! corticotropin-releasing factor receptor [Term] id: PR:000005870 name: corticotropin-releasing factor receptor 2 def: "A corticotropin-releasing factor receptor that is a translation product of the human CRHR2 gene or a 1:1 ortholog thereof." [] synonym: "corticotropin-releasing hormone receptor 2" EXACT [] synonym: "CRF-R-2" EXACT [] synonym: "CRF-R2" EXACT [] synonym: "CRF-RB" EXACT [] synonym: "CRF2R" RELATED [] synonym: "CRFR-2" EXACT [] synonym: "CRH-R-2" EXACT [] synonym: "CRH-R2" EXACT [] synonym: "CRH2R" RELATED [] synonym: "CRHR2" EXACT [] is_a: PR:000044630 ! corticotropin-releasing factor receptor [Term] id: PR:000005931 name: granulocyte-macrophage colony-stimulating factor def: "A protein that is a translation product of the human CSF2 gene or a 1:1 ortholog thereof." [] synonym: "colony-stimulating factor" EXACT [] synonym: "CSF" EXACT [] synonym: "CSF2" EXACT [] synonym: "Csfgm" RELATED [] synonym: "GM-CSF" EXACT [] synonym: "GMCSF" RELATED [] synonym: "molgramostin" EXACT [] synonym: "sargramostim" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000005932 name: granulocyte colony-stimulating factor def: "A protein that is a translation product of the human CSF3 gene or a 1:1 ortholog thereof." [] synonym: "C17orf33" RELATED [] synonym: "CSF3" EXACT [] synonym: "Csfg" RELATED [] synonym: "filgrastim" EXACT [] synonym: "G-CSF" EXACT [] synonym: "GCSF" RELATED [] synonym: "lenograstim" EXACT [] synonym: "pluripoietin" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000006013 name: catenin delta-2 def: "A protein that is a translation product of the human CTNND2 gene or a 1:1 ortholog thereof." [] synonym: "Catnd2" RELATED [] synonym: "CTNND2" EXACT [] synonym: "delta-catenin" EXACT [] synonym: "GT24" EXACT [] synonym: "neural plakophilin-related ARM-repeat protein" EXACT [] synonym: "neurojungin" EXACT [] synonym: "NPRAP" RELATED [] is_a: PR:000000001 ! protein [Term] id: PR:000006165 name: C-C motif chemokine 12 def: "An eotaxin-like cytokine that is a translation product of the mouse Ccl12 gene or a 1:1 ortholog thereof." [] synonym: "Ccl12" EXACT [] synonym: "MCP-1-related chemokine" EXACT [] synonym: "MCP-5" BROAD [] synonym: "Mcp5" RELATED [] synonym: "monocyte chemoattractant protein 5" EXACT [] synonym: "monocyte chemotactic protein 5" EXACT [] synonym: "Scya12" RELATED [] synonym: "small-inducible cytokine A12" EXACT [] is_a: PR:000002038 ! eotaxin-like cytokine [Term] id: PR:000006267 name: dystroglycan 1 def: "A protein that is a translation product of the human DAG1 gene or a 1:1 ortholog thereof." [] synonym: "Dag-1" RELATED [] synonym: "DAG1" EXACT [] synonym: "dystroglycan" EXACT [] synonym: "dystrophin-associated glycoprotein 1" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000006909 name: elongation factor 2 def: "A protein that is a translation product of the human EEF2 gene or a 1:1 ortholog thereof." [] synonym: "EEF2" EXACT [] synonym: "EF-2" EXACT [] synonym: "EF2" RELATED [] is_a: PR:000000001 ! protein [Term] id: PR:000006928 name: pro-epidermal growth factor def: "A protein that is a translation product of the human EGF gene or a 1:1 ortholog thereof." [] synonym: "EGF" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000006933 name: epidermal growth factor receptor def: "An EGF receptor type tyrosine-protein kinase that is a translation product of the human EGFR gene or a 1:1 ortholog thereof." [] synonym: "EGFR" EXACT [] synonym: "ERBB" RELATED [] synonym: "ERBB1" RELATED [] synonym: "HER1" RELATED [] synonym: "proto-oncogene c-ErbB-1" EXACT [] synonym: "receptor tyrosine-protein kinase erbB-1" EXACT [] is_a: PR:000001812 ! EGF receptor type tyrosine-protein kinase [Term] id: PR:000006990 name: eukaryotic translation initiation factor 4E def: "A protein that is a translation product of the human EIF4E gene or a 1:1 ortholog thereof." [] synonym: "eIF-4E" EXACT [] synonym: "eIF-4F 25 kDa subunit" EXACT [] synonym: "EIF4E" EXACT [] synonym: "eIF4E" EXACT [] synonym: "EIF4EL1" RELATED [] synonym: "EIF4F" RELATED [] synonym: "mRNA cap-binding protein" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000007141 name: erythropoietin def: "A protein that is a translation product of the human EPO gene or a 1:1 ortholog thereof." [] synonym: "EPO" EXACT [] synonym: "epoetin" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000007142 name: erythropoietin receptor def: "A protein that is a translation product of the human EPOR gene or a 1:1 ortholog thereof." [] synonym: "EPO-R" EXACT [] synonym: "EPOR" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000007204 name: estrogen receptor def: "A protein that is a translation product of the human ESR1 gene or a 1:1 ortholog thereof." [] synonym: "ER" EXACT [] synonym: "ER-alpha" EXACT [] synonym: "ESR" RELATED [] synonym: "ESR1" EXACT [] synonym: "Estr" RELATED [] synonym: "Estra" RELATED [] synonym: "estradiol receptor" EXACT [] synonym: "NR3A1" RELATED [] synonym: "nuclear receptor subfamily 3 group A member 1" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000007494 name: fibroblast growth factor 3 def: "A protein that is a translation product of the human FGF3 gene or a 1:1 ortholog thereof." [] synonym: "FGF-3" EXACT [] synonym: "FGF3" EXACT [] synonym: "HBGF-3" EXACT [] synonym: "heparin-binding growth factor 3" EXACT [] synonym: "Int-2" RELATED [] synonym: "INT-2 proto-oncogene protein" EXACT [] synonym: "INT2" RELATED [] synonym: "proto-oncogene Int-2" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000007495 name: fibroblast growth factor 4 def: "A protein that is a translation product of the human FGF4 gene or a 1:1 ortholog thereof." [] synonym: "FGF-4" EXACT [] synonym: "FGF4" EXACT [] synonym: "HBGF-4" EXACT [] synonym: "heparin secretory-transforming protein 1" EXACT [] synonym: "heparin-binding growth factor 4" EXACT [] synonym: "HST" BROAD [] synonym: "HST-1" EXACT [] synonym: "HSTF-1" EXACT [] synonym: "HSTF1" RELATED [] synonym: "K-fibroblast growth factor" EXACT [] synonym: "Kfgf" RELATED [] synonym: "KS3" RELATED [] synonym: "transforming protein KS3" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000007496 name: fibroblast growth factor 5 def: "A protein that is a translation product of the human FGF5 gene or a 1:1 ortholog thereof." [] synonym: "FGF-5" EXACT [] synonym: "FGF5" EXACT [] synonym: "HBGF-5" EXACT [] synonym: "heparin-binding growth factor 5" EXACT [] synonym: "Smag-82" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000007497 name: fibroblast growth factor 6 def: "A protein that is a translation product of the human FGF6 gene or a 1:1 ortholog thereof." [] synonym: "FGF-6" EXACT [] synonym: "FGF6" EXACT [] synonym: "HBGF-6" EXACT [] synonym: "heparin secretory-transforming protein 2" EXACT [] synonym: "heparin-binding growth factor 6" EXACT [] synonym: "HST-2" EXACT [] synonym: "HST2" RELATED [] synonym: "HSTF-2" EXACT [] synonym: "HSTF2" RELATED [] is_a: PR:000000001 ! protein [Term] id: PR:000007555 name: filamin-A def: "A protein that is a translation product of the human FLNA gene or a 1:1 ortholog thereof." [] synonym: "ABP-280" EXACT [] synonym: "actin-binding protein 280" EXACT [] synonym: "alpha-filamin" EXACT [] synonym: "endothelial actin-binding protein" EXACT [] synonym: "filamin-1" EXACT [] synonym: "FLN" RELATED [] synonym: "FLN-A" EXACT [] synonym: "FLN1" RELATED [] synonym: "FLNA" EXACT [] synonym: "non-muscle filamin" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000007556 name: filamin-B def: "A protein that is a translation product of the human FLNB gene or a 1:1 ortholog thereof." [] synonym: "ABP-278" EXACT [] synonym: "ABP-280 homolog" EXACT [] synonym: "ABP-280-like protein" RELATED [] synonym: "actin-binding-like protein" BROAD [] synonym: "beta-filamin" EXACT [] synonym: "Fh1" EXACT [] synonym: "filamin homolog 1" EXACT [] synonym: "filamin-3" EXACT [] synonym: "FLN-B" EXACT [] synonym: "FLN1L" RELATED [] synonym: "FLN3" RELATED [] synonym: "FLNB" EXACT [] synonym: "TABP" RELATED [] synonym: "TAP" RELATED [] synonym: "thyroid autoantigen" EXACT [] synonym: "truncated ABP" EXACT [] synonym: "truncated actin-binding protein" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000007557 name: filamin-C def: "A protein that is a translation product of the human FLNC gene or a 1:1 ortholog thereof." [] synonym: "ABP-280-like protein" RELATED [] synonym: "ABP-L" EXACT [] synonym: "ABPL" RELATED [] synonym: "actin-binding-like protein" BROAD [] synonym: "filamin-2" EXACT [] synonym: "FLN-C" EXACT [] synonym: "FLN2" RELATED [] synonym: "FLNC" EXACT [] synonym: "FLNc" EXACT [] synonym: "gamma-filamin" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000007563 name: vascular endothelial growth factor receptor 1 def: "A vascular endothelial growth factor receptor that is a translation product of the human FLT1 gene or a 1:1 ortholog thereof." [] synonym: "embryonic receptor kinase 2" EXACT [] synonym: "Emrk2" RELATED [] synonym: "FLT" RELATED [] synonym: "FLT-1" EXACT [] synonym: "FLT1" EXACT [] synonym: "Fms-like tyrosine kinase 1" EXACT [] synonym: "FRT" RELATED [] synonym: "tyrosine-protein kinase FRT" EXACT [] synonym: "tyrosine-protein kinase receptor FLT" EXACT [] synonym: "vascular permeability factor receptor" EXACT [] synonym: "VEGFR-1" EXACT [] synonym: "VEGFR1" RELATED [] is_a: PR:000001971 ! vascular endothelial growth factor receptor [Term] id: PR:000007565 name: vascular endothelial growth factor receptor 3 def: "A vascular endothelial growth factor receptor that is a translation product of the human FLT4 gene or a 1:1 ortholog thereof." [] synonym: "FLT-4" EXACT [] synonym: "FLT4" EXACT [] synonym: "Fms-like tyrosine kinase 4" EXACT [] synonym: "tyrosine-protein kinase receptor FLT4" EXACT [] synonym: "VEGFR-3" EXACT [] synonym: "VEGFR3" RELATED [] is_a: PR:000001971 ! vascular endothelial growth factor receptor [Term] id: PR:000007581 name: fibronectin def: "A protein that is a translation product of the human FN1 gene or a 1:1 ortholog thereof." [] synonym: "CIG" EXACT [] synonym: "cold-insoluble globulin" EXACT [] synonym: "FN" RELATED [] synonym: "FN1" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000007806 name: galanin def: "A protein that is a translation product of the human GAL gene or a 1:1 ortholog thereof." [] synonym: "GAL" EXACT [] synonym: "GAL1" RELATED [] synonym: "GALN" RELATED [] synonym: "GLNN" RELATED [] is_a: PR:000000001 ! protein [Term] id: PR:000007856 name: gastrin def: "A protein that is a translation product of the human GAST gene or a 1:1 ortholog thereof." [] synonym: "GAS" RELATED [] synonym: "GAST" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000007892 name: glucagon receptor def: "A glucagon-like receptor that is a translation product of the human GCGR gene or a 1:1 ortholog thereof." [] synonym: "GCGR" EXACT [] synonym: "GL-R" EXACT [] is_a: PR:000049989 ! glucagon-like receptor [Term] id: PR:000007893 name: GTP cyclohydrolase 1 def: "A protein that is a translation product of the human GCH1 gene or a 1:1 ortholog thereof." [] synonym: "DYT5" RELATED [] synonym: "GCH" RELATED [] synonym: "GCH1" EXACT [] synonym: "GTP cyclohydrolase I" BROAD [] synonym: "GTP-CH-I" BROAD [] is_a: PR:000000001 ! protein [Term] id: PR:000007928 name: glial cell line-derived neurotrophic factor def: "A protein that is a translation product of the human GDNF gene or a 1:1 ortholog thereof." [] synonym: "astrocyte-derived trophic factor" EXACT [] synonym: "ATF" EXACT [] synonym: "GDNF" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000007970 name: growth hormone receptor def: "A protein that is a translation product of the human GHR gene or a 1:1 ortholog thereof." [] synonym: "GH receptor" EXACT [] synonym: "GHR" EXACT [] synonym: "somatotropin receptor" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000007971 name: somatoliberin def: "A protein that is a translation product of the human GHRH gene or a 1:1 ortholog thereof." [] synonym: "GHRF" RELATED [] synonym: "GHRH" EXACT [] synonym: "GRF" EXACT [] synonym: "growth hormone-releasing factor" EXACT [] synonym: "growth hormone-releasing hormone" EXACT [] synonym: "sermorelin" EXACT [] synonym: "somatocrinin" EXACT [] synonym: "somatorelin" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000007972 name: growth hormone-releasing hormone receptor def: "A glucagon-like receptor that is a translation product of the human GHRHR gene or a 1:1 ortholog thereof." [] synonym: "GHRH receptor" EXACT [] synonym: "GHRHR" EXACT [] synonym: "GRF receptor" EXACT [] synonym: "GRFR" EXACT [] synonym: "growth hormone-releasing factor receptor" EXACT [] is_a: PR:000049989 ! glucagon-like receptor [Term] id: PR:000007973 name: appetite-regulating hormone def: "A protein that is a translation product of the human GHRL gene or a 1:1 ortholog thereof." [] synonym: "GHRL" EXACT [] synonym: "growth hormone secretagogue" EXACT [] synonym: "growth hormone-releasing peptide" EXACT [] synonym: "motilin-related peptide" EXACT [] synonym: "MTLRP" RELATED [] synonym: "protein M46" EXACT [] synonym: "UNQ524/PRO1066" RELATED [] is_a: PR:000000001 ! protein [Term] id: PR:000007988 name: gastric inhibitory polypeptide receptor def: "A glucagon-like receptor that is a translation product of the human GIPR gene or a 1:1 ortholog thereof." [] synonym: "GIP-R" EXACT [] synonym: "GIPR" EXACT [] synonym: "glucose-dependent insulinotropic polypeptide receptor" EXACT [] is_a: PR:000049989 ! glucagon-like receptor [Term] id: PR:000008476 name: hypocretin neuropeptide precursor def: "A protein that is a translation product of the human HCRT gene or a 1:1 ortholog thereof." [] synonym: "HCRT" EXACT [] synonym: "Hcrt" EXACT [] synonym: "hypocretin" EXACT [] synonym: "orexin" EXACT [] synonym: "orexin precursor" EXACT [] synonym: "OX" RELATED [] synonym: "PPORX" RELATED [] synonym: "PPOX" RELATED [] synonym: "prepro-orexin" EXACT [] synonym: "preprohypocretin" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000008534 name: hepatocyte growth factor def: "A protein that is a translation product of the human HGF gene or a 1:1 ortholog thereof." [] synonym: "hepatopoeitin-A" EXACT [] synonym: "hepatopoietin-A" EXACT [] synonym: "HGF" EXACT [] synonym: "HPTA" RELATED [] synonym: "scatter factor" EXACT [] synonym: "SF" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000008630 name: high mobility group protein B1 def: "A protein that is a translation product of the human HMGB1 gene or a 1:1 ortholog thereof." [] synonym: "high mobility group protein 1" EXACT [] synonym: "HMG-1" EXACT [] synonym: "HMG1" RELATED [] synonym: "HMGB1" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000008636 name: 3-hydroxy-3-methylglutaryl-coenzyme A reductase def: "A protein that is a translation product of the human HMGCR gene or a 1:1 ortholog thereof." [] synonym: "HMG-CoA reductase" EXACT [] synonym: "HMGCR" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000008725 name: haptoglobin def: "A protein that is a translation product of the human HP gene or a 1:1 ortholog thereof." [] synonym: "HP" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000008875 name: islet amyloid polypeptide def: "A protein that is a translation product of the human IAPP gene or a 1:1 ortholog thereof." [] synonym: "amylin" EXACT [] synonym: "DAP" BROAD [] synonym: "diabetes-associated peptide" EXACT [] synonym: "IAPP" EXACT [] synonym: "insulinoma amyloid peptide" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000008878 name: bone sialoprotein 2 def: "A protein that is a translation product of the human IBSP gene or a 1:1 ortholog thereof." [] synonym: "BNSP" RELATED [] synonym: "bone sialoprotein II" EXACT [] synonym: "BSP II" EXACT [] synonym: "cell-binding sialoprotein" EXACT [] synonym: "IBSP" EXACT [] synonym: "integrin-binding sialoprotein" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000008888 name: isocitrate dehydrogenase [NADP], mitochondrial def: "A protein that is a translation product of the human IDH2 gene or a 1:1 ortholog thereof." [] synonym: "ICD-M" EXACT [] synonym: "IDH" BROAD [] synonym: "IDH2" RELATED [] synonym: "IDH2nadp" EXACT [] synonym: "IDP" BROAD [] synonym: "NADP(+)-specific ICDH" BROAD [] synonym: "oxalosuccinate decarboxylase" BROAD [] is_a: PR:000000001 ! protein [Term] id: PR:000008910 name: interferon-induced helicase C domain-containing protein 1 def: "A protein that is a translation product of the human IFIH1 gene or a 1:1 ortholog thereof." [] synonym: "helicard" EXACT [] synonym: "helicase with 2 CARD domains" EXACT [] synonym: "IFIH1" EXACT [] synonym: "interferon induced with helicase C domain protein 1" EXACT [] synonym: "interferon-induced with helicase C domain protein 1" EXACT [] synonym: "MDA-5" EXACT [] synonym: "MDA5" RELATED [] synonym: "melanoma differentiation-associated protein 5" EXACT [] synonym: "murabutide down-regulated protein" EXACT [] synonym: "RH116" RELATED [] synonym: "RIG-I-like receptor 2" EXACT [] synonym: "RLR-2" EXACT [] synonym: "RNA helicase-DEAD box protein 116" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000008942 name: insulin-like growth factor II def: "A protein that is a translation product of the human IGF2 gene or a 1:1 ortholog thereof." [] synonym: "Igf-2" RELATED [] synonym: "IGF-II" EXACT [] synonym: "IGF2" EXACT [] synonym: "multiplication-stimulating polypeptide" EXACT [] synonym: "PP1446" RELATED [] synonym: "somatomedin-A" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000008998 name: interleukin-21 receptor def: "A protein that is a translation product of the human IL21R gene or a 1:1 ortholog thereof." [] synonym: "CD360" EXACT [] synonym: "IL-21 receptor" EXACT [] synonym: "IL-21R" EXACT [] synonym: "IL21R" EXACT [] synonym: "LR-beta" EXACT [] synonym: "lymphocyte receptor beta" EXACT [] synonym: "NILR" RELATED [] synonym: "novel cytokine receptor 8" EXACT [] synonym: "novel interleukin receptor" EXACT [] synonym: "NR8" EXACT [] synonym: "UNQ3121/PRO10273" RELATED [] is_a: PR:000000001 ! protein [Term] id: PR:000009001 name: interleukin-23 receptor def: "A protein that is a translation product of the human IL23R gene or a 1:1 ortholog thereof." [] synonym: "IL-23 receptor" EXACT [] synonym: "IL-23R" EXACT [] synonym: "IL23R" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000009054 name: insulin gene translation product def: "An insulin family protein that is a translation product of the human INS gene or a 1:1 ortholog thereof." [] synonym: "INS" EXACT [] synonym: "insulin" BROAD [] is_a: PR:000045358 ! insulin family protein [Term] id: PR:000009064 name: insulin receptor def: "A protein that is a translation product of the human INSR gene or a 1:1 ortholog thereof." [] synonym: "CD220" EXACT [] synonym: "INSR" EXACT [] synonym: "IR" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000009182 name: insulin-like growth factor I def: "A protein that is a translation product of the human IGF1 gene or a 1:1 ortholog thereof." [] synonym: "IBP1" RELATED [] synonym: "Igf-1" RELATED [] synonym: "IGF-I" BROAD [] synonym: "IGF1" EXACT [] synonym: "mechano growth factor" EXACT [] synonym: "MGF" BROAD [] synonym: "somatomedin" EXACT [] synonym: "somatomedin-C" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000009345 name: kit ligand def: "A protein that is a translation product of the human KITLG gene or a 1:1 ortholog thereof." [] synonym: "c-Kit ligand" EXACT [] synonym: "hematopoietic growth factor KL" EXACT [] synonym: "Kitl" RELATED [] synonym: "KITLG" EXACT [] synonym: "mast cell growth factor" RELATED [] synonym: "MGF" BROAD [] synonym: "SCF" RELATED [] synonym: "Sl" RELATED [] synonym: "Slf" RELATED [] synonym: "steel factor" EXACT [] synonym: "stem cell factor" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000009799 name: leukemia inhibitory factor def: "A protein that is a translation product of the human LIF gene or a 1:1 ortholog thereof." [] synonym: "D factor" EXACT [] synonym: "differentiation-stimulating factor" EXACT [] synonym: "emfilermin" EXACT [] synonym: "HILDA" RELATED [] synonym: "LIF" EXACT [] synonym: "melanoma-derived LPL inhibitor" EXACT [] synonym: "MLPLI" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000009978 name: lactotransferrin def: "A protein that is a translation product of the human LTF gene or a 1:1 ortholog thereof." [] synonym: "GIG12" RELATED [] synonym: "lactoferrin" EXACT [] synonym: "LF" RELATED [] synonym: "LTF" EXACT [] synonym: "talalactoferrin" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000010335 name: hepatocyte growth factor receptor def: "An HGF/MSP receptor type tyrosine-protein kinase that is a translation product of the human MET gene or a 1:1 ortholog thereof." [] synonym: "HGF receptor" EXACT [] synonym: "HGF/SF receptor" EXACT [] synonym: "MET" EXACT [] synonym: "proto-oncogene c-Met" EXACT [] synonym: "scatter factor receptor" EXACT [] synonym: "SF receptor" EXACT [] synonym: "tyrosine-protein kinase Met" EXACT [] is_a: PR:000001816 ! HGF/MSP receptor type tyrosine-protein kinase [Term] id: PR:000010413 name: macrophage migration inhibitory factor def: "A protein that is a translation product of the human MIF gene or a 1:1 ortholog thereof." [] synonym: "delayed early response protein 6" EXACT [] synonym: "DER6" EXACT [] synonym: "GIF" RELATED [] synonym: "GLIF" RELATED [] synonym: "glycosylation-inhibiting factor" EXACT [] synonym: "L-dopachrome isomerase" EXACT [] synonym: "L-dopachrome tautomerase" RELATED [] synonym: "MIF" EXACT [] synonym: "MMIF" RELATED [] synonym: "phenylpyruvate tautomerase" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000010444 name: mitogen-activated protein kinase kinase kinase 21 def: "A protein that is a translation product of the human MAP3K21 gene or a 1:1 ortholog thereof." [] synonym: "KIAA1804" RELATED [] synonym: "MAP3K21" EXACT [] synonym: "mitogen-activated protein kinase kinase kinase MLK4" EXACT [] synonym: "mixed lineage kinase 4" EXACT [] synonym: "MLK4" RELATED [] is_a: PR:000000001 ! protein [Term] id: PR:000010818 name: myogenic factor 5 def: "A protein that is a translation product of the human MYF5 gene or a 1:1 ortholog thereof." [] synonym: "BHLHC2" RELATED [] synonym: "bHLHc2" EXACT [] synonym: "class C basic helix-loop-helix protein 2" EXACT [] synonym: "Myf-5" RELATED [] synonym: "MYF5" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000010855 name: myosin-Ia def: "A protein that is a translation product of the human MYO1A gene or a 1:1 ortholog thereof." [] synonym: "BBM-I" EXACT [] synonym: "BBMI" EXACT [] synonym: "brush border myosin I" EXACT [] synonym: "MIHC" EXACT [] synonym: "MYHL" RELATED [] synonym: "MYO1A" EXACT [] synonym: "myosin I heavy chain" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000010877 name: myogenin def: "A protein that is a translation product of the human MYOG gene or a 1:1 ortholog thereof." [] synonym: "BHLHC3" RELATED [] synonym: "bHLHc3" EXACT [] synonym: "class C basic helix-loop-helix protein 3" EXACT [] synonym: "Myf-4" EXACT [] synonym: "MYF4" RELATED [] synonym: "MYOD1-related protein" EXACT [] synonym: "MYOG" EXACT [] synonym: "myogenic factor 4" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000010882 name: myozenin-1 def: "A protein that is a translation product of the human MYOZ1 gene or a 1:1 ortholog thereof." [] synonym: "calsarcin-2" EXACT [] synonym: "filamin-, actinin- and telethonin-binding protein" EXACT [] synonym: "MYOZ" RELATED [] synonym: "MYOZ1" EXACT [] synonym: "protein FATZ" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000011116 name: NEDD8 protein def: "A protein that is a translation product of the human NEDD8 gene or a 1:1 ortholog thereof." [] synonym: "NEDD-8" EXACT [] synonym: "NEDD8" EXACT [] synonym: "neddylin" EXACT [] synonym: "neural precursor cell expressed developmentally down-regulated protein 8" EXACT [] synonym: "ubiquitin-like protein Nedd8" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000011164 name: nuclear factor of activated T-cells, cytoplasmic 2 def: "A protein that is a translation product of the human NFATC2 gene or a 1:1 ortholog thereof." [] synonym: "NF-ATc2" EXACT [] synonym: "NF-ATp" EXACT [] synonym: "NFAT pre-existing subunit" EXACT [] synonym: "NFAT1" RELATED [] synonym: "NFATC2" EXACT [] synonym: "NFATc2" EXACT [] synonym: "NFATP" RELATED [] synonym: "T-cell transcription factor NFAT1" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000011166 name: nuclear factor of activated T-cells, cytoplasmic 3 def: "A protein that is a translation product of the human NFATC3 gene or a 1:1 ortholog thereof." [] synonym: "NF-AT4" EXACT [] synonym: "NF-ATc3" EXACT [] synonym: "NFAT4" RELATED [] synonym: "NFATC3" EXACT [] synonym: "NFATc3" EXACT [] synonym: "NFATx" EXACT [] synonym: "T-cell transcription factor NFAT4" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000011167 name: nuclear factor of activated T-cells, cytoplasmic 4 def: "A protein that is a translation product of the human NFATC4 gene or a 1:1 ortholog thereof." [] synonym: "NF-AT3" EXACT [] synonym: "NF-ATc4" EXACT [] synonym: "NFAT3" RELATED [] synonym: "NFATC4" EXACT [] synonym: "NFATc4" EXACT [] synonym: "T-cell transcription factor NFAT3" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000011194 name: beta-nerve growth factor def: "A neurotrophin that is a translation product of the human NGF gene or a 1:1 ortholog thereof." [] synonym: "beta-NGF" EXACT [] synonym: "NGF" EXACT [] synonym: "NGFB" RELATED [] is_a: PR:000021998 ! neurotrophin [Term] id: PR:000011374 name: atrial natriuretic factor def: "A protein that is a translation product of the human NPPA gene or a 1:1 ortholog thereof." [] synonym: "ANF" EXACT [] synonym: "ANP" RELATED [] synonym: "atrial natriuretic factor prohormone" EXACT [] synonym: "atrial natriuretic peptide" EXACT [] synonym: "atrial natriuretic peptide prohormone" EXACT [] synonym: "atriopeptigen" EXACT [] synonym: "cardiodilatin" EXACT [] synonym: "CDD" EXACT [] synonym: "CDD-ANF" EXACT [] synonym: "NPPA" EXACT [] synonym: "PND" RELATED [] synonym: "preproANP" EXACT [] synonym: "preproCDD-ANF" EXACT [] synonym: "prepronatriodilatin" EXACT [] synonym: "proANF" EXACT [] synonym: "proANP" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000011387 name: neuropeptide Y def: "A protein that is a translation product of the human NPY gene or a 1:1 ortholog thereof." [] synonym: "NPY" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000011406 name: glucocorticoid receptor def: "A protein that is a translation product of the human NR3C1 gene or a 1:1 ortholog thereof." [] synonym: "GR" RELATED [] synonym: "GRL" RELATED [] synonym: "Grl1" RELATED [] synonym: "NR3C1" EXACT [] synonym: "nuclear receptor subfamily 3 group C member 1" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000011407 name: mineralocorticoid receptor def: "A protein that is a translation product of the human NR3C2 gene or a 1:1 ortholog thereof." [] synonym: "MCR" RELATED [] synonym: "MLR" RELATED [] synonym: "MR" EXACT [] synonym: "NR3C2" EXACT [] synonym: "nuclear receptor subfamily 3 group C member 2" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000011459 name: neurotrophin-3 def: "A neurotrophin that is a translation product of the human NTF3 gene or a 1:1 ortholog thereof." [] synonym: "HDNF" EXACT [] synonym: "nerve growth factor 2" EXACT [] synonym: "neurotrophic factor" EXACT [] synonym: "NGF-2" EXACT [] synonym: "NT-3" EXACT [] synonym: "Ntf-3" RELATED [] synonym: "NTF3" EXACT [] is_a: PR:000021998 ! neurotrophin [Term] id: PR:000012059 name: oncostatin-M def: "A protein that is a translation product of the human OSM gene or a 1:1 ortholog thereof." [] synonym: "OSM" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000012421 name: proliferating cell nuclear antigen def: "A protein that is a translation product of the human PCNA gene or a 1:1 ortholog thereof." [] synonym: "cyclin" EXACT [] synonym: "PCNA" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000012621 name: progesterone receptor def: "A protein that is a translation product of the human PGR gene or a 1:1 ortholog thereof." [] synonym: "NR3C3" RELATED [] synonym: "nuclear receptor subfamily 3 group C member 3" EXACT [] synonym: "PGR" EXACT [] synonym: "PR" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000012705 name: polymeric immunoglobulin receptor def: "A protein that is a translation product of the human PIGR gene or a 1:1 ortholog thereof." [] synonym: "hepatocellular carcinoma-associated protein TB6" EXACT [] synonym: "PIGR" EXACT [] synonym: "PIgR" EXACT [] synonym: "poly-Ig receptor" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000012826 name: urokinase-type plasminogen activator def: "A protein that is a translation product of the human PLAU gene or a 1:1 ortholog thereof." [] synonym: "PLAU" EXACT [] synonym: "U-plasminogen activator" EXACT [] synonym: "uPA" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000013164 name: pancreatic prohormone def: "A protein that is a translation product of the human PPY gene or a 1:1 ortholog thereof." [] synonym: "obinepitide" EXACT [] synonym: "pancreatic polypeptide" EXACT [] synonym: "PNP" RELATED [] synonym: "PP" EXACT [] synonym: "PPY" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000013246 name: prolactin def: "A somatotropin hormone family member that is a translation product of the human PRL gene or a 1:1 ortholog thereof." [] synonym: "PRL" EXACT [] is_a: PR:000029968 ! somatotropin hormone family member [Term] id: PR:000013248 name: prolactin receptor def: "A protein that is a translation product of the human PRLR gene or a 1:1 ortholog thereof." [] synonym: "PRL-R" EXACT [] synonym: "PRLR" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000013429 name: parathyroid hormone def: "A protein that is a translation product of the human PTH gene or a 1:1 ortholog thereof." [] synonym: "parathormone" EXACT [] synonym: "parathyrin" EXACT [] synonym: "PTH" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000013526 name: peptide YY def: "A protein that is a translation product of the human PYY gene or a 1:1 ortholog thereof." [] synonym: "peptide tyrosine tyrosine" EXACT [] synonym: "PYY" EXACT [] synonym: "PYY-I" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000013743 name: Ras GTPase-activating protein 1 def: "A protein that is a translation product of the human RASA1 gene or a 1:1 ortholog thereof." [] synonym: "GAP" BROAD [] synonym: "GTPase-activating protein" EXACT [] synonym: "p120GAP" EXACT [] synonym: "ras p21 protein activator" EXACT [] synonym: "RASA" RELATED [] synonym: "RASA1" EXACT [] synonym: "RasGAP" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000013883 name: renin def: "An angiotensinogenase that is a translation product of the human REN gene or a 1:1 ortholog thereof." [] synonym: "angiotensinogenase" RELATED [] synonym: "REN" EXACT [] is_a: PR:000050025 ! angiotensinogenase [Term] id: PR:000014271 name: ubiquitin-40S ribosomal protein S27a def: "A protein that is a translation product of the human RPS27A gene or a 1:1 ortholog thereof." [] synonym: "40S ribosomal protein S27a" RELATED [] synonym: "RPS27A" EXACT [] synonym: "UBA80" RELATED [] synonym: "UBCEP1" RELATED [] synonym: "ubiquitin carboxyl extension protein 80" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000014543 name: secretin def: "A protein that is a translation product of the human SCT gene or a 1:1 ortholog thereof." [] synonym: "SCT" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000014544 name: secretin receptor def: "A glucagon-like receptor that is a translation product of the human SCTR gene or a 1:1 ortholog thereof." [] synonym: "SCT-R" EXACT [] synonym: "SCTR" EXACT [] is_a: PR:000049989 ! glucagon-like receptor [Term] id: PR:000014717 name: protein SET def: "A protein that is a translation product of the human SET gene or a 1:1 ortholog thereof." [] synonym: "HLA-DR-associated protein II" NARROW [] synonym: "I-2PP2A" EXACT [] synonym: "IGAAD" EXACT [] synonym: "inhibitor of granzyme A-activated DNase" EXACT [] synonym: "PHAPII" EXACT [] synonym: "phosphatase 2A inhibitor I2PP2A" EXACT [] synonym: "SET" EXACT [] synonym: "TAF-I" EXACT [] synonym: "template-activating factor I" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000015288 name: smoothened def: "A frizzled-like G-protein coupled receptor that is a translation product of the human SMO gene or a 1:1 ortholog thereof." [] synonym: "protein Gx" EXACT [] synonym: "SMO" EXACT [] synonym: "SMOH" RELATED [] is_a: PR:000001315 ! frizzled-like G-protein coupled receptor [Term] id: PR:000015794 name: syntaxin-2 def: "A protein that is a translation product of the human STX2 gene or a 1:1 ortholog thereof." [] synonym: "EPIM" RELATED [] synonym: "epimorphin" EXACT [] synonym: "STX2" EXACT [] synonym: "STX2A" RELATED [] synonym: "STX2B" RELATED [] synonym: "STX2C" RELATED [] is_a: PR:000000001 ! protein [Term] id: PR:000015795 name: syntaxin-3 def: "A protein that is a translation product of the human STX3 gene or a 1:1 ortholog thereof." [] synonym: "STX3" EXACT [] synonym: "STX3A" RELATED [] is_a: PR:000000001 ! protein [Term] id: PR:000015797 name: syntaxin-5 def: "A protein that is a translation product of the human STX5 gene or a 1:1 ortholog thereof." [] synonym: "STX5" EXACT [] synonym: "STX5A" RELATED [] is_a: PR:000000001 ! protein [Term] id: PR:000015798 name: syntaxin-6 def: "A protein that is a translation product of the human STX6 gene or a 1:1 ortholog thereof." [] synonym: "STX6" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000016051 name: antigen peptide transporter 1 def: "A protein that is a translation product of the human TAP1 gene or a 1:1 ortholog thereof." [] synonym: "ABCB2" RELATED [] synonym: "APT1" EXACT [] synonym: "ATP-binding cassette sub-family B member 2" EXACT [] synonym: "Ham-1" RELATED [] synonym: "Ham1" RELATED [] synonym: "histocompatibility antigen modifier 1" EXACT [] synonym: "peptide supply factor 1" EXACT [] synonym: "peptide transporter involved in antigen processing 1" EXACT [] synonym: "peptide transporter PSF1" EXACT [] synonym: "peptide transporter TAP1" EXACT [] synonym: "PSF-1" EXACT [] synonym: "PSF1" RELATED [] synonym: "really interesting new gene 4 protein" EXACT [] synonym: "RING4" RELATED [] synonym: "TAP1" EXACT [] synonym: "Y3" RELATED [] is_a: PR:000000001 ! protein [Term] id: PR:000016052 name: antigen peptide transporter 2 def: "A protein that is a translation product of the human TAP2 gene or a 1:1 ortholog thereof." [] synonym: "ABCB3" RELATED [] synonym: "APT2" EXACT [] synonym: "ATP-binding cassette sub-family B member 3" EXACT [] synonym: "Ham-2" RELATED [] synonym: "Ham2" RELATED [] synonym: "histocompatibility antigen modifier 2" EXACT [] synonym: "peptide supply factor 2" EXACT [] synonym: "peptide transporter involved in antigen processing 2" EXACT [] synonym: "peptide transporter PSF2" EXACT [] synonym: "peptide transporter TAP2" EXACT [] synonym: "PSF-2" EXACT [] synonym: "PSF2" RELATED [] synonym: "really interesting new gene 11 protein" EXACT [] synonym: "RING11" RELATED [] synonym: "TAP2" EXACT [] synonym: "Y1" RELATED [] is_a: PR:000000001 ! protein [Term] id: PR:000016053 name: tapasin def: "A protein that is a translation product of the human TAPBP gene or a 1:1 ortholog thereof." [] synonym: "NGS-17" EXACT [] synonym: "NGS17" RELATED [] synonym: "TAP-associated protein" EXACT [] synonym: "TAP-binding protein" EXACT [] synonym: "TAPA" RELATED [] synonym: "TAPBP" EXACT [] synonym: "TPN" EXACT [] synonym: "TPSN" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000016156 name: telethonin def: "A protein that is a translation product of the human TCAP gene or a 1:1 ortholog thereof." [] synonym: "TCAP" EXACT [] synonym: "titin cap protein" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000016261 name: serotransferrin def: "A protein that is a translation product of the human TF gene or a 1:1 ortholog thereof." [] synonym: "beta-1 metal-binding globulin" EXACT [] synonym: "PRO1400" RELATED [] synonym: "siderophilin" EXACT [] synonym: "TF" EXACT [] synonym: "transferrin" EXACT [] synonym: "Trf" RELATED [] is_a: PR:000000001 ! protein [Term] id: PR:000016301 name: tyrosine 3-monooxygenase def: "A protein that is a translation product of the human TH gene or a 1:1 ortholog thereof." [] synonym: "TH" EXACT [] synonym: "TYH" RELATED [] synonym: "tyrosine 3-hydroxylase" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000016542 name: type 1B DNA topoisomerase 1 def: "A protein that is a translation product of the human TOP1 gene or a 1:1 ortholog thereof." [] synonym: "DNA topoisomerase I" BROAD [] synonym: "Top-1" RELATED [] synonym: "TOP1" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000016724 name: thyrotropin subunit beta def: "A glycoprotein hormone beta chain that is a translation product of the human TSHB gene or a 1:1 ortholog thereof." [] synonym: "thyroid-stimulating hormone subunit beta" EXACT [] synonym: "thyrotropin alfa" EXACT [] synonym: "thyrotropin beta chain" EXACT [] synonym: "TSH-B" EXACT [] synonym: "TSH-beta" EXACT [] synonym: "TSHB" EXACT [] is_a: PR:000044813 ! glycoprotein hormone beta chain [Term] id: PR:000016798 name: titin def: "A protein that is a translation product of the human TTN gene or a 1:1 ortholog thereof." [] synonym: "connectin" EXACT [] synonym: "rhabdomyosarcoma antigen MU-RMS-40.14" EXACT [] synonym: "TTN" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000016954 name: ubiquitin-60S ribosomal protein L40 def: "A protein that is a translation product of the human UBA52 gene or a 1:1 ortholog thereof." [] synonym: "60S ribosomal protein L40" RELATED [] synonym: "CEP52" EXACT [] synonym: "UBA52" EXACT [] synonym: "UBCEP2" RELATED [] synonym: "ubiquitin A-52 residue ribosomal protein fusion product 1" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000016963 name: polyubiquitin-C def: "A tandem-copy polyubiquitin that is a translation product of the human UBC gene or a 1:1 ortholog thereof." [] synonym: "UBC" EXACT [] is_a: PR:000036929 ! tandem-copy polyubiquitin [Term] id: PR:000016964 name: ubiquitin D def: "A protein that is a translation product of the human UBD gene or a 1:1 ortholog thereof." [] synonym: "diubiquitin" EXACT [] synonym: "FAT10" RELATED [] synonym: "UBD" EXACT [] synonym: "ubiquitin-like protein FAT10" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000017272 name: vinculin def: "A protein that is a translation product of the human VCL gene or a 1:1 ortholog thereof." [] synonym: "metavinculin" EXACT [] synonym: "VCL" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000017283 name: vitamin D3 receptor def: "A protein that is a translation product of the human VDR gene or a 1:1 ortholog thereof." [] synonym: "1,25-dihydroxyvitamin D3 receptor" EXACT [] synonym: "NR1I1" RELATED [] synonym: "nuclear receptor subfamily 1 group I member 1" EXACT [] synonym: "VDR" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000018263 name: amino acid chain def: "An organic amino compound that consists of amino acid residues (unmodified amino-acid residues and/or modified amino-acid residues) linked by peptide bonds or derivatives of such bonds." [] synonym: "peptide" NARROW [] synonym: "polypeptide" NARROW [] is_a: CHEBI:50047 relationship: has_constituent_monomer CHEBI:33708 {minCardinality="2"} [Term] id: PR:000018264 name: proteolytic cleavage product def: "A protein that is produced as the result of proteolytic processing of a longer protein." [] synonym: "ClvPrd" EXACT [] synonym: "peptide" NARROW [] synonym: "polypeptide" NARROW [] is_a: PR:000000001 ! protein intersection_of: PR:000000001 ! protein intersection_of: output_of GO:0016485 relationship: output_of GO:0016485 [Term] id: PR:000018271 name: interferon gamma proteolytic cleavage product def: "An interferon gamma that has been processed by proteolytic cleavage." [] synonym: "IFNG/ClvPrd" EXACT [] is_a: PR:000000017 ! interferon gamma is_a: PR:000018264 ! proteolytic cleavage product intersection_of: PR:000000017 ! interferon gamma intersection_of: output_of GO:0016485 relationship: output_of GO:0016485 [Term] id: PR:000018435 name: interleukin-16 proteolytic cleavage product def: "An interleukin-16 that has been processed by proteolytic cleavage." [] synonym: "IL16/ClvPrd" EXACT [] is_a: PR:000001374 ! interleukin-16 is_a: PR:000018264 ! proteolytic cleavage product intersection_of: PR:000001374 ! interleukin-16 intersection_of: output_of GO:0016485 relationship: output_of GO:0016485 [Term] id: PR:000018438 name: interleukin-18 proteolytic cleavage product def: "An interleukin-18 that has been processed by proteolytic cleavage." [] synonym: "IL18/ClvPrd" EXACT [] is_a: PR:000001376 ! interleukin-18 is_a: PR:000018264 ! proteolytic cleavage product intersection_of: PR:000001376 ! interleukin-18 intersection_of: output_of GO:0016485 relationship: output_of GO:0016485 [Term] id: PR:000018461 name: interleukin-8 proteolytic cleavage product def: "An interleukin-8 that has been processed by proteolytic cleavage." [] synonym: "CXCL8/ClvPrd" EXACT [] is_a: PR:000001395 ! interleukin-8 is_a: PR:000018264 ! proteolytic cleavage product intersection_of: PR:000001395 ! interleukin-8 intersection_of: output_of GO:0016485 relationship: output_of GO:0016485 [Term] id: PR:000018513 name: proteinase-activated receptor 1 proteolytic cleavage product def: "A proteinase-activated receptor 1 that has been processed by proteolytic cleavage." [] synonym: "F2R/ClvPrd" EXACT [] is_a: PR:000001661 ! proteinase-activated receptor 1 is_a: PR:000018264 ! proteolytic cleavage product intersection_of: PR:000001661 ! proteinase-activated receptor 1 intersection_of: output_of GO:0016485 relationship: output_of GO:0016485 [Term] id: PR:000018718 name: C-C motif chemokine 5 proteolytic cleavage product def: "A C-C motif chemokine 5 that has been processed by proteolytic cleavage." [] synonym: "CCL5/ClvPrd" EXACT [] is_a: PR:000002094 ! C-C motif chemokine 5 is_a: PR:000018264 ! proteolytic cleavage product intersection_of: PR:000002094 ! C-C motif chemokine 5 intersection_of: output_of GO:0016485 relationship: output_of GO:0016485 [Term] id: PR:000018721 name: tumor necrosis factor ligand superfamily member 11 proteolytic cleavage product def: "A tumor necrosis factor ligand superfamily member 11 that has been processed by proteolytic cleavage." [] synonym: "TNFSF11/ClvPrd" EXACT [] is_a: PR:000002107 ! tumor necrosis factor ligand superfamily member 11 is_a: PR:000018264 ! proteolytic cleavage product intersection_of: PR:000002107 ! tumor necrosis factor ligand superfamily member 11 intersection_of: output_of GO:0016485 relationship: output_of GO:0016485 [Term] id: PR:000018880 name: acrosin proteolytic cleavage product def: "An acrosin that has been processed by proteolytic cleavage." [] synonym: "ACR/ClvPrd" EXACT [] is_a: PR:000003652 ! acrosin is_a: PR:000018264 ! proteolytic cleavage product intersection_of: PR:000003652 ! acrosin intersection_of: output_of GO:0016485 relationship: output_of GO:0016485 [Term] id: PR:000018902 name: pituitary adenylate cyclase-activating polypeptide proteolytic cleavage product def: "A pituitary adenylate cyclase-activating polypeptide that has been processed by proteolytic cleavage." [] synonym: "ADCYAP1/ClvPrd" EXACT [] is_a: PR:000003761 ! pituitary adenylate cyclase-activating polypeptide is_a: PR:000018264 ! proteolytic cleavage product intersection_of: PR:000003761 ! pituitary adenylate cyclase-activating polypeptide intersection_of: output_of GO:0016485 relationship: output_of GO:0016485 [Term] id: PR:000018934 name: aryl hydrocarbon receptor proteolytic cleavage product def: "An aryl hydrocarbon receptor that has been processed by proteolytic cleavage." [] synonym: "AHR/ClvPrd" EXACT [] is_a: PR:000003858 ! aryl hydrocarbon receptor is_a: PR:000018264 ! proteolytic cleavage product intersection_of: PR:000003858 ! aryl hydrocarbon receptor intersection_of: output_of GO:0016485 relationship: output_of GO:0016485 [Term] id: PR:000019010 name: apolipoprotein A-I proteolytic cleavage product def: "An apolipoprotein A-I that has been processed by proteolytic cleavage." [] synonym: "APOA1/ClvPrd" EXACT [] is_a: PR:000004140 ! apolipoprotein A-I is_a: PR:000018264 ! proteolytic cleavage product intersection_of: PR:000004140 ! apolipoprotein A-I intersection_of: output_of GO:0016485 relationship: output_of GO:0016485 [Term] id: PR:000019036 name: amyloid-beta precursor protein proteolytic cleavage product def: "An amyloid-beta precursor protein that has been processed by proteolytic cleavage." [] synonym: "APP/ClvPrd" EXACT [] is_a: PR:000004168 ! amyloid-beta precursor protein is_a: PR:000018264 ! proteolytic cleavage product intersection_of: PR:000004168 ! amyloid-beta precursor protein intersection_of: output_of GO:0016485 relationship: output_of GO:0016485 [Term] id: PR:000019110 name: beta-2-microglobulin proteolytic cleavage product def: "A beta-2-microglobulin that has been processed by proteolytic cleavage." [] synonym: "B2M/ClvPrd" EXACT [] is_a: PR:000004580 ! beta-2-microglobulin is_a: PR:000018264 ! proteolytic cleavage product intersection_of: PR:000004580 ! beta-2-microglobulin intersection_of: output_of GO:0016485 relationship: output_of GO:0016485 [Term] id: PR:000019130 name: brain-derived neurotrophic factor proteolytic cleavage product def: "A brain-derived neurotrophic factor that has been processed by proteolytic cleavage." [] synonym: "BDNF/ClvPrd" EXACT [] is_a: PR:000004716 ! brain-derived neurotrophic factor is_a: PR:000018264 ! proteolytic cleavage product intersection_of: PR:000004716 ! brain-derived neurotrophic factor intersection_of: output_of GO:0016485 relationship: output_of GO:0016485 [Term] id: PR:000019255 name: cholecystokinin proteolytic cleavage product def: "A cholecystokinin that has been processed by proteolytic cleavage." [] synonym: "CCK/ClvPrd" EXACT [] is_a: PR:000005110 ! cholecystokinin is_a: PR:000018264 ! proteolytic cleavage product intersection_of: PR:000005110 ! cholecystokinin intersection_of: output_of GO:0016485 relationship: output_of GO:0016485 [Term] id: PR:000019642 name: dystroglycan 1 proteolytic cleavage product def: "A dystroglycan 1 that has been processed by proteolytic cleavage." [] synonym: "DAG1/ClvPrd" EXACT [] is_a: PR:000006267 ! dystroglycan 1 is_a: PR:000018264 ! proteolytic cleavage product intersection_of: PR:000006267 ! dystroglycan 1 intersection_of: output_of GO:0016485 relationship: output_of GO:0016485 [Term] id: PR:000019751 name: pro-epidermal growth factor proteolytic cleavage product def: "A pro-epidermal growth factor that has been processed by proteolytic cleavage." [] synonym: "EGF/ClvPrd" EXACT [] is_a: PR:000006928 ! pro-epidermal growth factor is_a: PR:000018264 ! proteolytic cleavage product intersection_of: PR:000006928 ! pro-epidermal growth factor intersection_of: output_of GO:0016485 relationship: output_of GO:0016485 [Term] id: PR:000019798 name: erythropoietin proteolytic cleavage product def: "An erythropoietin that has been processed by proteolytic cleavage." [] synonym: "EPO/ClvPrd" EXACT [] is_a: PR:000007141 ! erythropoietin is_a: PR:000018264 ! proteolytic cleavage product intersection_of: PR:000007141 ! erythropoietin intersection_of: output_of GO:0016485 relationship: output_of GO:0016485 [Term] id: PR:000019919 name: fibronectin proteolytic cleavage product def: "A fibronectin that has been processed by proteolytic cleavage." [] synonym: "FN1/ClvPrd" EXACT [] is_a: PR:000007581 ! fibronectin is_a: PR:000018264 ! proteolytic cleavage product intersection_of: PR:000007581 ! fibronectin intersection_of: output_of GO:0016485 relationship: output_of GO:0016485 [Term] id: PR:000019959 name: galanin proteolytic cleavage product def: "A galanin that has been processed by proteolytic cleavage." [] synonym: "GAL/ClvPrd" EXACT [] is_a: PR:000007806 ! galanin is_a: PR:000018264 ! proteolytic cleavage product intersection_of: PR:000007806 ! galanin intersection_of: output_of GO:0016485 relationship: output_of GO:0016485 [Term] id: PR:000019973 name: gastrin proteolytic cleavage product def: "A gastrin that has been processed by proteolytic cleavage." [] synonym: "GAST/ClvPrd" EXACT [] is_a: PR:000007856 ! gastrin is_a: PR:000018264 ! proteolytic cleavage product intersection_of: PR:000007856 ! gastrin intersection_of: output_of GO:0016485 relationship: output_of GO:0016485 [Term] id: PR:000019995 name: growth hormone receptor proteolytic cleavage product def: "A growth hormone receptor that has been processed by proteolytic cleavage." [] synonym: "GHR/ClvPrd" EXACT [] is_a: PR:000007970 ! growth hormone receptor is_a: PR:000018264 ! proteolytic cleavage product intersection_of: PR:000007970 ! growth hormone receptor intersection_of: output_of GO:0016485 relationship: output_of GO:0016485 [Term] id: PR:000019996 name: somatoliberin proteolytic cleavage product def: "A somatoliberin that has been processed by proteolytic cleavage." [] synonym: "GHRH/ClvPrd" EXACT [] is_a: PR:000007971 ! somatoliberin is_a: PR:000018264 ! proteolytic cleavage product intersection_of: PR:000007971 ! somatoliberin intersection_of: output_of GO:0016485 relationship: output_of GO:0016485 [Term] id: PR:000019999 name: appetite-regulating hormone proteolytic cleavage product def: "An appetite-regulating hormone that has been processed by proteolytic cleavage." [] synonym: "GHRL/ClvPrd" EXACT [] is_a: PR:000007973 ! appetite-regulating hormone is_a: PR:000018264 ! proteolytic cleavage product intersection_of: PR:000007973 ! appetite-regulating hormone intersection_of: output_of GO:0016485 relationship: output_of GO:0016485 [Term] id: PR:000020124 name: hypocretin neuropeptide precursor proteolytic cleavage product def: "A hypocretin neuropeptide precursor that has been processed by proteolytic cleavage." [] synonym: "HCRT/ClvPrd" EXACT [] is_a: PR:000008476 ! hypocretin neuropeptide precursor is_a: PR:000018264 ! proteolytic cleavage product intersection_of: PR:000008476 ! hypocretin neuropeptide precursor intersection_of: output_of GO:0016485 relationship: output_of GO:0016485 [Term] id: PR:000020135 name: hepatocyte growth factor proteolytic cleavage product def: "A hepatocyte growth factor that has been processed by proteolytic cleavage." [] synonym: "HGF/ClvPrd" EXACT [] is_a: PR:000008534 ! hepatocyte growth factor is_a: PR:000018264 ! proteolytic cleavage product intersection_of: PR:000008534 ! hepatocyte growth factor intersection_of: output_of GO:0016485 relationship: output_of GO:0016485 [Term] id: PR:000020180 name: haptoglobin proteolytic cleavage product def: "A haptoglobin that has been processed by proteolytic cleavage." [] synonym: "HP/ClvPrd" EXACT [] is_a: PR:000008725 ! haptoglobin is_a: PR:000018264 ! proteolytic cleavage product intersection_of: PR:000008725 ! haptoglobin intersection_of: output_of GO:0016485 relationship: output_of GO:0016485 [Term] id: PR:000020226 name: islet amyloid polypeptide proteolytic cleavage product def: "An islet amyloid polypeptide that has been processed by proteolytic cleavage." [] synonym: "IAPP/ClvPrd" EXACT [] is_a: PR:000008875 ! islet amyloid polypeptide is_a: PR:000018264 ! proteolytic cleavage product intersection_of: PR:000008875 ! islet amyloid polypeptide intersection_of: output_of GO:0016485 relationship: output_of GO:0016485 [Term] id: PR:000020267 name: insulin-like growth factor II proteolytic cleavage product def: "An insulin-like growth factor II that has been processed by proteolytic cleavage." [] synonym: "IGF2/ClvPrd" EXACT [] is_a: PR:000008942 ! insulin-like growth factor II is_a: PR:000018264 ! proteolytic cleavage product intersection_of: PR:000008942 ! insulin-like growth factor II intersection_of: output_of GO:0016485 relationship: output_of GO:0016485 [Term] id: PR:000020320 name: insulin receptor proteolytic cleavage product def: "An insulin receptor that has been processed by proteolytic cleavage." [] synonym: "INSR/ClvPrd" EXACT [] is_a: PR:000009064 ! insulin receptor is_a: PR:000018264 ! proteolytic cleavage product intersection_of: PR:000009064 ! insulin receptor intersection_of: output_of GO:0016485 relationship: output_of GO:0016485 [Term] id: PR:000020357 name: insulin-like growth factor I proteolytic cleavage product def: "An insulin-like growth factor I that has been processed by proteolytic cleavage." [] synonym: "IGF1/ClvPrd" EXACT [] is_a: PR:000009182 ! insulin-like growth factor I is_a: PR:000018264 ! proteolytic cleavage product intersection_of: PR:000009182 ! insulin-like growth factor I intersection_of: output_of GO:0016485 relationship: output_of GO:0016485 [Term] id: PR:000020497 name: lactotransferrin proteolytic cleavage product def: "A lactotransferrin that has been processed by proteolytic cleavage." [] synonym: "LTF/ClvPrd" EXACT [] is_a: PR:000009978 ! lactotransferrin is_a: PR:000018264 ! proteolytic cleavage product intersection_of: PR:000009978 ! lactotransferrin intersection_of: output_of GO:0016485 relationship: output_of GO:0016485 [Term] id: PR:000020722 name: NEDD8 protein proteolytic cleavage product def: "A NEDD8 protein that has been processed by proteolytic cleavage." [] synonym: "NEDD8/ClvPrd" EXACT [] is_a: PR:000011116 ! NEDD8 protein is_a: PR:000018264 ! proteolytic cleavage product intersection_of: PR:000011116 ! NEDD8 protein intersection_of: output_of GO:0016485 relationship: output_of GO:0016485 [Term] id: PR:000020737 name: beta-nerve growth factor proteolytic cleavage product def: "A beta-nerve growth factor that has been processed by proteolytic cleavage." [] synonym: "NGF/ClvPrd" EXACT [] is_a: PR:000011194 ! beta-nerve growth factor is_a: PR:000018264 ! proteolytic cleavage product intersection_of: PR:000011194 ! beta-nerve growth factor intersection_of: output_of GO:0016485 relationship: output_of GO:0016485 [Term] id: PR:000020775 name: atrial natriuretic factor proteolytic cleavage product def: "An atrial natriuretic factor that has been processed by proteolytic cleavage." [] synonym: "NPPA/ClvPrd" EXACT [] is_a: PR:000011374 ! atrial natriuretic factor is_a: PR:000018264 ! proteolytic cleavage product intersection_of: PR:000011374 ! atrial natriuretic factor intersection_of: output_of GO:0016485 relationship: output_of GO:0016485 [Term] id: PR:000020789 name: neuropeptide Y proteolytic cleavage product def: "A neuropeptide Y that has been processed by proteolytic cleavage." [] synonym: "NPY/ClvPrd" EXACT [] is_a: PR:000011387 ! neuropeptide Y is_a: PR:000018264 ! proteolytic cleavage product intersection_of: PR:000011387 ! neuropeptide Y intersection_of: output_of GO:0016485 relationship: output_of GO:0016485 [Term] id: PR:000020795 name: neurotrophin-3 proteolytic cleavage product def: "A neurotrophin-3 that has been processed by proteolytic cleavage." [] synonym: "NTF3/ClvPrd" EXACT [] is_a: PR:000011459 ! neurotrophin-3 is_a: PR:000018264 ! proteolytic cleavage product intersection_of: PR:000011459 ! neurotrophin-3 intersection_of: output_of GO:0016485 relationship: output_of GO:0016485 [Term] id: PR:000020841 name: oncostatin-M proteolytic cleavage product def: "An oncostatin-M that has been processed by proteolytic cleavage." [] synonym: "OSM/ClvPrd" EXACT [] is_a: PR:000012059 ! oncostatin-M is_a: PR:000018264 ! proteolytic cleavage product intersection_of: PR:000012059 ! oncostatin-M intersection_of: output_of GO:0016485 relationship: output_of GO:0016485 [Term] id: PR:000020966 name: polymeric immunoglobulin receptor proteolytic cleavage product def: "A polymeric immunoglobulin receptor that has been processed by proteolytic cleavage." [] synonym: "PIGR/ClvPrd" EXACT [] is_a: PR:000012705 ! polymeric immunoglobulin receptor is_a: PR:000018264 ! proteolytic cleavage product intersection_of: PR:000012705 ! polymeric immunoglobulin receptor intersection_of: output_of GO:0016485 relationship: output_of GO:0016485 [Term] id: PR:000021003 name: urokinase-type plasminogen activator proteolytic cleavage product def: "A urokinase-type plasminogen activator that has been processed by proteolytic cleavage." [] synonym: "PLAU/ClvPrd" EXACT [] is_a: PR:000012826 ! urokinase-type plasminogen activator is_a: PR:000018264 ! proteolytic cleavage product intersection_of: PR:000012826 ! urokinase-type plasminogen activator intersection_of: output_of GO:0016485 relationship: output_of GO:0016485 [Term] id: PR:000021066 name: pancreatic prohormone proteolytic cleavage product def: "A pancreatic prohormone that has been processed by proteolytic cleavage." [] synonym: "PPY/ClvPrd" EXACT [] is_a: PR:000013164 ! pancreatic prohormone is_a: PR:000018264 ! proteolytic cleavage product intersection_of: PR:000013164 ! pancreatic prohormone intersection_of: output_of GO:0016485 relationship: output_of GO:0016485 [Term] id: PR:000021170 name: parathyroid hormone proteolytic cleavage product def: "A parathyroid hormone that has been processed by proteolytic cleavage." [] synonym: "PTH/ClvPrd" EXACT [] is_a: PR:000013429 ! parathyroid hormone is_a: PR:000018264 ! proteolytic cleavage product intersection_of: PR:000013429 ! parathyroid hormone intersection_of: output_of GO:0016485 relationship: output_of GO:0016485 [Term] id: PR:000021195 name: peptide YY proteolytic cleavage product def: "A peptide YY that has been processed by proteolytic cleavage." [] synonym: "PYY/ClvPrd" EXACT [] is_a: PR:000013526 ! peptide YY is_a: PR:000018264 ! proteolytic cleavage product intersection_of: PR:000013526 ! peptide YY intersection_of: output_of GO:0016485 relationship: output_of GO:0016485 [Term] id: PR:000021385 name: secretin proteolytic cleavage product def: "A secretin that has been processed by proteolytic cleavage." [] synonym: "SCT/ClvPrd" EXACT [] is_a: PR:000014543 ! secretin is_a: PR:000018264 ! proteolytic cleavage product intersection_of: PR:000014543 ! secretin intersection_of: output_of GO:0016485 relationship: output_of GO:0016485 [Term] id: PR:000021742 name: thyrotropin subunit beta proteolytic cleavage product def: "A thyrotropin subunit beta that has been processed by proteolytic cleavage." [] synonym: "TSHB/ClvPrd" EXACT [] is_a: PR:000016724 ! thyrotropin subunit beta is_a: PR:000018264 ! proteolytic cleavage product intersection_of: PR:000016724 ! thyrotropin subunit beta intersection_of: output_of GO:0016485 relationship: output_of GO:0016485 [Term] id: PR:000021998 name: neurotrophin def: "A protein that is a neurotrophic polypeptide factor that regulates neuronal differentiation and is essential for neuronal survival, neurite growth and plasticity. It contains a signal peptide, a propeptide, and a C-terminal Nerve growth factor family (Pfam:PF00243) domain." [] is_a: PR:000000001 ! protein [Term] id: PR:000021999 name: death receptor def: "A protein that contains multiple TNFR/NGFR cysteine-rich region (Pfam:PF00020) within the extracellular ligand-binding domain, a type I (single pass) transmembrane domain, and a cytoplasmic Death domain (Pfam:PF00531) required for intracellular signaling." [] is_a: PR:000000001 ! protein [Term] id: PR:000022358 name: adenylate cyclase def: "A protein that is a translation product of the Escherichia coli K-12 cyaA gene or a 1:1 ortholog thereof." [] synonym: "adenylyl cyclase" EXACT [] synonym: "ATP pyrophosphate-lyase" EXACT [] synonym: "cya" RELATED [] synonym: "cyaA" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000024025 name: methyl-accepting chemotaxis protein IV def: "A protein that is a translation product of the Escherichia coli K-12 tap gene or a 1:1 ortholog thereof." [] synonym: "dipeptide chemoreceptor protein" EXACT [] synonym: "MCP-IV" EXACT [] synonym: "tap" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000024067 name: homoserine kinase def: "A protein that is a translation product of the Escherichia coli K-12 thrB gene or a 1:1 ortholog thereof." [] synonym: "HK" EXACT [] synonym: "HSK" EXACT [] synonym: "thrB" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000024990 name: type II interferon def: "A protein that binds to a specific cell surface receptor complex known as the IFN-gamma receptor (IFNGR), a complex of two IFNGR1 and two IFNGR2 chains." [] synonym: "IFN type II" EXACT [] synonym: "interferon gamma" RELATED [] synonym: "interferon type II" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000025350 name: HSPC protein def: "An Hsp70 family chaperone that contains an ATPase and HSP90 domains." [] synonym: "HSP90" EXACT [] is_a: PR:000003425 ! Hsp70 family chaperone [Term] id: PR:000025433 name: nodal protein proteolytic cleavage product def: "A nodal protein that has been processed by proteolytic cleavage." [] synonym: "NODAL/ClvPrd" EXACT [] is_a: PR:000000105 ! nodal protein is_a: PR:000018264 ! proteolytic cleavage product intersection_of: PR:000000105 ! nodal protein intersection_of: output_of GO:0016485 relationship: output_of GO:0016485 [Term] id: PR:000025845 name: ephrin receptor def: "A protein that consists of an Ephrin receptor ligand binding domain (Pfam:PF01404), two copies of the Fibronectin type III domain (Pfam:PF00041), and a copy of either type of SAM domain (Sterile alpha motif) (Pfam:PF00536 or Pfam:PF07647)." [] is_a: PR:000000001 ! protein [Term] id: PR:000025848 name: type I interferon def: "A protein that consists solely of an Interferon alpha/beta domain (Pfam:PF00143) and which binds to a specific cell surface receptor complex known as the IFN-alpha receptor (IFNAR), a heterodimer of IFNAR1 and IFNAR2 chains." [] synonym: "IFN type I" EXACT [] synonym: "interferon type I" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000028205 name: type III interferon def: "A class 2 cytokine, IL-10 type that binds to a specific cell surface receptor complex known as the IFN type III receptor, a heterodimer consisting of IFNLR1 and IL-10R2." [] synonym: "IFN type III" EXACT [] synonym: "interferon lambda" RELATED [] synonym: "interferon type III" EXACT [] is_a: PR:000001335 ! class 2 cytokine, IL-10 type [Term] id: PR:000028269 name: thyroid stimulating hormone def: "A protein-containing complex that is a heterodimer of an alpha subunit (CGA) common to several glycoprotein hormones and a beta subunit (TSHB) unique to thyroid stimulating hormone." [] synonym: "thyrotropin" EXACT [] synonym: "TSH" EXACT [] is_a: GO:0032991 relationship: has_component PR:000005388 {cardinality="1"} ! glycoprotein hormones alpha chain relationship: has_component PR:000016724 {cardinality="1"} ! thyrotropin subunit beta [Term] id: PR:000029189 name: AKT kinase def: "A protein that has a core domain composition consisting of a PH domain (Pfam:PF00169), Protein kinase domain (Pfam:PF00069) and a Protein kinase C terminal domain (Pfam:PF00433). Mammals have three genes encoding AKT1, AKT2 and AKT3. The second messenger phosphatidylinositol-3,4,5-trisphosphate [PIP(3)], product of phosphatidylinositol 3-kinase, acts largely through its role as a kinase activator. Binding of the pleckstrin domain to PIP(3) results in its targeting to the plasma membrane. Full activity is gained only after phosphorylation at two sites." [] synonym: "AKT" EXACT [] synonym: "PKB" BROAD [] synonym: "serine-threonine kinase Akt" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000029394 name: antiviral innate immune response receptor RIG-I def: "A protein that is a translation product of the human RIGI gene or a 1:1 ortholog thereof." [] synonym: "ATP-dependent RNA helicase DDX58" EXACT [] synonym: "DDX58" RELATED [] synonym: "DEAD box protein 58" EXACT [] synonym: "probable ATP-dependent RNA helicase DDX58" EXACT [] synonym: "retinoic acid-inducible gene 1 protein" EXACT [] synonym: "retinoic acid-inducible gene I protein" EXACT [] synonym: "RIG-1" EXACT [] synonym: "RIG-I" EXACT [] synonym: "RIG-I-like receptor 1" EXACT [] synonym: "RIGI" EXACT [] synonym: "RLR-1" EXACT [] synonym: "RNA sensor RIG-I" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000029968 name: somatotropin hormone family member def: "A protein that is a standalone version of the Hormone_1 domain (Pfam:PF00103). In the immature form, the domain is preceded by a signal peptide." [] synonym: "fam:GH1" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000030035 name: G-protein coupled receptor def: "A protein that has G protein-coupled receptor (GPCR) activity. Each GPCR consists of a single polypeptide with an extracellular N-terminus, an intracellular C-terminus and seven hydrophobic transmembrane domains (TM1-TM7) linked by three extracellular loops (ECL1-ECL3) and three intracellular loops (ICL1-ICL3). GPCRs function as part of a heterotrimeric complex to transmit an extracellular signal across the membrane by activating an associated G-protein via the exchange of GDP for GTP on the alpha subunit." [] synonym: "7TM receptor" BROAD [] synonym: "fam:GPCR" EXACT [] synonym: "seven-transmembrane receptor" BROAD [] is_a: PR:000000001 ! protein intersection_of: PR:000000001 ! protein intersection_of: capable_of GO:0004930 relationship: capable_of GO:0004930 [Term] id: PR:000030443 name: polyubiquitin-B def: "A tandem-copy polyubiquitin that is a translation product of the human UBB gene or a 1:1 ortholog thereof." [] synonym: "UBB" EXACT [] is_a: PR:000036929 ! tandem-copy polyubiquitin [Term] id: PR:000035716 name: ubiquitin (RPS27A) def: "A ubiquitin-40S ribosomal protein S27a that has been processed by proteolytic cleavage. This form is the N-terminal region consisting of the Ubiquitin (Pfam:PF00240) domain. Example: UniProtKB:P62979, 1-76." [] synonym: "RPS27A/Clv:ubiq" EXACT [] is_a: PR:000014271 ! ubiquitin-40S ribosomal protein S27a is_a: PR:000035728 ! ubiquitin relationship: output_of GO:0016485 [Term] id: PR:000035720 name: ubiquitin (UBC) def: "A polyubiquitin-C that has been processed by proteolytic cleavage to produce a protein consisting of a Ubiquitin (Pfam:PF00240) domain. There are nine copies of ubiquitin in polyubiquitin C. Example: UniProtKB:P0CG48, (1-76) or (77-152) or (153-228) or (229-304) or (305-380) or (381-456) or (457-532) or (533-608) or (609-684)." [] synonym: "UBC/Clv:ubiq" EXACT [] is_a: PR:000016963 ! polyubiquitin-C is_a: PR:000035728 ! ubiquitin relationship: output_of GO:0016485 [Term] id: PR:000035722 name: ubiquitin (UBA52) def: "A ubiquitin-60S ribosomal protein L40 that has been processed by proteolytic cleavage. This form is the N-terminal region consisting of the Ubiquitin (Pfam:PF00240) domain. Example: UniProtKB:P62987, 1-76." [] synonym: "UBA52/Clv:ubiq" EXACT [] is_a: PR:000016954 ! ubiquitin-60S ribosomal protein L40 is_a: PR:000035728 ! ubiquitin relationship: output_of GO:0016485 [Term] id: PR:000035726 name: ubiquitin (UBB) def: "A polyubiquitin-B that has been processed by proteolytic cleavage to produce a protein consisting of a Ubiquitin (Pfam:PF00240) domain. There are three copies of ubiquitin in polyubiquitin B. Example: UniProtKB:P0CG47, (1-76) or (77-152) or (153-228)." [] synonym: "UBB/Clv:ubiq" EXACT [] is_a: PR:000030443 ! polyubiquitin-B is_a: PR:000035728 ! ubiquitin relationship: output_of GO:0016485 [Term] id: PR:000035728 name: ubiquitin def: "A proteolytic cleavage product that gives rise to a protein that corresponds to the stand-alone version of the Ubiquitin (Pfam:PF00240) domain. Example: UniProtKB:P0CG48, 1-76." [] synonym: "Ubiq" EXACT [] is_a: PR:000018264 ! proteolytic cleavage product union_of: PR:000035716 ! ubiquitin (RPS27A) union_of: PR:000035720 ! ubiquitin (UBC) union_of: PR:000035722 ! ubiquitin (UBA52) union_of: PR:000035726 ! ubiquitin (UBB) [Term] id: PR:000036194 name: eukaryotic protein def: "A protein that is encoded in the genome of some Eukaryota." [] synonym: "Eukaryota protein" EXACT [] is_a: PR:000000001 ! protein intersection_of: PR:000000001 ! protein intersection_of: only_in_taxon NCBITaxon:2759 relationship: only_in_taxon NCBITaxon:2759 [Term] id: PR:000036929 name: tandem-copy polyubiquitin def: "A protein that contains multiple tandem copies of the Ubiquitin (Pfam:PF00240) domain within a single amino acid chain." [] synonym: "fam:tandemUb" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000037070 name: phosphoprotein def: "A protein that includes at least one phosphorylated residue." [] synonym: "phosphorylated protein" EXACT [] synonym: "Prot/PhosRes+" EXACT [] is_a: PR:000000001 ! protein intersection_of: PR:000000001 ! protein intersection_of: has_part MOD:00696 relationship: has_part MOD:00696 [Term] id: PR:000044630 name: corticotropin-releasing factor receptor def: "A secretin-like G-protein coupled receptor that is a translation product of the human CRHR1 or CRHR2 genes, 1:1 orthologs thereof, or a semi-ortholog thereof." [] is_a: PR:000001095 ! secretin-like G-protein coupled receptor [Term] id: PR:000044631 name: adrenoceptor protein def: "A rhodopsin-like G-protein coupled receptor that is a translation product of the human ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, or ADRB3 genes, 1:1 orthologs thereof, or a semi-ortholog thereof." [] is_a: PR:000001094 ! rhodopsin-like G-protein coupled receptor [Term] id: PR:000044637 name: calcitonin receptor protein def: "A rhodopsin-like G-protein coupled receptor that is a translation product of the human CALCR or CALCRL genes, 1:1 orthologs thereof, or a semi-ortholog thereof." [] is_a: PR:000001094 ! rhodopsin-like G-protein coupled receptor [Term] id: PR:000044643 name: complement peptide receptor def: "A rhodopsin-like G-protein coupled receptor that is a translation product of the human C3AR1, C5AR1, or C5AR2 genes, 1:1 orthologs thereof, or a semi-ortholog thereof." [] is_a: PR:000001094 ! rhodopsin-like G-protein coupled receptor [Term] id: PR:000044813 name: glycoprotein hormone beta chain def: "A protein that has a core domain composition consisting of a signal peptide followed by a single copy of the Cys_knot (Pfam:PF00007) domain. The Cysteine knot is a protein structural motif containing three disulfide bridges." [] is_a: PR:000000001 ! protein [Term] id: PR:000045358 name: insulin family protein def: "A protein that is a translation product of a gene that encodes a standalone Insulin (Pfam:PF00049) domain preceded by a signal peptide." [] synonym: "fam:INS" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000049989 name: glucagon-like receptor def: "A secretin-like G-protein coupled receptor that is a translation product of the human GHRHR, GIPR, GLP1R, GLP2R, GCGR, or SCTR genes, 1:1 orthologs thereof, or a semi-ortholog thereof." [] synonym: "glucagon receptor" BROAD [] is_a: PR:000001095 ! secretin-like G-protein coupled receptor [Term] id: PR:000049994 name: histamine receptor def: "A rhodopsin-like G-protein coupled receptor that is a translation product of the human HRH1 to HRH4 genes, 1:1 orthologs thereof, or a semi-ortholog thereof." [] is_a: PR:000001094 ! rhodopsin-like G-protein coupled receptor [Term] id: PR:000049997 name: leukotriene receptor def: "A rhodopsin-like G-protein coupled receptor that is a translation product of the human LTB4R, LTB4R2, CYSLTR1, CYSLTR2, or OXER1 genes, 1:1 orthologs thereof, or a semi-ortholog thereof." [] is_a: PR:000001094 ! rhodopsin-like G-protein coupled receptor [Term] id: PR:000050025 name: angiotensinogenase def: "A protein that is a translation product of the mouse Ren1 or Ren2 genes, 1:1 orthologs thereof, or a semi-ortholog thereof." [] synonym: "fam:angiotensinogenase" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000050029 name: thyrotropin-releasing hormone receptor def: "A rhodopsin-like G-protein coupled receptor that has thyrotropin-releasing hormone receptor activity." [] is_a: PR:000001094 ! rhodopsin-like G-protein coupled receptor intersection_of: PR:000001094 ! rhodopsin-like G-protein coupled receptor intersection_of: capable_of GO:0004997 relationship: capable_of GO:0004997 [Term] id: PR:000050043 name: lymphotoxin def: "A tumor necrosis factor, TNF-like that is a translation product of the human LTA or LTB genes, or 1:1 orthologs thereof." [] synonym: "fam:LT" EXACT [] is_a: PR:000000033 ! tumor necrosis factor, TNF-like [Term] id: PR:000050567 name: protein-containing material entity def: "A material entity that minimally consists of a protein." [] synonym: "protein" NARROW [] synonym: "protein aggregate" NARROW [] synonym: "protein complex" NARROW [] synonym: "protein-containing complex" NARROW [] is_a: BFO:0000040 intersection_of: BFO:0000040 intersection_of: has_part PR:000000001 ! protein relationship: has_part PR:000000001 ! protein [Term] id: PR:000060228 name: monoubiquitin def: "A ubiquitin that is a monomer." [] synonym: "monoUbiq" EXACT [] intersection_of: PR:000035728 ! ubiquitin intersection_of: has_constituent_monomer PR:000035728 {cardinality="1"} ! ubiquitin relationship: has_constituent_monomer PR:000035728 {cardinality="1"} ! ubiquitin [Typedef] id: RO:0002330 xref: RO:0002330 [Typedef] id: capable_of name: capable_of xref: RO:0002215 [Typedef] id: has_component name: has_component xref: RO:0002180 [Typedef] id: has_constituent_monomer name: has_constituent_monomer def: "A relation that holds between a polymer and its constituent monomers. P has_constituent_monomer c if and only if P has_component multiple instances of c and each instance of c is covalently attached to another instance of c." [] xref: has_constituent_monomer is_a: has_component ! has_component [Typedef] id: has_gene_template name: has_gene_template def: "See document https://docs.google.com/document/d/15iVMtMyYbQSlvUDgn2XUaDzpwkB0USZI for full definition." [] xref: has_gene_template is_a: RO:0002330 [Typedef] id: has_part name: has_part xref: BFO:0000051 is_transitive: true [Typedef] id: only_in_taxon name: only_in_taxon def: "U only_in_taxon T: U is a feature found in only in organisms of species of taxon T. The feature cannot be found in an organism of any species outside of (not subsumed by) that taxon. Down-propagates in U hierarchy, up-propagates in T hierarchy (species taxonomy). Implies applicable_to_taxon." [] synonym: "never_outside_taxon" EXACT [] synonym: "specific_to" EXACT [] synonym: "specific_to_taxon" EXACT [] xref: RO:0002160 [Typedef] id: output_of name: output_of xref: RO:0002353